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Emphysema mediated by lung overexpression of ADAM10.

Saitoh H, Leopold PL, Harvey BG, O'Connor TP, Worgall S, Hackett NR, Crystal RG.

Clin Transl Sci. 2009 Feb;2(1):50-6. doi: 10.1111/j.1752-8062.2008.00085.x.


The Antiatherogenic Effect of Fish Oil in Male Mice Is Associated with a Diminished Release of Endothelial ADAM17 and ADAM10 Substrates.

Speck N, Brandsch C, Schmidt N, Yazdekhasti N, Hirche F, Lucius R, Rimbach G, Stangl GI, Reiss K.

J Nutr. 2015 Jun;145(6):1218-26. doi: 10.3945/jn.115.211375. Epub 2015 Apr 29.


Inhibiting adenoid cystic carcinoma cells growth and metastasis by blocking the expression of ADAM 10 using RNA interference.

Xu Q, Liu X, Chen W, Zhang Z.

J Transl Med. 2010 Dec 20;8:136. doi: 10.1186/1479-5876-8-136.


Shedding of klotho by ADAMs in the kidney.

van Loon EP, Pulskens WP, van der Hagen EA, Lavrijsen M, Vervloet MG, van Goor H, Bindels RJ, Hoenderop JG.

Am J Physiol Renal Physiol. 2015 Aug 15;309(4):F359-68. doi: 10.1152/ajprenal.00240.2014. Epub 2015 Jul 8.


Activation of peroxisome proliferator-activated receptor α stimulates ADAM10-mediated proteolysis of APP.

Corbett GT, Gonzalez FJ, Pahan K.

Proc Natl Acad Sci U S A. 2015 Jul 7;112(27):8445-50. doi: 10.1073/pnas.1504890112. Epub 2015 Jun 15.


A disintegrin and metalloprotease (ADAM)10 is highly expressed in hepatocellular carcinoma and is associated with tumour progression.

Zhang W, Liu S, Liu K, Wang Y, Ji B, Zhang X, Liu Y.

J Int Med Res. 2014 Jun;42(3):611-8. doi: 10.1177/0300060513505500. Epub 2014 Mar 26.


The retinoic acid receptor agonist Am80 increases hippocampal ADAM10 in aged SAMP8 mice.

Kitaoka K, Shimizu N, Ono K, Chikahisa S, Nakagomi M, Shudo K, Ishimura K, Séi H, Yoshizaki K.

Neuropharmacology. 2013 Sep;72:58-65. doi: 10.1016/j.neuropharm.2013.04.009. Epub 2013 Apr 23.


Effects of neuron-specific ADAM10 modulation in an in vivo model of acute excitotoxic stress.

Clement AB, Hanstein R, Schröder A, Nagel H, Endres K, Fahrenholz F, Behl C.

Neuroscience. 2008 Mar 18;152(2):459-68. doi: 10.1016/j.neuroscience.2007.10.060. Epub 2008 Jan 12.


ADAM10 is the major sheddase responsible for the release of membrane-associated meprin A.

Herzog C, Haun RS, Ludwig A, Shah SV, Kaushal GP.

J Biol Chem. 2014 May 9;289(19):13308-22. doi: 10.1074/jbc.M114.559088. Epub 2014 Mar 24.


Unfolded protein response signaling by transcription factor XBP-1 regulates ADAM10 and is affected in Alzheimer's disease.

Reinhardt S, Schuck F, Grösgen S, Riemenschneider M, Hartmann T, Postina R, Grimm M, Endres K.

FASEB J. 2014 Feb;28(2):978-97. doi: 10.1096/fj.13-234864. Epub 2013 Oct 28.


A Staphylococcus aureus pore-forming toxin subverts the activity of ADAM10 to cause lethal infection in mice.

Inoshima I, Inoshima N, Wilke GA, Powers ME, Frank KM, Wang Y, Bubeck Wardenburg J.

Nat Med. 2011 Sep 18;17(10):1310-4. doi: 10.1038/nm.2451.


Capsaicin-induced inactivation of sensory neurons promotes a more aggressive gene expression phenotype in breast cancer cells.

Erin N, Zhao W, Bylander J, Chase G, Clawson G.

Breast Cancer Res Treat. 2006 Oct;99(3):351-64. Epub 2006 Apr 1.


Leukocytes require ADAM10 but not ADAM17 for their migration and inflammatory recruitment into the alveolar space.

Pruessmeyer J, Hess FM, Alert H, Groth E, Pasqualon T, Schwarz N, Nyamoya S, Kollert J, van der Vorst E, Donners M, Martin C, Uhlig S, Saftig P, Dreymueller D, Ludwig A.

Blood. 2014 Jun 26;123(26):4077-88. doi: 10.1182/blood-2013-09-511543. Epub 2014 May 15.


Effect of a dominant-negative form of ADAM10 in a mouse model of Alzheimer's disease.

Schroeder A, Fahrenholz F, Schmitt U.

J Alzheimers Dis. 2009;16(2):309-14. doi: 10.3233/JAD-2009-0952.


Dysregulated ADAM10-Mediated Processing of APP during a Critical Time Window Leads to Synaptic Deficits in Fragile X Syndrome.

Pasciuto E, Ahmed T, Wahle T, Gardoni F, D'Andrea L, Pacini L, Jacquemont S, Tassone F, Balschun D, Dotti CG, Callaerts-Vegh Z, D'Hooge R, Müller UC, Di Luca M, De Strooper B, Bagni C.

Neuron. 2015 Jul 15;87(2):382-98. doi: 10.1016/j.neuron.2015.06.032. Erratum in: Neuron. 2015 Aug 19;87(4):908.


Increase of disintergin metalloprotease 10 (ADAM10) expression in oral squamous cell carcinoma.

Ko SY, Lin SC, Wong YK, Liu CJ, Chang KW, Liu TY.

Cancer Lett. 2007 Jan 8;245(1-2):33-43. Epub 2005 Nov 23.


Dual functions of cell-autonomous and non-cell-autonomous ADAM10 activity in granulopoiesis.

Yoda M, Kimura T, Tohmonda T, Uchikawa S, Koba T, Takito J, Morioka H, Matsumoto M, Link DC, Chiba K, Okada Y, Toyama Y, Horiuchi K.

Blood. 2011 Dec 22;118(26):6939-42. doi: 10.1182/blood-2011-06-357210. Epub 2011 Oct 31.


Differential gene expression in ADAM10 and mutant ADAM10 transgenic mice.

Prinzen C, Trümbach D, Wurst W, Endres K, Postina R, Fahrenholz F.

BMC Genomics. 2009 Feb 5;10:66. doi: 10.1186/1471-2164-10-66.


T-cell immunoglobulin and mucin domain 2 (TIM-2) is a target of ADAM10-mediated ectodomain shedding.

Dewitz C, Möller-Hackbarth K, Schweigert O, Reiss K, Chalaris A, Scheller J, Rose-John S.

FEBS J. 2014 Jan;281(1):157-74. doi: 10.1111/febs.12583. Epub 2013 Nov 19.


ADAM10 overexpression in human non-small cell lung cancer correlates with cell migration and invasion through the activation of the Notch1 signaling pathway.

Guo J, He L, Yuan P, Wang P, Lu Y, Tong F, Wang Y, Yin Y, Tian J, Sun J.

Oncol Rep. 2012 Nov;28(5):1709-18. doi: 10.3892/or.2012.2003. Epub 2012 Aug 30.


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