Similar articles for PMID: 20382541

Year	Number of Results
1998	1
1999	2
2000	7
2001	7
2002	9
2003	13
2004	8
2005	13
2006	8
2007	10
2008	9
2009	8
2010	3
2011	8
2012	2
2014	1
2016	2
2017	3
2020	1
2021	1
2024	0

1

Structure-activity relationships in a novel series of 7-substituted-aryl quinolines and 5-substituted-aryl benzothiazoles at the metabotropic glutamate receptor subtype 5.

Zhang P, Zou MF, Rodriguez AL, Conn PJ, Newman AH. Zhang P, et al. Bioorg Med Chem. 2010 May 1;18(9):3026-35. doi: 10.1016/j.bmc.2010.03.053. Epub 2010 Mar 27. Bioorg Med Chem. 2010. PMID: 20382541 Free PMC article.

2

Rational design of 7-arylquinolines as non-competitive metabotropic glutamate receptor subtype 5 antagonists.

Milbank JB, Knauer CS, Augelli-Szafran CE, Sakkab-Tan AT, Lin KK, Yamagata K, Hoffman JK, Zhuang N, Thomas J, Galatsis P, Wendt JA, Mickelson JW, Schwarz RD, Kinsora JJ, Lotarski SM, Stakich K, Gillespie KK, Lam WW, Mutlib AE. Milbank JB, et al. Bioorg Med Chem Lett. 2007 Aug 15;17(16):4415-8. doi: 10.1016/j.bmcl.2007.06.030. Epub 2007 Jun 10. Bioorg Med Chem Lett. 2007. PMID: 17590335

3

Structure-activity relationships comparing N-(6-methylpyridin-yl)-substituted aryl amides to 2-methyl-6-(substituted-arylethynyl)pyridines or 2-methyl-4-(substituted-arylethynyl)thiazoles as novel metabotropic glutamate receptor subtype 5 antagonists.

Kulkarni SS, Zou MF, Cao J, Deschamps JR, Rodriguez AL, Conn PJ, Newman AH. Kulkarni SS, et al. J Med Chem. 2009 Jun 11;52(11):3563-75. doi: 10.1021/jm900172f. J Med Chem. 2009. PMID: 19445453 Free PMC article.

4

SIB-1757 and SIB-1893: selective, noncompetitive antagonists of metabotropic glutamate receptor type 5.

Varney MA, Cosford ND, Jachec C, Rao SP, Sacaan A, Lin FF, Bleicher L, Santori EM, Flor PJ, Allgeier H, Gasparini F, Kuhn R, Hess SD, Veliçelebi G, Johnson EC. Varney MA, et al. J Pharmacol Exp Ther. 1999 Jul;290(1):170-81. J Pharmacol Exp Ther. 1999. PMID: 10381773

5

Synthesis and structure-activity relationships of 3-[(2-methyl-1,3-thiazol-4-yl)ethynyl]pyridine analogues as potent, noncompetitive metabotropic glutamate receptor subtype 5 antagonists; search for cocaine medications.

Iso Y, Grajkowska E, Wroblewski JT, Davis J, Goeders NE, Johnson KM, Sanker S, Roth BL, Tueckmantel W, Kozikowski AP. Iso Y, et al. J Med Chem. 2006 Feb 9;49(3):1080-100. doi: 10.1021/jm050570f. J Med Chem. 2006. PMID: 16451073

6

Mutational analysis and molecular modeling of the binding pocket of the metabotropic glutamate 5 receptor negative modulator 2-methyl-6-(phenylethynyl)-pyridine.

Malherbe P, Kratochwil N, Zenner MT, Piussi J, Diener C, Kratzeisen C, Fischer C, Porter RH. Malherbe P, et al. Mol Pharmacol. 2003 Oct;64(4):823-32. doi: 10.1124/mol.64.4.823. Mol Pharmacol. 2003. PMID: 14500738

7

Predicting compound selectivity by self-organizing maps: cross-activities of metabotropic glutamate receptor antagonists.

Noeske T, Sasse BC, Stark H, Parsons CG, Weil T, Schneider G. Noeske T, et al. ChemMedChem. 2006 Oct;1(10):1066-8. doi: 10.1002/cmdc.200600147. ChemMedChem. 2006. PMID: 16986201 No abstract available.

8

mGluR5 antagonists 2-methyl-6-(phenylethynyl)-pyridine and (E)-2-methyl-6-(2-phenylethenyl)-pyridine reduce traumatic neuronal injury in vitro and in vivo by antagonizing N-methyl-D-aspartate receptors.

Movsesyan VA, O'Leary DM, Fan L, Bao W, Mullins PG, Knoblach SM, Faden AI. Movsesyan VA, et al. J Pharmacol Exp Ther. 2001 Jan;296(1):41-7. J Pharmacol Exp Ther. 2001. PMID: 11123360

9

Neuroprotective activity of the mGluR5 antagonists MPEP and MTEP against acute excitotoxicity differs and does not reflect actions at mGluR5 receptors.

Lea PM 4th, Movsesyan VA, Faden AI. Lea PM 4th, et al. Br J Pharmacol. 2005 Jun;145(4):527-34. doi: 10.1038/sj.bjp.0706219. Br J Pharmacol. 2005. PMID: 15821750 Free PMC article.

10

Methoxyphenylethynyl, methoxypyridylethynyl and phenylethynyl derivatives of pyridine: synthesis, radiolabeling and evaluation of new PET ligands for metabotropic glutamate subtype 5 receptors.

Yu M, Tueckmantel W, Wang X, Zhu A, Kozikowski AP, Brownell AL. Yu M, et al. Nucl Med Biol. 2005 Aug;32(6):631-40. doi: 10.1016/j.nucmedbio.2005.05.004. Nucl Med Biol. 2005. PMID: 16026710

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