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Prostate apoptosis response protein 4 sensitizes human colon cancer cells to chemotherapeutic 5-FU through mediation of an NF kappaB and microRNA network.

Wang BD, Kline CL, Pastor DM, Olson TL, Frank B, Luu T, Sharma AK, Robertson G, Weirauch MT, Patierno SR, Stuart JM, Irby RB, Lee NH.

Mol Cancer. 2010 Apr 30;9:98. doi: 10.1186/1476-4598-9-98.


The Akt inhibitor ISC-4 activates prostate apoptosis response protein-4 and reduces colon tumor growth in a nude mouse model.

Sharma AK, Kline CL, Berg A, Amin S, Irby RB.

Clin Cancer Res. 2011 Jul 1;17(13):4474-83. doi: 10.1158/1078-0432.CCR-10-2370. Epub 2011 May 9.


MicroRNA-23a antisense enhances 5-fluorouracil chemosensitivity through APAF-1/caspase-9 apoptotic pathway in colorectal cancer cells.

Shang J, Yang F, Wang Y, Wang Y, Xue G, Mei Q, Wang F, Sun S.

J Cell Biochem. 2014 Apr;115(4):772-84. doi: 10.1002/jcb.24721.


Melatonin synergizes the chemotherapeutic effect of 5-fluorouracil in colon cancer by suppressing PI3K/AKT and NF-κB/iNOS signaling pathways.

Gao Y, Xiao X, Zhang C, Yu W, Guo W, Zhang Z, Li Z, Feng X, Hao J, Zhang K, Xiao B, Chen M, Huang W, Xiong S, Wu X, Deng W.

J Pineal Res. 2017 Mar;62(2). doi: 10.1111/jpi.12380. Epub 2016 Dec 24.


Dysregulation of microRNA-34a expression causes drug-resistance to 5-FU in human colon cancer DLD-1 cells.

Akao Y, Noguchi S, Iio A, Kojima K, Takagi T, Naoe T.

Cancer Lett. 2011 Jan 28;300(2):197-204. doi: 10.1016/j.canlet.2010.10.006. Epub 2010 Nov 9.


Overexpression of Par-4 sensitizes TRAIL-induced apoptosis via inactivation of NF-kappaB and Akt signaling pathways in renal cancer cells.

Lee TJ, Jang JH, Noh HJ, Park EJ, Choi KS, Kwon TK.

J Cell Biochem. 2010 Apr 1;109(5):885-95. doi: 10.1002/jcb.22504.


MicroRNA-143 reduces viability and increases sensitivity to 5-fluorouracil in HCT116 human colorectal cancer cells.

Borralho PM, Kren BT, Castro RE, da Silva IB, Steer CJ, Rodrigues CM.

FEBS J. 2009 Nov;276(22):6689-700. doi: 10.1111/j.1742-4658.2009.07383.x. Epub 2009 Oct 16.


MicroRNA-494 sensitizes colon cancer cells to fluorouracil through regulation of DPYD.

Chai J, Dong W, Xie C, Wang L, Han DL, Wang S, Guo HL, Zhang ZL.

IUBMB Life. 2015 Mar;67(3):191-201. doi: 10.1002/iub.1361. Epub 2015 Apr 15.


LY294002 may overcome 5-FU resistance via down-regulation of activated p-AKT in Epstein-Barr virus-positive gastric cancer cells.

Shin JY, Kim JO, Lee SK, Chae HS, Kang JH.

BMC Cancer. 2010 Aug 13;10:425. doi: 10.1186/1471-2407-10-425.


MicroRNA-520a attenuates proliferation of Raji cells through inhibition of AKT1/NF-κB and PERK/eIF2α signaling pathway.

Wang X, Wang P, Zhu Y, Zhang Z, Zhang J, Wang H.

Oncol Rep. 2016 Sep;36(3):1702-8. doi: 10.3892/or.2016.4975. Epub 2016 Jul 25.


The effect of focal adhesion kinase gene silencing on 5-fluorouracil chemosensitivity involves an Akt/NF-kappaB signaling pathway in colorectal carcinomas.

Chen Y, Wang Z, Chang P, Xiang L, Pan F, Li J, Jiang J, Zou L, Yang L, Bian Z, Liang H.

Int J Cancer. 2010 Jul 1;127(1):195-206. doi: 10.1002/ijc.25025.


MicroRNA-26b suppresses the NF-κB signaling and enhances the chemosensitivity of hepatocellular carcinoma cells by targeting TAK1 and TAB3.

Zhao N, Wang R, Zhou L, Zhu Y, Gong J, Zhuang SM.

Mol Cancer. 2014 Feb 24;13:35. doi: 10.1186/1476-4598-13-35.


MicroRNA-362 induces cell proliferation and apoptosis resistance in gastric cancer by activation of NF-κB signaling.

Xia JT, Chen LZ, Jian WH, Wang KB, Yang YZ, He WL, He YL, Chen D, Li W.

J Transl Med. 2014 Feb 5;12:33. doi: 10.1186/1479-5876-12-33.


DNA-PKcs deficiency sensitizes the human hepatoma HepG2 cells to cisplatin and 5-fluorouracil through suppression of the PI3K/Akt/NF-κB pathway.

Fang Y, Chai Z, Wang D, Kuang T, Wu W, Lou W.

Mol Cell Biochem. 2015 Jan;399(1-2):269-78. doi: 10.1007/s11010-014-2253-6. Epub 2014 Oct 28.


MicroRNA-9 up-regulates E-cadherin through inhibition of NF-κB1-Snail1 pathway in melanoma.

Liu S, Kumar SM, Lu H, Liu A, Yang R, Pushparajan A, Guo W, Xu X.

J Pathol. 2012 Jan;226(1):61-72. doi: 10.1002/path.2964. Epub 2011 Aug 24.


Upregulation of Akt/NF-κB-regulated inflammation and Akt/Bad-related apoptosis signaling pathway involved in hepatic carcinoma process: suppression by carnosic acid nanoparticle.

Tang B, Tang F, Wang Z, Qi G, Liang X, Li B, Yuan S, Liu J, Yu S, He S.

Int J Nanomedicine. 2016 Nov 30;11:6401-6420. eCollection 2016.

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