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Items: 1 to 20 of 179

1.

Inhibition of beta-cell sodium-calcium exchange enhances glucose-dependent elevations in cytoplasmic calcium and insulin secretion.

Hamming KS, Soliman D, Webster NJ, Searle GJ, Matemisz LC, Liknes DA, Dai XQ, Pulinilkunnil T, Riedel MJ, Dyck JR, Macdonald PE, Light PE.

Diabetes. 2010 Jul;59(7):1686-93. doi: 10.2337/db09-0630. Epub 2010 Apr 22.

2.

Reactive oxygen species directly modify sodium-calcium exchanger activity in a splice variant-dependent manner.

Soliman D, Hamming KS, Matemisz LC, Light PE.

J Mol Cell Cardiol. 2009 Nov;47(5):595-602. doi: 10.1016/j.yjmcc.2009.05.011. Epub 2009 May 28.

PMID:
19481548
3.

Splice variant-dependent regulation of beta-cell sodium-calcium exchange by acyl-coenzyme As.

Hamming KS, Riedel MJ, Soliman D, Matemisz LC, Webster NJ, Searle GJ, MacDonald PE, Light PE.

Mol Endocrinol. 2008 Oct;22(10):2293-306. doi: 10.1210/me.2008-0053. Epub 2008 Jul 17.

4.

Heterozygous inactivation of the Na/Ca exchanger increases glucose-induced insulin release, β-cell proliferation, and mass.

Nguidjoe E, Sokolow S, Bigabwa S, Pachera N, D'Amico E, Allagnat F, Vanderwinden JM, Sener A, Manto M, Depreter M, Mast J, Joanny G, Montanya E, Rahier J, Cardozo AK, Eizirik DL, Schurmans S, Herchuelz A.

Diabetes. 2011 Aug;60(8):2076-85. doi: 10.2337/db10-0924. Epub 2011 Jun 9.

5.

Structural domains influencing sensitivity to isothiourea derivative inhibitor KB-R7943 in cardiac Nna(+)/Ca(2+) exchanger.

Iwamoto T, Kita S, Uehara A, Inoue Y, Taniguchi Y, Imanaga I, Shigekawa M.

Mol Pharmacol. 2001 Mar;59(3):524-31.

6.

Overactive bladder mediated by accelerated Ca2+ influx mode of Na+/Ca2+ exchanger in smooth muscle.

Yamamura H, Cole WC, Kita S, Hotta S, Murata H, Suzuki Y, Ohya S, Iwamoto T, Imaizumi Y.

Am J Physiol Cell Physiol. 2013 Aug 1;305(3):C299-308. doi: 10.1152/ajpcell.00065.2013. Epub 2013 May 22.

7.

Inhibition of sodium-calcium exchange by KB-R7943: Dodecylamine and sphingosine in transfected Chinese hamster ovary cells.

Condrescu M, Reeves JP.

Cell Calcium. 2010 May;47(5):404-11. doi: 10.1016/j.ceca.2010.02.004. Epub 2010 Mar 5.

PMID:
20206994
8.

Inhibition of Na+/Ca2+ exchange by KB-R7943: transport mode selectivity and antiarrhythmic consequences.

Elias CL, Lukas A, Shurraw S, Scott J, Omelchenko A, Gross GJ, Hnatowich M, Hryshko LV.

Am J Physiol Heart Circ Physiol. 2001 Sep;281(3):H1334-45.

9.

Na(+)/Ca (2+) exchange and the plasma membrane Ca(2+)-ATPase in β-cell function and diabetes.

Herchuelz A, Nguidjoe E, Jiang L, Pachera N.

Adv Exp Med Biol. 2013;961:385-94. doi: 10.1007/978-1-4614-4756-6_33. Review.

PMID:
23224897
10.

Sodium-calcium exchanger 1 regulates epithelial cell migration via calcium-dependent extracellular signal-regulated kinase signaling.

Balasubramaniam SL, Gopalakrishnapillai A, Gangadharan V, Duncan RL, Barwe SP.

J Biol Chem. 2015 May 15;290(20):12463-73. doi: 10.1074/jbc.M114.629519. Epub 2015 Mar 13.

11.

The Na+/Ca2+ exchange inhibitor 2-(2-(4-(4-nitrobenzyloxy)phenyl)ethyl)isothiourea methanesulfonate (KB-R7943) also blocks ryanodine receptors type 1 (RyR1) and type 2 (RyR2) channels.

Barrientos G, Bose DD, Feng W, Padilla I, Pessah IN.

Mol Pharmacol. 2009 Sep;76(3):560-8. doi: 10.1124/mol.109.057265. Epub 2009 Jun 9.

12.

SUMOylation regulates insulin exocytosis downstream of secretory granule docking in rodents and humans.

Dai XQ, Plummer G, Casimir M, Kang Y, Hajmrle C, Gaisano HY, Manning Fox JE, MacDonald PE.

Diabetes. 2011 Mar;60(3):838-47. doi: 10.2337/db10-0440. Epub 2011 Jan 24.

13.

Chronic administration of KB-R7943 induces up-regulation of cardiac NCX1.

Xu L, Kappler CS, Mani SK, Shepherd NR, Renaud L, Snider P, Conway SJ, Menick DR.

J Biol Chem. 2009 Oct 2;284(40):27265-72. doi: 10.1074/jbc.M109.022855. Epub 2009 Aug 6.

14.

Inhibition of pancreatic β-cell Ca2+/calmodulin-dependent protein kinase II reduces glucose-stimulated calcium influx and insulin secretion, impairing glucose tolerance.

Dadi PK, Vierra NC, Ustione A, Piston DW, Colbran RJ, Jacobson DA.

J Biol Chem. 2014 May 2;289(18):12435-45. doi: 10.1074/jbc.M114.562587. Epub 2014 Mar 13.

15.

Reverse-mode NCX current in mouse airway smooth muscle: Na(+) and voltage dependence, contributions to Ca(2+) influx and contraction, and altered expression in a model of allergen-induced hyperresponsiveness.

Rahman M, Inman M, Kiss L, Janssen LJ.

Acta Physiol (Oxf). 2012 Jun;205(2):279-91. doi: 10.1111/j.1748-1716.2011.02401.x. Epub 2012 Feb 11.

PMID:
22212361
16.

Imidazoline NNC77-0074 stimulates insulin secretion and inhibits glucagon release by control of Ca(2+)-dependent exocytosis in pancreatic alpha- and beta-cells.

Høy M, Olsen HL, Andersen HS, Bokvist K, Buschard K, Hansen J, Jacobsen P, Petersen JS, Rorsman P, Gromada J.

Eur J Pharmacol. 2003 Apr 11;466(1-2):213-21.

PMID:
12679159
17.

The novel Na(+)/Ca(2+) exchange inhibitor KB-R7943 also blocks native and expressed neuronal nicotinic receptors.

Pintado AJ, Herrero CJ, García AG, Montiel C.

Br J Pharmacol. 2000 Aug;130(8):1893-902.

18.

The reverse-mode NCX1 activity inhibitor KB-R7943 promotes prostate cancer cell death by activating the JNK pathway and blocking autophagic flux.

Long Z, Chen B, Liu Q, Zhao J, Yang Z, Dong X, Xia L, Huang S, Hu X, Song B, Li L.

Oncotarget. 2016 Jul 5;7(27):42059-42070. doi: 10.18632/oncotarget.9806.

19.

Effect of inhibition of Na(+)/Ca(2+) exchanger at the time of myocardial reperfusion on hypercontracture and cell death.

Inserte J, Garcia-Dorado D, Ruiz-Meana M, Padilla F, Barrabés JA, Pina P, Agulló L, Piper HM, Soler-Soler J.

Cardiovasc Res. 2002 Sep;55(4):739-48.

PMID:
12176123
20.

High potency inhibition of hERG potassium channels by the sodium-calcium exchange inhibitor KB-R7943.

Cheng H, Zhang Y, Du C, Dempsey CE, Hancox JC.

Br J Pharmacol. 2012 Apr;165(7):2260-73. doi: 10.1111/j.1476-5381.2011.01688.x.

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