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The efficacy of activated protein C in murine endotoxemia is dependent on integrin CD11b.

Cao C, Gao Y, Li Y, Antalis TM, Castellino FJ, Zhang L.

J Clin Invest. 2010 Jun;120(6):1971-80. doi: 10.1172/JCI40380. Epub 2010 May 10.


Endotoxemia and sepsis mortality reduction by non-anticoagulant activated protein C.

Kerschen EJ, Fernandez JA, Cooley BC, Yang XV, Sood R, Mosnier LO, Castellino FJ, Mackman N, Griffin JH, Weiler H.

J Exp Med. 2007 Oct 1;204(10):2439-48. Epub 2007 Sep 24.


Activated protein C targets CD8+ dendritic cells to reduce the mortality of endotoxemia in mice.

Kerschen E, Hernandez I, Zogg M, Jia S, Hessner MJ, Fernandez JA, Griffin JH, Huettner CS, Castellino FJ, Weiler H.

J Clin Invest. 2010 Sep;120(9):3167-78. doi: 10.1172/JCI42629. Epub 2010 Aug 16.


Protection of vascular barrier integrity by activated protein C in murine models depends on protease-activated receptor-1.

Schuepbach RA, Feistritzer C, Fernández JA, Griffin JH, Riewald M.

Thromb Haemost. 2009 Apr;101(4):724-33.


Crosstalk between inflammation and coagulation: the lessons of sepsis.

van der Poll T, Levi M.

Curr Vasc Pharmacol. 2012 Sep;10(5):632-8. Review.


Endogenous protein C has a protective role during Gram-negative pneumosepsis (melioidosis).

Kager LM, Wiersinga WJ, Roelofs JJ, Meijers JC, Zeerleder SS, Esmon CT, van't Veer C, van der Poll T.

J Thromb Haemost. 2013 Feb;11(2):282-92. doi: 10.1111/jth.12094.


Activated protein C mediates novel lung endothelial barrier enhancement: role of sphingosine 1-phosphate receptor transactivation.

Finigan JH, Dudek SM, Singleton PA, Chiang ET, Jacobson JR, Camp SM, Ye SQ, Garcia JG.

J Biol Chem. 2005 Apr 29;280(17):17286-93. Epub 2005 Feb 14.


Activated protein C signals through the thrombin receptor PAR1 in endothelial cells.

Riewald M, Petrovan RJ, Donner A, Ruf W.

J Endotoxin Res. 2003;9(5):317-21.


Receptors of the protein C activation and activated protein C signaling pathways are colocalized in lipid rafts of endothelial cells.

Bae JS, Yang L, Rezaie AR.

Proc Natl Acad Sci U S A. 2007 Feb 20;104(8):2867-72. Epub 2007 Feb 13.


Endothelial protein C receptor-assisted transport of activated protein C across the mouse blood-brain barrier.

Deane R, LaRue B, Sagare AP, Castellino FJ, Zhong Z, Zlokovic BV.

J Cereb Blood Flow Metab. 2009 Jan;29(1):25-33. doi: 10.1038/jcbfm.2008.117. Epub 2008 Oct 8.


Endogenous EPCR/aPC-PAR1 signaling prevents inflammation-induced vascular leakage and lethality.

Niessen F, Furlan-Freguia C, Fernández JA, Mosnier LO, Castellino FJ, Weiler H, Rosen H, Griffin JH, Ruf W.

Blood. 2009 Mar 19;113(12):2859-66. doi: 10.1182/blood-2008-12-192385. Epub 2009 Jan 13. Retraction in: Blood. 2011 Jun 30;117(26):7188.


Activated protein C β-glycoform promotes enhanced noncanonical PAR1 proteolysis and superior resistance to ischemic injury.

Gleeson EM, Dichiara MG, Salicio A, Quinn LM, Drakeford C, Russell SE, Walsh PT, Orbe J, Hermida J, Smith OP, O'Donnell JS, Montes R, Preston RJ.

Blood. 2015 Aug 13;126(7):915-9. doi: 10.1182/blood-2015-03-632877. Epub 2015 Jun 17.


Selective inhibitory effects of the anticoagulant activated protein C on the responses of human mononuclear phagocytes to LPS, IFN-gamma, or phorbol ester.

Grey ST, Tsuchida A, Hau H, Orthner CL, Salem HH, Hancock WW.

J Immunol. 1994 Oct 15;153(8):3664-72.


Age-dependent vulnerability to endotoxemia is associated with reduction of anticoagulant factors activated protein C and thrombomodulin.

Starr ME, Ueda J, Takahashi H, Weiler H, Esmon CT, Evers BM, Saito H.

Blood. 2010 Jun 10;115(23):4886-93. doi: 10.1182/blood-2009-10-246678. Epub 2010 Mar 26.


New players in the sepsis-protective activated protein C pathway.

Ruf W.

J Clin Invest. 2010 Sep;120(9):3084-7. doi: 10.1172/JCI44266. Epub 2010 Aug 16.


The endothelial protein C receptor and activated protein C play a limited role in host defense during experimental tuberculosis.

Kager LM, Roelofs JJ, de Vos AF, Wieland CW, Schouten M, Meijers JC, Isermann B, Van't Veer C, Esmon CT, van der Poll T.

Thromb Haemost. 2013 Apr;109(4):726-37. doi: 10.1160/TH12-11-0859. Epub 2013 Jan 24.


Sphingosine kinase 1 mediation of expression of the anaphylatoxin receptor C5L2 dampens the inflammatory response to endotoxin.

Bachmaier K, Guzman E, Kawamura T, Gao X, Malik AB.

PLoS One. 2012;7(2):e30742. doi: 10.1371/journal.pone.0030742. Epub 2012 Feb 15.

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