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Items: 1 to 20 of 130

1.

Deletion of microsomal prostaglandin E synthase-1 does not alter ozone-induced airway hyper-responsiveness.

Wang M, Cooper PR, Jiang M, Zhao H, Hui Y, Yao Y, Tate JC, Damera G, Lawson JA, Jester WF Jr, Haczku A, Panettieri RA Jr, FitzGerald GA.

J Pharmacol Exp Ther. 2010 Jul;334(1):63-8. doi: 10.1124/jpet.110.166678. Epub 2010 Apr 6.

2.

Deletion of microsomal prostaglandin E synthase-1 augments prostacyclin and retards atherogenesis.

Wang M, Zukas AM, Hui Y, Ricciotti E, Puré E, FitzGerald GA.

Proc Natl Acad Sci U S A. 2006 Sep 26;103(39):14507-12. Epub 2006 Sep 14.

3.

Effects of AF3442 [N-(9-ethyl-9H-carbazol-3-yl)-2-(trifluoromethyl)benzamide], a novel inhibitor of human microsomal prostaglandin E synthase-1, on prostanoid biosynthesis in human monocytes in vitro.

Bruno A, Di Francesco L, Coletta I, Mangano G, Alisi MA, Polenzani L, Milanese C, Anzellotti P, Ricciotti E, Dovizio M, Di Francesco A, Tacconelli S, Capone ML, Patrignani P.

Biochem Pharmacol. 2010 Apr 1;79(7):974-81. doi: 10.1016/j.bcp.2009.11.011. Epub 2009 Nov 27.

PMID:
19925781
4.

Microsomal prostaglandin E synthase-1 deletion suppresses oxidative stress and angiotensin II-induced abdominal aortic aneurysm formation.

Wang M, Lee E, Song W, Ricciotti E, Rader DJ, Lawson JA, Puré E, FitzGerald GA.

Circulation. 2008 Mar 11;117(10):1302-9. doi: 10.1161/CIRCULATIONAHA.107.731398. Epub 2008 Feb 19.

5.

Deletion of microsomal prostaglandin E2 (PGE2) synthase-1 reduces inducible and basal PGE2 production and alters the gastric prostanoid profile.

Boulet L, Ouellet M, Bateman KP, Ethier D, Percival MD, Riendeau D, Mancini JA, Méthot N.

J Biol Chem. 2004 May 28;279(22):23229-37. Epub 2004 Mar 11.

7.

Myrtucommulone, a natural acylphloroglucinol, inhibits microsomal prostaglandin E(2) synthase-1.

Koeberle A, Pollastro F, Northoff H, Werz O.

Br J Pharmacol. 2009 Mar;156(6):952-61. doi: 10.1111/j.1476-5381.2009.00070.x.

8.

Microsomal prostaglandin e2 synthase-1 modulates the response to vascular injury.

Wang M, Ihida-Stansbury K, Kothapalli D, Tamby MC, Yu Z, Chen L, Grant G, Cheng Y, Lawson JA, Assoian RK, Jones PL, Fitzgerald GA.

Circulation. 2011 Feb 15;123(6):631-9. doi: 10.1161/CIRCULATIONAHA.110.973685. Epub 2011 Jan 31.

9.

Microsomal prostaglandin E2 synthase-1 deletion leads to adverse left ventricular remodeling after myocardial infarction.

Degousee N, Fazel S, Angoulvant D, Stefanski E, Pawelzik SC, Korotkova M, Arab S, Liu P, Lindsay TF, Zhuo S, Butany J, Li RK, Audoly L, Schmidt R, Angioni C, Geisslinger G, Jakobsson PJ, Rubin BB.

Circulation. 2008 Apr 1;117(13):1701-10. doi: 10.1161/CIRCULATIONAHA.107.749739. Epub 2008 Mar 17.

11.

Microsomal prostaglandin E synthase-1 inhibition in cardiovascular inflammatory disease.

Wang M, Song WL, Cheng Y, Fitzgerald GA.

J Intern Med. 2008 May;263(5):500-5. doi: 10.1111/j.1365-2796.2008.01938.x. Review.

12.

Distinction of microsomal prostaglandin E synthase-1 (mPGES-1) inhibition from cyclooxygenase-2 inhibition in cells using a novel, selective mPGES-1 inhibitor.

Mbalaviele G, Pauley AM, Shaffer AF, Zweifel BS, Mathialagan S, Mnich SJ, Nemirovskiy OV, Carter J, Gierse JK, Wang JL, Vazquez ML, Moore WM, Masferrer JL.

Biochem Pharmacol. 2010 May 15;79(10):1445-54. doi: 10.1016/j.bcp.2010.01.003. Epub 2010 Jan 11.

PMID:
20067770
13.

Prostaglandin E(2) exerts homeostatic regulation of pulmonary vascular remodeling in allergic airway inflammation.

Lundequist A, Nallamshetty SN, Xing W, Feng C, Laidlaw TM, Uematsu S, Akira S, Boyce JA.

J Immunol. 2010 Jan 1;184(1):433-41. doi: 10.4049/jimmunol.0902835.

14.

The molecular pharmacology and in vivo activity of 2-(4-chloro-6-(2,3-dimethylphenylamino)pyrimidin-2-ylthio)octanoic acid (YS121), a dual inhibitor of microsomal prostaglandin E2 synthase-1 and 5-lipoxygenase.

Koeberle A, Rossi A, Zettl H, Pergola C, Dehm F, Bauer J, Greiner C, Reckel S, Hoernig C, Northoff H, Bernhard F, Dötsch V, Sautebin L, Schubert-Zsilavecz M, Werz O.

J Pharmacol Exp Ther. 2010 Mar;332(3):840-8. doi: 10.1124/jpet.109.160663. Epub 2009 Nov 24.

15.
16.

MF63 [2-(6-chloro-1H-phenanthro[9,10-d]imidazol-2-yl)-isophthalonitrile], a selective microsomal prostaglandin E synthase-1 inhibitor, relieves pyresis and pain in preclinical models of inflammation.

Xu D, Rowland SE, Clark P, Giroux A, Côté B, Guiral S, Salem M, Ducharme Y, Friesen RW, Méthot N, Mancini J, Audoly L, Riendeau D.

J Pharmacol Exp Ther. 2008 Sep;326(3):754-63. doi: 10.1124/jpet.108.138776. Epub 2008 Jun 4.

17.
18.

Microsomal prostaglandin E synthase-1 is involved in multiple steps of colon carcinogenesis.

Sasaki Y, Kamei D, Ishikawa Y, Ishii T, Uematsu S, Akira S, Murakami M, Hara S.

Oncogene. 2012 Jun 14;31(24):2943-52. doi: 10.1038/onc.2011.472. Epub 2011 Oct 10.

PMID:
21986945
19.

Prostaglandin E2 produced by microsomal prostaglandin E synthase-1 regulates the onset and the maintenance of wakefulness.

Takemiya T.

Neurochem Int. 2011 Nov;59(6):922-4. doi: 10.1016/j.neuint.2011.07.001. Epub 2011 Jul 19.

PMID:
21784115
20.

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