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Murine lupus susceptibility locus Sle1a requires the expression of two sub-loci to induce inflammatory T cells.

Cuda CM, Zeumer L, Sobel ES, Croker BP, Morel L.

Genes Immun. 2010 Oct;11(7):542-53. doi: 10.1038/gene.2010.23. Epub 2010 May 6.


Murine lupus susceptibility locus Sle1a controls regulatory T cell number and function through multiple mechanisms.

Cuda CM, Wan S, Sobel ES, Croker BP, Morel L.

J Immunol. 2007 Dec 1;179(11):7439-47.


Several genes contribute to the production of autoreactive B and T cells in the murine lupus susceptibility locus Sle1c.

Chen Y, Perry D, Boackle SA, Sobel ES, Molina H, Croker BP, Morel L.

J Immunol. 2005 Jul 15;175(2):1080-9.


Genetic determination of T cell help in loss of tolerance to nuclear antigens.

Chen Y, Cuda C, Morel L.

J Immunol. 2005 Jun 15;174(12):7692-702.


Murine lupus susceptibility locus Sle1c2 mediates CD4+ T cell activation and maps to estrogen-related receptor γ.

Perry DJ, Yin Y, Telarico T, Baker HV, Dozmorov I, Perl A, Morel L.

J Immunol. 2012 Jul 15;189(2):793-803. doi: 10.4049/jimmunol.1200411. Epub 2012 Jun 18.


Expression of the autoimmune Fcgr2b NZW allele fails to be upregulated in germinal center B cells and is associated with increased IgG production.

Rahman ZS, Niu H, Perry D, Wakeland E, Manser T, Morel L.

Genes Immun. 2007 Oct;8(7):604-12. Epub 2007 Aug 23.


Pre-B cell leukemia homeobox 1 is associated with lupus susceptibility in mice and humans.

Cuda CM, Li S, Liang S, Yin Y, Potula HH, Xu Z, Sengupta M, Chen Y, Butfiloski E, Baker H, Chang LJ, Dozmorov I, Sobel ES, Morel L.

J Immunol. 2012 Jan 15;188(2):604-14. doi: 10.4049/jimmunol.1002362. Epub 2011 Dec 16.


Genetic interactions between susceptibility loci reveal epistatic pathogenic networks in murine lupus.

Croker BP, Gilkeson G, Morel L.

Genes Immun. 2003 Dec;4(8):575-85.


A New Zealand Black-derived locus suppresses chronic graft-versus-host disease and autoantibody production through nonlymphoid bone marrow-derived cells.

Xu Z, Vallurupalli A, Fuhrman C, Ostrov D, Morel L.

J Immunol. 2011 Apr 1;186(7):4130-9. doi: 10.4049/jimmunol.1003512. Epub 2011 Feb 18.


Murine lupus susceptibility locus Sle2 activates DNA-reactive B cells through two sub-loci with distinct phenotypes.

Zeumer L, Sang A, Niu H, Morel L.

Genes Immun. 2011 Apr;12(3):199-207. doi: 10.1038/gene.2010.69. Epub 2011 Jan 27.


The major murine systemic lupus erythematosus susceptibility locus Sle1 results in abnormal functions of both B and T cells.

Sobel ES, Satoh M, Chen Y, Wakeland EK, Morel L.

J Immunol. 2002 Sep 1;169(5):2694-700.


Epistatic suppression of systemic lupus erythematosus: fine mapping of Sles1 to less than 1 mb.

Subramanian S, Yim YS, Liu K, Tus K, Zhou XJ, Wakeland EK.

J Immunol. 2005 Jul 15;175(2):1062-72.


IL-10 regulation of lupus in the NZM2410 murine model.

Blenman KR, Duan B, Xu Z, Wan S, Atkinson MA, Flotte TR, Croker BP, Morel L.

Lab Invest. 2006 Nov;86(11):1136-48. Epub 2006 Aug 21.


Identification of a lupus-susceptibility locus leading to impaired clearance of apoptotic debris on New Zealand Black chromosome 13.

Pau E, Loh C, Minty GE, Chang NH, Wither JE.

Genes Immun. 2013 Apr;14(3):154-61. doi: 10.1038/gene.2012.64. Epub 2013 Jan 17.


Genetic dissection of systemic lupus erythematosus pathogenesis: evidence for functional expression of Sle3/5 by non-T cells.

Sobel ES, Morel L, Baert R, Mohan C, Schiffenbauer J, Wakeland EK.

J Immunol. 2002 Oct 1;169(7):4025-32.


The major murine systemic lupus erythematosus susceptibility locus, Sle1, is a cluster of functionally related genes.

Morel L, Blenman KR, Croker BP, Wakeland EK.

Proc Natl Acad Sci U S A. 2001 Feb 13;98(4):1787-92. Epub 2001 Jan 23.

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