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Items: 1 to 20 of 105

1.

PlGF blockade does not inhibit angiogenesis during primary tumor growth.

Bais C, Wu X, Yao J, Yang S, Crawford Y, McCutcheon K, Tan C, Kolumam G, Vernes JM, Eastham-Anderson J, Haughney P, Kowanetz M, Hagenbeek T, Kasman I, Reslan HB, Ross J, Van Bruggen N, Carano RA, Meng YJ, Hongo JA, Stephan JP, Shibuya M, Ferrara N.

Cell. 2010 Apr 2;141(1):166-77. doi: 10.1016/j.cell.2010.01.033.

2.

Expression of a functional VEGFR-1 in tumor cells is a major determinant of anti-PlGF antibodies efficacy.

Yao J, Wu X, Zhuang G, Kasman IM, Vogt T, Phan V, Shibuya M, Ferrara N, Bais C.

Proc Natl Acad Sci U S A. 2011 Jul 12;108(28):11590-5. doi: 10.1073/pnas.1109029108. Epub 2011 Jun 27.

3.

Redundant roles of VEGF-B and PlGF during selective VEGF-A blockade in mice.

Malik AK, Baldwin ME, Peale F, Fuh G, Liang WC, Lowman H, Meng G, Ferrara N, Gerber HP.

Blood. 2006 Jan 15;107(2):550-7. Epub 2005 Sep 27.

PMID:
16189273
4.

Tumor cell-derived placental growth factor sensitizes antiangiogenic and antitumor effects of anti-VEGF drugs.

Hedlund EM, Yang X, Zhang Y, Yang Y, Shibuya M, Zhong W, Sun B, Liu Y, Hosaka K, Cao Y.

Proc Natl Acad Sci U S A. 2013 Jan 8;110(2):654-9. doi: 10.1073/pnas.1209310110. Epub 2012 Dec 24.

5.

Synergism between vascular endothelial growth factor and placental growth factor contributes to angiogenesis and plasma extravasation in pathological conditions.

Carmeliet P, Moons L, Luttun A, Vincenti V, Compernolle V, De Mol M, Wu Y, Bono F, Devy L, Beck H, Scholz D, Acker T, DiPalma T, Dewerchin M, Noel A, Stalmans I, Barra A, Blacher S, VandenDriessche T, Ponten A, Eriksson U, Plate KH, Foidart JM, Schaper W, Charnock-Jones DS, Hicklin DJ, Herbert JM, Collen D, Persico MG.

Nat Med. 2001 May;7(5):575-83.

6.

Placental growth factor neutralising antibodies give limited anti-angiogenic effects in an in vitro organotypic angiogenesis model.

Brave SR, Eberlein C, Shibuya M, Wedge SR, Barry ST.

Angiogenesis. 2010 Dec;13(4):337-47. doi: 10.1007/s10456-010-9190-0. Epub 2010 Oct 16.

PMID:
20953695
7.

Specific blockade of VEGF and HER2 pathways results in greater growth inhibition of breast cancer xenografts that overexpress HER2.

Le XF, Mao W, Lu C, Thornton A, Heymach JV, Sood AK, Bast RC Jr.

Cell Cycle. 2008 Dec;7(23):3747-58. Epub 2008 Dec 16.

8.

Anti-placental growth factor reduces bone metastasis by blocking tumor cell engraftment and osteoclast differentiation.

Coenegrachts L, Maes C, Torrekens S, Van Looveren R, Mazzone M, Guise TA, Bouillon R, Stassen JM, Carmeliet P, Carmeliet G.

Cancer Res. 2010 Aug 15;70(16):6537-47. doi: 10.1158/0008-5472.CAN-09-4092. Epub 2010 Aug 3.

9.

Anti-PlGF inhibits growth of VEGF(R)-inhibitor-resistant tumors without affecting healthy vessels.

Fischer C, Jonckx B, Mazzone M, Zacchigna S, Loges S, Pattarini L, Chorianopoulos E, Liesenborghs L, Koch M, De Mol M, Autiero M, Wyns S, Plaisance S, Moons L, van Rooijen N, Giacca M, Stassen JM, Dewerchin M, Collen D, Carmeliet P.

Cell. 2007 Nov 2;131(3):463-75.

10.

Vascular endothelial growth factor-dependent spatiotemporal dual roles of placental growth factor in modulation of angiogenesis and tumor growth.

Yang X, Zhang Y, Yang Y, Lim S, Cao Z, Rak J, Cao Y.

Proc Natl Acad Sci U S A. 2013 Aug 20;110(34):13932-7. doi: 10.1073/pnas.1309629110. Epub 2013 Aug 5.

11.

Further pharmacological and genetic evidence for the efficacy of PlGF inhibition in cancer and eye disease.

Van de Veire S, Stalmans I, Heindryckx F, Oura H, Tijeras-Raballand A, Schmidt T, Loges S, Albrecht I, Jonckx B, Vinckier S, Van Steenkiste C, Tugues S, Rolny C, De Mol M, Dettori D, Hainaud P, Coenegrachts L, Contreres JO, Van Bergen T, Cuervo H, Xiao WH, Le Henaff C, Buysschaert I, Kharabi Masouleh B, Geerts A, Schomber T, Bonnin P, Lambert V, Haustraete J, Zacchigna S, Rakic JM, Jiménez W, Noël A, Giacca M, Colle I, Foidart JM, Tobelem G, Morales-Ruiz M, Vilar J, Maxwell P, Vinores SA, Carmeliet G, Dewerchin M, Claesson-Welsh L, Dupuy E, Van Vlierberghe H, Christofori G, Mazzone M, Detmar M, Collen D, Carmeliet P.

Cell. 2010 Apr 2;141(1):178-90. doi: 10.1016/j.cell.2010.02.039.

12.

Placental growth factor upregulation is a host response to antiangiogenic therapy.

Bagley RG, Ren Y, Weber W, Yao M, Kurtzberg L, Pinckney J, Bangari D, Nguyen C, Brondyk W, Kaplan J, Teicher BA.

Clin Cancer Res. 2011 Mar 1;17(5):976-88. doi: 10.1158/1078-0432.CCR-10-2687. Epub 2011 Feb 22.

13.
15.

Combined Anti-PLGF and Anti-Endostatin Treatments Inhibit Ocular Hemangiomas.

Jiang H, Wu X, Wang H, Huang C, Zhang L.

Cell Physiol Biochem. 2015;36(3):930-6. doi: 10.1159/000430267. Epub 2015 Jun 12.

16.

Revascularization of ischemic tissues by PlGF treatment, and inhibition of tumor angiogenesis, arthritis and atherosclerosis by anti-Flt1.

Luttun A, Tjwa M, Moons L, Wu Y, Angelillo-Scherrer A, Liao F, Nagy JA, Hooper A, Priller J, De Klerck B, Compernolle V, Daci E, Bohlen P, Dewerchin M, Herbert JM, Fava R, Matthys P, Carmeliet G, Collen D, Dvorak HF, Hicklin DJ, Carmeliet P.

Nat Med. 2002 Aug;8(8):831-40. Epub 2002 Jul 1.

PMID:
12091877
17.

Placenta growth factor-1 antagonizes VEGF-induced angiogenesis and tumor growth by the formation of functionally inactive PlGF-1/VEGF heterodimers.

Eriksson A, Cao R, Pawliuk R, Berg SM, Tsang M, Zhou D, Fleet C, Tritsaris K, Dissing S, Leboulch P, Cao Y.

Cancer Cell. 2002 Feb;1(1):99-108.

18.

Inhibition of placenta growth factor with TB-403: a novel antiangiogenic cancer therapy.

Nielsen DL, Sengeløv L.

Expert Opin Biol Ther. 2012 Jun;12(6):795-804. doi: 10.1517/14712598.2012.679655. Epub 2012 Apr 16. Review.

PMID:
22506966
19.

Tumor angiogenesis and anti-angiogenic therapies.

Shahneh FZ, Baradaran B, Zamani F, Aghebati-Maleki L.

Hum Antibodies. 2013;22(1-2):15-9. doi: 10.3233/HAB-130267. Review.

PMID:
24284305
20.

Human choriocarcinomas: placental growth factor-dependent preclinical tumor models.

Bagley RG, Ren Y, Kurtzberg L, Weber W, Bangari D, Brondyk W, Teicher BA.

Int J Oncol. 2012 Feb;40(2):479-86. doi: 10.3892/ijo.2011.1257. Epub 2011 Nov 10.

PMID:
22075622

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