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Items: 1 to 20 of 125

2.

Nobiletin, a citrus flavonoid, improves memory impairment and Abeta pathology in a transgenic mouse model of Alzheimer's disease.

Onozuka H, Nakajima A, Matsuzaki K, Shin RW, Ogino K, Saigusa D, Tetsu N, Yokosuka A, Sashida Y, Mimaki Y, Yamakuni T, Ohizumi Y.

J Pharmacol Exp Ther. 2008 Sep;326(3):739-44. doi: 10.1124/jpet.108.140293. Epub 2008 Jun 10.

3.

Nobiletin improves brain ischemia-induced learning and memory deficits through stimulation of CaMKII and CREB phosphorylation.

Yamamoto Y, Shioda N, Han F, Moriguchi S, Nakajima A, Yokosuka A, Mimaki Y, Sashida Y, Yamakuni T, Ohizumi Y, Fukunaga K.

Brain Res. 2009 Oct 27;1295:218-29. doi: 10.1016/j.brainres.2009.07.081. Epub 2009 Jul 30.

PMID:
19646972
4.

Arginine vasopressin prevents amyloid beta protein-induced impairment of long-term potentiation in rat hippocampus in vivo.

Jing W, Guo F, Cheng L, Zhang JF, Qi JS.

Neurosci Lett. 2009 Feb 6;450(3):306-10. doi: 10.1016/j.neulet.2008.11.053. Epub 2008 Nov 28.

PMID:
19059464
5.

A traditional medicinal herb Paeonia suffruticosa and its active constituent 1,2,3,4,6-penta-O-galloyl-beta-D-glucopyranose have potent anti-aggregation effects on Alzheimer's amyloid beta proteins in vitro and in vivo.

Fujiwara H, Tabuchi M, Yamaguchi T, Iwasaki K, Furukawa K, Sekiguchi K, Ikarashi Y, Kudo Y, Higuchi M, Saido TC, Maeda S, Takashima A, Hara M, Yaegashi N, Kase Y, Arai H.

J Neurochem. 2009 Jun;109(6):1648-57. doi: 10.1111/j.1471-4159.2009.06069.x. Epub 2009 May 7.

6.

Nobiletin restoring beta-amyloid-impaired CREB phosphorylation rescues memory deterioration in Alzheimer's disease model rats.

Matsuzaki K, Yamakuni T, Hashimoto M, Haque AM, Shido O, Mimaki Y, Sashida Y, Ohizumi Y.

Neurosci Lett. 2006 Jun 12;400(3):230-4. Epub 2006 Apr 3.

PMID:
16581185
7.

Imipramine, in part through tumor necrosis factor alpha inhibition, prevents cognitive decline and beta-amyloid accumulation in a mouse model of Alzheimer's disease.

Chavant F, Deguil J, Pain S, Ingrand I, Milin S, Fauconneau B, Pérault-Pochat MC, Lafay-Chebassier C.

J Pharmacol Exp Ther. 2010 Feb;332(2):505-14. doi: 10.1124/jpet.109.162164. Epub 2009 Nov 4.

8.

4'-Demethylnobiletin, a bioactive metabolite of nobiletin enhancing PKA/ERK/CREB signaling, rescues learning impairment associated with NMDA receptor antagonism via stimulation of the ERK cascade.

Al Rahim M, Nakajima A, Saigusa D, Tetsu N, Maruyama Y, Shibuya M, Yamakoshi H, Tomioka Y, Iwabuchi Y, Ohizumi Y, Yamakuni T.

Biochemistry. 2009 Aug 18;48(32):7713-21. doi: 10.1021/bi901088w.

PMID:
19601643
9.

Progressive age-related development of Alzheimer-like pathology in APP/PS1 mice.

Trinchese F, Liu S, Battaglia F, Walter S, Mathews PM, Arancio O.

Ann Neurol. 2004 Jun;55(6):801-14.

PMID:
15174014
10.
11.

Caffeine protects Alzheimer's mice against cognitive impairment and reduces brain beta-amyloid production.

Arendash GW, Schleif W, Rezai-Zadeh K, Jackson EK, Zacharia LC, Cracchiolo JR, Shippy D, Tan J.

Neuroscience. 2006 Nov 3;142(4):941-52. Epub 2006 Aug 28.

PMID:
16938404
12.

Pharmacological action of nobiletin, a component of AURANTII NOBILIS PERICARPIUM with anti-dementia activity, and its application for development of functional foods.

Yamakuni T, Nakajima A, Ohizumi Y.

Nihon Yakurigaku Zasshi. 2008 Sep;132(3):155-9. doi: 10.1254/fpj.132.155. Review. Japanese. No abstract available.

PMID:
18787297
13.

Adenosine A2A receptor blockade prevents synaptotoxicity and memory dysfunction caused by beta-amyloid peptides via p38 mitogen-activated protein kinase pathway.

Canas PM, Porciúncula LO, Cunha GM, Silva CG, Machado NJ, Oliveira JM, Oliveira CR, Cunha RA.

J Neurosci. 2009 Nov 25;29(47):14741-51. doi: 10.1523/JNEUROSCI.3728-09.2009.

14.

Nobiletin, a citrus flavonoid, improves cognitive impairment and reduces soluble Aβ levels in a triple transgenic mouse model of Alzheimer's disease (3XTg-AD).

Nakajima A, Aoyama Y, Shin EJ, Nam Y, Kim HC, Nagai T, Yokosuka A, Mimaki Y, Yokoi T, Ohizumi Y, Yamada K.

Behav Brain Res. 2015 Aug 1;289:69-77. doi: 10.1016/j.bbr.2015.04.028. Epub 2015 Apr 22.

PMID:
25913833
15.

GEPT extract reduces Abeta deposition by regulating the balance between production and degradation of Abeta in APPV717I transgenic mice.

Tian J, Shi J, Zhang L, Yin J, Hu Q, Xu Y, Sheng S, Wang P, Ren Y, Wang R, Wang Y.

Curr Alzheimer Res. 2009 Apr;6(2):118-31.

PMID:
19355846
16.

Beneficial effects of quetiapine in a transgenic mouse model of Alzheimer's disease.

He J, Luo H, Yan B, Yu Y, Wang H, Wei Z, Zhang Y, Xu H, Tempier A, Li X, Li XM.

Neurobiol Aging. 2009 Aug;30(8):1205-16. Epub 2008 Feb 20.

PMID:
18079026
17.

Nobiletin, a citrus flavonoid with neurotrophic action, augments protein kinase A-mediated phosphorylation of the AMPA receptor subunit, GluR1, and the postsynaptic receptor response to glutamate in murine hippocampus.

Matsuzaki K, Miyazaki K, Sakai S, Yawo H, Nakata N, Moriguchi S, Fukunaga K, Yokosuka A, Sashida Y, Mimaki Y, Yamakuni T, Ohizumi Y.

Eur J Pharmacol. 2008 Jan 14;578(2-3):194-200. Epub 2007 Oct 2.

PMID:
17976577
18.

A novel diol-derivative of chalcone produced by bioconversion, 3-(2,3-dihydroxyphenyl)-1-phenylpropan-1-one, activates PKA/MEK/ERK signaling and antagonizes Abeta-inhibition of the cascade in cultured rat CNS neurons.

Al Rahim M, Nakajima A, Misawa N, Shindo K, Adachi K, Shizuri Y, Ohizumi Y, Yamakuni T.

Eur J Pharmacol. 2008 Dec 14;600(1-3):10-7. doi: 10.1016/j.ejphar.2008.09.046. Epub 2008 Oct 9.

PMID:
18948095
19.

Conditional inactivation of presenilin 1 prevents amyloid accumulation and temporarily rescues contextual and spatial working memory impairments in amyloid precursor protein transgenic mice.

Saura CA, Chen G, Malkani S, Choi SY, Takahashi RH, Zhang D, Gouras GK, Kirkwood A, Morris RG, Shen J.

J Neurosci. 2005 Jul 20;25(29):6755-64.

20.

Orally available compound prevents deficits in memory caused by the Alzheimer amyloid-beta oligomers.

Townsend M, Cleary JP, Mehta T, Hofmeister J, Lesne S, O'Hare E, Walsh DM, Selkoe DJ.

Ann Neurol. 2006 Dec;60(6):668-76.

PMID:
17192927

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