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Items: 1 to 20 of 94

1.

Ablation of LKB1 in the heart leads to energy deprivation and impaired cardiac function.

Jessen N, Koh HJ, Folmes CD, Wagg C, Fujii N, Løfgren B, Wolf CM, Berul CI, Hirshman MF, Lopaschuk GD, Goodyear LJ.

Biochim Biophys Acta. 2010 Jul-Aug;1802(7-8):593-600. doi: 10.1016/j.bbadis.2010.04.008. Epub 2010 May 2.

2.

Deficiency of LKB1 in heart prevents ischemia-mediated activation of AMPKalpha2 but not AMPKalpha1.

Sakamoto K, Zarrinpashneh E, Budas GR, Pouleur AC, Dutta A, Prescott AR, Vanoverschelde JL, Ashworth A, Jovanović A, Alessi DR, Bertrand L.

Am J Physiol Endocrinol Metab. 2006 May;290(5):E780-8. Epub 2005 Dec 6.

3.

Cardiac-specific deletion of LKB1 leads to hypertrophy and dysfunction.

Ikeda Y, Sato K, Pimentel DR, Sam F, Shaw RJ, Dyck JR, Walsh K.

J Biol Chem. 2009 Dec 18;284(51):35839-49. doi: 10.1074/jbc.M109.057273.

4.

Differential regulation of eEF2 and p70S6K by AMPKalpha2 in heart.

Demeulder B, Zarrinpashneh E, Ginion A, Viollet B, Hue L, Rider MH, Vanoverschelde JL, Beauloye C, Horman S, Bertrand L.

Biochim Biophys Acta. 2013 Jun;1832(6):780-90. doi: 10.1016/j.bbadis.2013.02.015. Epub 2013 Mar 4.

5.

Myocardial ischemia differentially regulates LKB1 and an alternate 5'-AMP-activated protein kinase kinase.

Altarejos JY, Taniguchi M, Clanachan AS, Lopaschuk GD.

J Biol Chem. 2005 Jan 7;280(1):183-90. Epub 2004 Oct 26.

6.

Sestrin2 promotes LKB1-mediated AMPK activation in the ischemic heart.

Morrison A, Chen L, Wang J, Zhang M, Yang H, Ma Y, Budanov A, Lee JH, Karin M, Li J.

FASEB J. 2015 Feb;29(2):408-17. doi: 10.1096/fj.14-258814. Epub 2014 Nov 3.

7.

Distinct roles of autophagy in the heart during ischemia and reperfusion: roles of AMP-activated protein kinase and Beclin 1 in mediating autophagy.

Matsui Y, Takagi H, Qu X, Abdellatif M, Sakoda H, Asano T, Levine B, Sadoshima J.

Circ Res. 2007 Mar 30;100(6):914-22. Epub 2007 Mar 1.

8.

Dual cardiac contractile effects of the alpha2-AMPK deletion in low-flow ischemia and reperfusion.

Carvajal K, Zarrinpashneh E, Szarszoi O, Joubert F, Athea Y, Mateo P, Gillet B, Vaulont S, Viollet B, Bigard X, Bertrand L, Ventura-Clapier R, Hoerter JA.

Am J Physiol Heart Circ Physiol. 2007 Jun;292(6):H3136-47. Epub 2007 Mar 2.

9.

Cardioprotective actions of Notch1 against myocardial infarction via LKB1-dependent AMPK signaling pathway.

Yang H, Sun W, Quan N, Wang L, Chu D, Cates C, Liu Q, Zheng Y, Li J.

Biochem Pharmacol. 2016 May 15;108:47-57. doi: 10.1016/j.bcp.2016.03.019. Epub 2016 Mar 22.

10.

Glucose metabolism and energy homeostasis in mouse hearts overexpressing dominant negative alpha2 subunit of AMP-activated protein kinase.

Xing Y, Musi N, Fujii N, Zou L, Luptak I, Hirshman MF, Goodyear LJ, Tian R.

J Biol Chem. 2003 Aug 1;278(31):28372-7. Epub 2003 May 23.

11.

LKB1 and the regulation of malonyl-CoA and fatty acid oxidation in muscle.

Thomson DM, Brown JD, Fillmore N, Condon BM, Kim HJ, Barrow JR, Winder WW.

Am J Physiol Endocrinol Metab. 2007 Dec;293(6):E1572-9. Epub 2007 Oct 9.

12.

Role of AMP-activated protein kinase in healthy and diseased hearts.

Dolinsky VW, Dyck JR.

Am J Physiol Heart Circ Physiol. 2006 Dec;291(6):H2557-69. Epub 2006 Jul 14. Review.

13.

Skeletal muscle and heart LKB1 deficiency causes decreased voluntary running and reduced muscle mitochondrial marker enzyme expression in mice.

Thomson DM, Porter BB, Tall JH, Kim HJ, Barrow JR, Winder WW.

Am J Physiol Endocrinol Metab. 2007 Jan;292(1):E196-202. Epub 2006 Aug 22.

14.

Marked phenotypic differences of endurance performance and exercise-induced oxygen consumption between AMPK and LKB1 deficiency in mouse skeletal muscle: changes occurring in the diaphragm.

Miura S, Kai Y, Tadaishi M, Tokutake Y, Sakamoto K, Bruce CR, Febbraio MA, Kita K, Chohnan S, Ezaki O.

Am J Physiol Endocrinol Metab. 2013 Jul 15;305(2):E213-29. doi: 10.1152/ajpendo.00114.2013. Epub 2013 May 21.

15.

Lkb1 regulates quiescence and metabolic homeostasis of haematopoietic stem cells.

Gan B, Hu J, Jiang S, Liu Y, Sahin E, Zhuang L, Fletcher-Sananikone E, Colla S, Wang YA, Chin L, Depinho RA.

Nature. 2010 Dec 2;468(7324):701-4. doi: 10.1038/nature09595.

16.

The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress.

Shaw RJ, Kosmatka M, Bardeesy N, Hurley RL, Witters LA, DePinho RA, Cantley LC.

Proc Natl Acad Sci U S A. 2004 Mar 9;101(10):3329-35. Epub 2004 Feb 25.

17.

Resveratrol prevents the prohypertrophic effects of oxidative stress on LKB1.

Dolinsky VW, Chan AY, Robillard Frayne I, Light PE, Des Rosiers C, Dyck JR.

Circulation. 2009 Mar 31;119(12):1643-52. doi: 10.1161/CIRCULATIONAHA.108.787440. Epub 2009 Mar 16.

18.

Lkb1 regulates cell cycle and energy metabolism in haematopoietic stem cells.

Nakada D, Saunders TL, Morrison SJ.

Nature. 2010 Dec 2;468(7324):653-8. doi: 10.1038/nature09571.

19.

LKB1 deficiency in Tie2-Cre-expressing cells impairs ischemia-induced angiogenesis.

Ohashi K, Ouchi N, Higuchi A, Shaw RJ, Walsh K.

J Biol Chem. 2010 Jul 16;285(29):22291-8. doi: 10.1074/jbc.M110.123794. Epub 2010 May 19.

20.

LKB1 and AMP-activated protein kinase control of mTOR signalling and growth.

Shaw RJ.

Acta Physiol (Oxf). 2009 May;196(1):65-80. doi: 10.1111/j.1748-1716.2009.01972.x. Epub 2009 Feb 19. Review.

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