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The pivotal roles of mitochondria in cancer: Warburg and beyond and encouraging prospects for effective therapies.

Mathupala SP, Ko YH, Pedersen PL.

Biochim Biophys Acta. 2010 Jun-Jul;1797(6-7):1225-30. doi: 10.1016/j.bbabio.2010.03.025. Epub 2010 Apr 8. Review.


Hexokinase-2 bound to mitochondria: cancer's stygian link to the "Warburg Effect" and a pivotal target for effective therapy.

Mathupala SP, Ko YH, Pedersen PL.

Semin Cancer Biol. 2009 Feb;19(1):17-24. doi: 10.1016/j.semcancer.2008.11.006. Epub 2008 Dec 3. Review.


Modeling cancer glycolysis under hypoglycemia, and the role played by the differential expression of glycolytic isoforms.

Marín-Hernández A, López-Ramírez SY, Del Mazo-Monsalvo I, Gallardo-Pérez JC, Rodríguez-Enríquez S, Moreno-Sánchez R, Saavedra E.

FEBS J. 2014 Aug;281(15):3325-45. doi: 10.1111/febs.12864. Epub 2014 Jul 1.


The Warburg effect in tumor progression: mitochondrial oxidative metabolism as an anti-metastasis mechanism.

Lu J, Tan M, Cai Q.

Cancer Lett. 2015 Jan 28;356(2 Pt A):156-64. doi: 10.1016/j.canlet.2014.04.001. Epub 2014 Apr 13. Review.


Warburg effect increases steady-state ROS condition in cancer cells through decreasing their antioxidant capacities (anticancer effects of 3-bromopyruvate through antagonizing Warburg effect).

El Sayed SM, Mahmoud AA, El Sawy SA, Abdelaal EA, Fouad AM, Yousif RS, Hashim MS, Hemdan SB, Kadry ZM, Abdelmoaty MA, Gabr AG, Omran FM, Nabo MM, Ahmed NS.

Med Hypotheses. 2013 Nov;81(5):866-70. doi: 10.1016/j.mehy.2013.08.024. Epub 2013 Sep 3.


Hexokinase II integrates energy metabolism and cellular protection: Akting on mitochondria and TORCing to autophagy.

Roberts DJ, Miyamoto S.

Cell Death Differ. 2015 Feb;22(2):248-57. doi: 10.1038/cdd.2014.173. Epub 2014 Oct 17. Review. Erratum in: Cell Death Differ. 2015 Feb;22(2):364.


Mitochondria and cancer: Warburg addressed.

Wallace DC.

Cold Spring Harb Symp Quant Biol. 2005;70:363-74. Review.


Multiparameter metabolic analysis reveals a close link between attenuated mitochondrial bioenergetic function and enhanced glycolysis dependency in human tumor cells.

Wu M, Neilson A, Swift AL, Moran R, Tamagnine J, Parslow D, Armistead S, Lemire K, Orrell J, Teich J, Chomicz S, Ferrick DA.

Am J Physiol Cell Physiol. 2007 Jan;292(1):C125-36. Epub 2006 Sep 13.


Drivers of the Warburg phenotype.

Cairns RA.

Cancer J. 2015 Mar-Apr;21(2):56-61. doi: 10.1097/PPO.0000000000000106. Review.


[Targeting the gene of glucose metabolism for the treatment of advanced gliomas].

Oudard S, Miccoli L, Dutrillaux B, Poupon MF.

Bull Cancer. 1998 Jul;85(7):622-6. Review. French.


Reciprocal metabolic reprogramming through lactate shuttle coordinately influences tumor-stroma interplay.

Fiaschi T, Marini A, Giannoni E, Taddei ML, Gandellini P, De Donatis A, Lanciotti M, Serni S, Cirri P, Chiarugi P.

Cancer Res. 2012 Oct 1;72(19):5130-40. doi: 10.1158/0008-5472.CAN-12-1949. Epub 2012 Jul 31.


Gliomas are driven by glycolysis: putative roles of hexokinase, oxidative phosphorylation and mitochondrial ultrastructure.

Oudard S, Boitier E, Miccoli L, Rousset S, Dutrillaux B, Poupon MF.

Anticancer Res. 1997 May-Jun;17(3C):1903-11.


p63 supports aerobic respiration through hexokinase II.

Viticchiè G, Agostini M, Lena AM, Mancini M, Zhou H, Zolla L, Dinsdale D, Saintigny G, Melino G, Candi E.

Proc Natl Acad Sci U S A. 2015 Sep 15;112(37):11577-82. doi: 10.1073/pnas.1508871112. Epub 2015 Aug 31.


Mitochondrial metabolism in cancer metastasis: visualizing tumor cell mitochondria and the "reverse Warburg effect" in positive lymph node tissue.

Sotgia F, Whitaker-Menezes D, Martinez-Outschoorn UE, Flomenberg N, Birbe RC, Witkiewicz AK, Howell A, Philp NJ, Pestell RG, Lisanti MP.

Cell Cycle. 2012 Apr 1;11(7):1445-54. doi: 10.4161/cc.19841. Epub 2012 Apr 1.


Effect of the antitumoral alkylating agent 3-bromopyruvate on mitochondrial respiration: role of mitochondrially bound hexokinase.

Rodrigues-Ferreira C, da Silva AP, Galina A.

J Bioenerg Biomembr. 2012 Feb;44(1):39-49. doi: 10.1007/s10863-012-9413-8. Epub 2012 Feb 10.


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