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Items: 1 to 20 of 129

1.

Chemical genetic inhibition of Mps1 in stable human cell lines reveals novel aspects of Mps1 function in mitosis.

Sliedrecht T, Zhang C, Shokat KM, Kops GJ.

PLoS One. 2010 Apr 22;5(4):e10251. doi: 10.1371/journal.pone.0010251.

2.

Dissecting the role of MPS1 in chromosome biorientation and the spindle checkpoint through the small molecule inhibitor reversine.

Santaguida S, Tighe A, D'Alise AM, Taylor SS, Musacchio A.

J Cell Biol. 2010 Jul 12;190(1):73-87. doi: 10.1083/jcb.201001036.

3.

Monopolar spindle 1 (MPS1) kinase promotes production of closed MAD2 (C-MAD2) conformer and assembly of the mitotic checkpoint complex.

Tipton AR, Ji W, Sturt-Gillespie B, Bekier ME 2nd, Wang K, Taylor WR, Liu ST.

J Biol Chem. 2013 Dec 6;288(49):35149-58. doi: 10.1074/jbc.M113.522375. Epub 2013 Oct 22.

4.

Aurora B potentiates Mps1 activation to ensure rapid checkpoint establishment at the onset of mitosis.

Saurin AT, van der Waal MS, Medema RH, Lens SM, Kops GJ.

Nat Commun. 2011;2:316. doi: 10.1038/ncomms1319.

5.

Chemical genetics reveals a role for Mps1 kinase in kinetochore attachment during mitosis.

Jones MH, Huneycutt BJ, Pearson CG, Zhang C, Morgan G, Shokat K, Bloom K, Winey M.

Curr Biol. 2005 Jan 26;15(2):160-5.

6.

Autophosphorylation-dependent activation of human Mps1 is required for the spindle checkpoint.

Kang J, Chen Y, Zhao Y, Yu H.

Proc Natl Acad Sci U S A. 2007 Dec 18;104(51):20232-7. Epub 2007 Dec 14.

7.

Mps1 phosphorylates Borealin to control Aurora B activity and chromosome alignment.

Jelluma N, Brenkman AB, van den Broek NJ, Cruijsen CW, van Osch MH, Lens SM, Medema RH, Kops GJ.

Cell. 2008 Jan 25;132(2):233-46. doi: 10.1016/j.cell.2007.11.046.

8.

Mitotic Checkpoint Kinase Mps1 Has a Role in Normal Physiology which Impacts Clinical Utility.

Martinez R, Blasina A, Hallin JF, Hu W, Rymer I, Fan J, Hoffman RL, Murphy S, Marx M, Yanochko G, Trajkovic D, Dinh D, Timofeevski S, Zhu Z, Sun P, Lappin PB, Murray BW.

PLoS One. 2015 Sep 23;10(9):e0138616. doi: 10.1371/journal.pone.0138616. eCollection 2015.

9.

A small-molecule inhibitor of Mps1 blocks the spindle-checkpoint response to a lack of tension on mitotic chromosomes.

Dorer RK, Zhong S, Tallarico JA, Wong WH, Mitchison TJ, Murray AW.

Curr Biol. 2005 Jun 7;15(11):1070-6.

10.

Sustained Mps1 activity is required in mitosis to recruit O-Mad2 to the Mad1-C-Mad2 core complex.

Hewitt L, Tighe A, Santaguida S, White AM, Jones CD, Musacchio A, Green S, Taylor SS.

J Cell Biol. 2010 Jul 12;190(1):25-34. doi: 10.1083/jcb.201002133.

11.

Release of Mps1 from kinetochores is crucial for timely anaphase onset.

Jelluma N, Dansen TB, Sliedrecht T, Kwiatkowski NP, Kops GJ.

J Cell Biol. 2010 Oct 18;191(2):281-90. doi: 10.1083/jcb.201003038. Epub 2010 Oct 11.

12.

Small-molecule kinase inhibitors provide insight into Mps1 cell cycle function.

Kwiatkowski N, Jelluma N, Filippakopoulos P, Soundararajan M, Manak MS, Kwon M, Choi HG, Sim T, Deveraux QL, Rottmann S, Pellman D, Shah JV, Kops GJ, Knapp S, Gray NS.

Nat Chem Biol. 2010 May;6(5):359-68. doi: 10.1038/nchembio.345. Epub 2010 Apr 11.

13.

Characterisation of CCT271850, a selective, oral and potent MPS1 inhibitor, used to directly measure in vivo MPS1 inhibition vs therapeutic efficacy.

Faisal A, Mak GWY, Gurden MD, Xavier CPR, Anderhub SJ, Innocenti P, Westwood IM, Naud S, Hayes A, Box G, Valenti MR, De Haven Brandon AK, O'Fee L, Schmitt J, Woodward HL, Burke R, vanMontfort RLM, Blagg J, Raynaud FI, Eccles SA, Hoelder S, Linardopoulos S.

Br J Cancer. 2017 Apr 25;116(9):1166-1176. doi: 10.1038/bjc.2017.75. Epub 2017 Mar 23.

14.

Ablation of the spindle assembly checkpoint by a compound targeting Mps1.

Schmidt M, Budirahardja Y, Klompmaker R, Medema RH.

EMBO Rep. 2005 Sep;6(9):866-72.

15.

Spindle checkpoint-independent inhibition of mitotic chromosome segregation by Drosophila Mps1.

Althoff F, Karess RE, Lehner CF.

Mol Biol Cell. 2012 Jun;23(12):2275-91. doi: 10.1091/mbc.E12-02-0117. Epub 2012 May 2.

16.

TC Mps1 12, a novel Mps1 inhibitor, suppresses the growth of hepatocellular carcinoma cells via the accumulation of chromosomal instability.

Choi M, Min YH, Pyo J, Lee CW, Jang CY, Kim JE.

Br J Pharmacol. 2017 Jun;174(12):1810-1825. doi: 10.1111/bph.13782. Epub 2017 Apr 22.

PMID:
28299790
17.

The mitotic arrest in response to hypoxia and of polar bodies during early embryogenesis requires Drosophila Mps1.

Fischer MG, Heeger S, H├Ącker U, Lehner CF.

Curr Biol. 2004 Nov 23;14(22):2019-24.

18.

Chk2 prevents mitotic exit when the majority of kinetochores are unattached.

Petsalaki E, Zachos G.

J Cell Biol. 2014 May 12;205(3):339-56. doi: 10.1083/jcb.201310071. Epub 2014 May 5.

19.

Plk1 and Mps1 Cooperatively Regulate the Spindle Assembly Checkpoint in Human Cells.

von Schubert C, Cubizolles F, Bracher JM, Sliedrecht T, Kops GJPL, Nigg EA.

Cell Rep. 2015 Jul 7;12(1):66-78. doi: 10.1016/j.celrep.2015.06.007. Epub 2015 Jun 25.

20.

Mps1 kinase activity restrains anaphase during an unperturbed mitosis and targets Mad2 to kinetochores.

Tighe A, Staples O, Taylor S.

J Cell Biol. 2008 Jun 16;181(6):893-901. doi: 10.1083/jcb.200712028. Epub 2008 Jun 9.

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