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NMR-based design and evaluation of novel bidentate inhibitors of the protein tyrosine phosphatase YopH.

Leone M, Barile E, Vazquez J, Mei A, Guiney D, Dahl R, Pellecchia M.

Chem Biol Drug Des. 2010 Jul;76(1):10-6. doi: 10.1111/j.1747-0285.2010.00982.x. Epub 2010 Apr 28.


Development of molecular probes for second-site screening and design of protein tyrosine phosphatase inhibitors.

Vazquez J, Tautz L, Ryan JJ, Vuori K, Mustelin T, Pellecchia M.

J Med Chem. 2007 May 3;50(9):2137-43. Epub 2007 Mar 30.


High-resolution structure of the Yersinia pestis protein tyrosine phosphatase YopH in complex with a phosphotyrosyl mimetic-containing hexapeptide.

Phan J, Lee K, Cherry S, Tropea JE, Burke TR Jr, Waugh DS.

Biochemistry. 2003 Nov 18;42(45):13113-21.


A focused library of protein tyrosine phosphatase inhibitors.

Comeau AB, Critton DA, Page R, Seto CT.

J Med Chem. 2010 Sep 23;53(18):6768-72. doi: 10.1021/jm100528p.


High-Throughput Screening (HTS) by NMR Guided Identification of Novel Agents Targeting the Protein Docking Domain of YopH.

Bottini A, Wu B, Barile E, De SK, Leone M, Pellecchia M.

ChemMedChem. 2016 Apr 19;11(8):919-27. doi: 10.1002/cmdc.201500441. Epub 2015 Nov 23.


Inhibition of Yersinia tyrosine phosphatase by furanyl salicylate compounds.

Tautz L, Bruckner S, Sareth S, Alonso A, Bogetz J, Bottini N, Pellecchia M, Mustelin T.

J Biol Chem. 2005 Mar 11;280(10):9400-8. Epub 2004 Dec 22.


Biomolecular Interactions of small-molecule inhibitors affecting the YopH protein tyrosine phosphatase.

Hogan M, Bahta M, Cherry S, Lountos GT, Tropea JE, Zhao BM, Burke TR Jr, Waugh DS, Ulrich RG.

Chem Biol Drug Des. 2013 Mar;81(3):323-33. doi: 10.1111/cbdd.12097.


Synthesis of tripeptides as potent Yersinia protein tyrosine phosphatase inhibitors.

Lee K, Boovanahalli SK, Nam KY, Kang SU, Lee M, Phan J, Wu L, Waugh DS, Zhang ZY, No KT, Lee JJ, Burke TR Jr.

Bioorg Med Chem Lett. 2005 Sep 15;15(18):4037-42.


Derivatives of salicylic acid as inhibitors of YopH in Yersinia pestis.

Huang Z, He Y, Zhang X, Gunawan A, Wu L, Zhang ZY, Wong CF.

Chem Biol Drug Des. 2010 Aug;76(2):85-99. doi: 10.1111/j.1747-0285.2010.00996.x. Epub 2010 Jun 18.


Design and NMR studies of cyclic peptides targeting the N-terminal domain of the protein tyrosine phosphatase YopH.

Leone M, Barile E, Dahl R, Pellecchia M.

Chem Biol Drug Des. 2011 Jan;77(1):12-9. doi: 10.1111/j.1747-0285.2010.01058.x. Epub 2010 Nov 30.


Computational analysis of tyrosine phosphatase inhibitor selectivity for the virulence factors YopH and SptP.

Hu X, Vujanac M, Stebbins CE.

J Mol Graph Model. 2004 Oct;23(2):175-87.


Isothiazolidinone (IZD) as a phosphoryl mimetic in inhibitors of the Yersinia pestis protein tyrosine phosphatase YopH.

Kim SE, Bahta M, Lountos GT, Ulrich RG, Burke TR Jr, Waugh DS.

Acta Crystallogr D Biol Crystallogr. 2011 Jul;67(Pt 7):639-45. doi: 10.1107/S0907444911018610. Epub 2011 Jun 11.


Structure of the type III secretion and substrate-binding domain of Yersinia YopH phosphatase.

Smith CL, Khandelwal P, Keliikuli K, Zuiderweg ER, Saper MA.

Mol Microbiol. 2001 Nov;42(4):967-79.


Inhibitors of the Yersinia protein tyrosine phosphatase through high throughput and virtual screening approaches.

Hu X, Vujanac M, Southall N, Stebbins CE.

Bioorg Med Chem Lett. 2013 Feb 15;23(4):1056-62. doi: 10.1016/j.bmcl.2012.12.018. Epub 2012 Dec 20.


Utilization of nitrophenylphosphates and oxime-based ligation for the development of nanomolar affinity inhibitors of the Yersinia pestis outer protein H (YopH) phosphatase.

Bahta M, Lountos GT, Dyas B, Kim SE, Ulrich RG, Waugh DS, Burke TR Jr.

J Med Chem. 2011 Apr 28;54(8):2933-43. doi: 10.1021/jm200022g. Epub 2011 Mar 28.


¹H, ¹⁵N, and ¹³C backbone resonance assignments for the Yersinia protein tyrosine phosphatase YopH.

Whittier SK, Loria JP.

Biomol NMR Assign. 2014 Oct;8(2):387-9. doi: 10.1007/s12104-013-9524-0. Epub 2013 Sep 12.


A rapid oxime linker-based library approach to identification of bivalent inhibitors of the Yersinia pestis protein-tyrosine phosphatase, YopH.

Liu F, Hakami RM, Dyas B, Bahta M, Lountos GT, Waugh DS, Ulrich RG, Burke TR Jr.

Bioorg Med Chem Lett. 2010 May 1;20(9):2813-6. doi: 10.1016/j.bmcl.2010.03.058. Epub 2010 Mar 15.


Redox process is crucial for inhibitory properties of aurintricarboxylic acid against activity of YopH: virulence factor of Yersinia pestis.

Kuban-Jankowska A, Sahu KK, Niedzialkowski P, Gorska M, Tuszynski JA, Ossowski T, Wozniak M.

Oncotarget. 2015 Jul 30;6(21):18364-73.

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