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Items: 1 to 20 of 89


Dissecting the unique role of the retinoblastoma tumor suppressor during cellular senescence.

Chicas A, Wang X, Zhang C, McCurrach M, Zhao Z, Mert O, Dickins RA, Narita M, Zhang M, Lowe SW.

Cancer Cell. 2010 Apr 13;17(4):376-87. doi: 10.1016/j.ccr.2010.01.023.


Distinct roles for p107 and p130 in Rb-independent cellular senescence.

Lehmann BD, Brooks AM, Paine MS, Chappell WH, McCubrey JA, Terrian DM.

Cell Cycle. 2008 May 1;7(9):1262-8. Epub 2008 Mar 7.


Loss of the retinoblastoma tumor suppressor: differential action on transcriptional programs related to cell cycle control and immune function.

Markey MP, Bergseid J, Bosco EE, Stengel K, Xu H, Mayhew CN, Schwemberger SJ, Braden WA, Jiang Y, Babcock GF, Jegga AG, Aronow BJ, Reed MF, Wang JY, Knudsen ES.

Oncogene. 2007 Sep 20;26(43):6307-18. Epub 2007 Apr 23.


Retinoblastoma family proteins have distinct functions in pulmonary epithelial cells in vivo critical for suppressing cell growth and tumorigenesis.

Simpson DS, Mason-Richie NA, Gettler CA, Wikenheiser-Brokamp KA.

Cancer Res. 2009 Nov 15;69(22):8733-41. doi: 10.1158/0008-5472.CAN-09-1359. Epub 2009 Nov 3.


Retinoblastoma/p107/p130 pocket proteins: protein dynamics and interactions with target gene promoters.

Stengel KR, Thangavel C, Solomon DA, Angus SP, Zheng Y, Knudsen ES.

J Biol Chem. 2009 Jul 17;284(29):19265-71. doi: 10.1074/jbc.M808740200. Epub 2009 Mar 11.


The specific role of pRb in p16 (INK4A) -mediated arrest of normal and malignant human breast cells.

Bazarov AV, Lee WJ, Bazarov I, Bosire M, Hines WC, Stankovich B, Chicas A, Lowe SW, Yaswen P.

Cell Cycle. 2012 Mar 1;11(5):1008-13. doi: 10.4161/cc.11.5.19492. Epub 2012 Mar 1.


The retinoblastoma gene family in cell cycle regulation and suppression of tumorigenesis.

Dannenberg JH, te Riele HP.

Results Probl Cell Differ. 2006;42:183-225. Review.


The histone demethylase Jarid1b (Kdm5b) is a novel component of the Rb pathway and associates with E2f-target genes in MEFs during senescence.

Nijwening JH, Geutjes EJ, Bernards R, Beijersbergen RL.

PLoS One. 2011;6(9):e25235. doi: 10.1371/journal.pone.0025235. Epub 2011 Sep 27.


The atypical E2F family member E2F7 couples the p53 and RB pathways during cellular senescence.

Aksoy O, Chicas A, Zeng T, Zhao Z, McCurrach M, Wang X, Lowe SW.

Genes Dev. 2012 Jul 15;26(14):1546-57. doi: 10.1101/gad.196238.112.


Loss of retinoblastoma but not p16 function allows bypass of replicative senescence in human fibroblasts.

Wei W, Herbig U, Wei S, Dutriaux A, Sedivy JM.

EMBO Rep. 2003 Nov;4(11):1061-6. Epub 2003 Oct 17.


Compensation by tumor suppressor genes during retinal development in mice and humans.

Donovan SL, Schweers B, Martins R, Johnson D, Dyer MA.

BMC Biol. 2006 May 3;4:14.


Expression of the retinoblastoma family of tumor suppressors during murine embryonic orofacial development.

Leezer JL, Hackmiller RC, Greene RM, Pisano MM.

Orthod Craniofac Res. 2003 Feb;6(1):32-47.


Requirement for p27(KIP1) in retinoblastoma protein-mediated senescence.

Alexander K, Hinds PW.

Mol Cell Biol. 2001 Jun;21(11):3616-31.


RB loss promotes aberrant ploidy by deregulating levels and activity of DNA replication factors.

Srinivasan SV, Mayhew CN, Schwemberger S, Zagorski W, Knudsen ES.

J Biol Chem. 2007 Aug 17;282(33):23867-77. Epub 2007 Jun 6.


Unique impact of RB loss on hepatic proliferation: tumorigenic stresses uncover distinct pathways of cell cycle control.

Reed CA, Mayhew CN, McClendon AK, Knudsen ES.

J Biol Chem. 2010 Jan 8;285(2):1089-96. doi: 10.1074/jbc.M109.043380. Epub 2009 Nov 2.


p41-Arc, a regulatory subunit of Arp2/3 complex, can induce premature senescence in the absence of p53 and Rb.

Yun UJ, Park SE, Shin DY.

Exp Mol Med. 2011 Jul 30;43(7):389-92. doi: 10.3858/emm.2011.43.7.042.


From G0 to S phase: a view of the roles played by the retinoblastoma (Rb) family members in the Rb-E2F pathway.

Sun A, Bagella L, Tutton S, Romano G, Giordano A.

J Cell Biochem. 2007 Dec 15;102(6):1400-4. Review.


The molecular basis of cancer suppression by the retinoblastoma gene.

Lee WH.

Princess Takamatsu Symp. 1989;20:159-70.


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