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Ricin toxin hits a retrograde roadblock.

Seaman MN, Peden AA.

Cell. 2010 Apr 16;141(2):222-4. doi: 10.1016/j.cell.2010.03.044.


Antibody-mediated inhibition of ricin toxin retrograde transport.

Yermakova A, Klokk TI, Cole R, Sandvig K, Mantis NJ.

MBio. 2014 Apr 8;5(2):e00995. doi: 10.1128/mBio.00995-13.


Pathways followed by ricin and Shiga toxin into cells.

Sandvig K, Grimmer S, Lauvrak SU, Torgersen ML, Skretting G, van Deurs B, Iversen TG.

Histochem Cell Biol. 2002 Feb;117(2):131-41. Epub 2001 Nov 20. Review.


Inhibition of retrograde transport protects mice from lethal ricin challenge.

Stechmann B, Bai SK, Gobbo E, Lopez R, Merer G, Pinchard S, Panigai L, Tenza D, Raposo G, Beaumelle B, Sauvaire D, Gillet D, Johannes L, Barbier J.

Cell. 2010 Apr 16;141(2):231-42. doi: 10.1016/j.cell.2010.01.043.


Transport of protein toxins into cells: pathways used by ricin, cholera toxin and Shiga toxin.

Sandvig K, van Deurs B.

FEBS Lett. 2002 Oct 2;529(1):49-53. Review.


Identification of small-molecule inhibitors of ricin and shiga toxin using a cell-based high-throughput screen.

Wahome PG, Bai Y, Neal LM, Robertus JD, Mantis NJ.

Toxicon. 2010 Sep 1;56(3):313-23. doi: 10.1016/j.toxicon.2010.03.016. Epub 2010 Mar 27.


Entry of ricin and Shiga toxin into cells: molecular mechanisms and medical perspectives.

Sandvig K, van Deurs B.

EMBO J. 2000 Nov 15;19(22):5943-50. Review.


A Bispecific Antibody Promotes Aggregation of Ricin Toxin on Cell Surfaces and Alters Dynamics of Toxin Internalization and Trafficking.

Herrera C, Klokk TI, Cole R, Sandvig K, Mantis NJ.

PLoS One. 2016 Jun 14;11(6):e0156893. doi: 10.1371/journal.pone.0156893. eCollection 2016.


Vaccine-induced intestinal immunity to ricin toxin in the absence of secretory IgA.

Neal LM, McCarthy EA, Morris CR, Mantis NJ.

Vaccine. 2011 Jan 17;29(4):681-9. doi: 10.1016/j.vaccine.2010.11.030. Epub 2010 Nov 27.


Identification and characterization of small molecules that inhibit intracellular toxin transport.

Saenz JB, Doggett TA, Haslam DB.

Infect Immun. 2007 Sep;75(9):4552-61. Epub 2007 Jun 18.


Identification of small molecules that suppress ricin-induced stress-activated signaling pathways.

Wahome PG, Ahlawat S, Mantis NJ.

PLoS One. 2012;7(11):e49075. doi: 10.1371/journal.pone.0049075. Epub 2012 Nov 1.


Endocytosis and intracellular sorting of ricin and Shiga toxin.

Sandvig K, van Deurs B.

FEBS Lett. 1994 Jun 6;346(1):99-102. Review.


Evidence that the transport of ricin to the cytoplasm is independent of both Rab6A and COPI.

Chen A, AbuJarour RJ, Draper RK.

J Cell Sci. 2003 Sep 1;116(Pt 17):3503-10. Epub 2003 Jul 15.


Neutralizing Monoclonal Antibodies against Disparate Epitopes on Ricin Toxin's Enzymatic Subunit Interfere with Intracellular Toxin Transport.

Yermakova A, Klokk TI, O'Hara JM, Cole R, Sandvig K, Mantis NJ.

Sci Rep. 2016 Mar 7;6:22721. doi: 10.1038/srep22721.


Inhibitors of retrograde trafficking active against ricin and Shiga toxins also protect cells from several viruses, Leishmania and Chlamydiales.

Gupta N, Noël R, Goudet A, Hinsinger K, Michau A, Pons V, Abdelkafi H, Secher T, Shima A, Shtanko O, Sakurai Y, Cojean S, Pomel S, Liévin-Le Moal V, Leignel V, Herweg JA, Fischer A, Johannes L, Harrison K, Beard PM, Clayette P, Le Grand R, Rayner JO, Rudel T, Vacus J, Loiseau PM, Davey RA, Oswald E, Cintrat JC, Barbier J, Gillet D.

Chem Biol Interact. 2017 Apr 1;267:96-103. doi: 10.1016/j.cbi.2016.10.005. Epub 2016 Oct 3.


The induction of apoptosis by Shiga toxins and ricin.

Tesh VL.

Curr Top Microbiol Immunol. 2012;357:137-78. doi: 10.1007/82_2011_155. Review.


Antibody to ricin a chain hinders intracellular routing of toxin and protects cells even after toxin has been internalized.

Song K, Mize RR, Marrero L, Corti M, Kirk JM, Pincus SH.

PLoS One. 2013 Apr 24;8(4):e62417. doi: 10.1371/journal.pone.0062417. Print 2013.


Saporin and ricin A chain follow different intracellular routes to enter the cytosol of intoxicated cells.

Vago R, Marsden CJ, Lord JM, Ippoliti R, Flavell DJ, Flavell SU, Ceriotti A, Fabbrini MS.

FEBS J. 2005 Oct;272(19):4983-95.


Interplay between toxin transport and flotillin localization.

Pust S, Dyve AB, Torgersen ML, van Deurs B, Sandvig K.

PLoS One. 2010 Jan 22;5(1):e8844. doi: 10.1371/journal.pone.0008844.


Small-molecule inhibitors of ricin and Shiga toxins.

Wahome PG, Robertus JD, Mantis NJ.

Curr Top Microbiol Immunol. 2012;357:179-207. doi: 10.1007/82_2011_177. Review.


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