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Items: 1 to 20 of 98

1.

Synthesis of labeled BCX-4208, a potent inhibitor of purine nucleoside phosphorylase.

Kamath VP, Juarez-Brambila JJ, Morris PE Jr.

Drug Test Anal. 2009 Mar;1(3):125-7. doi: 10.1002/dta.24.

PMID:
20355185
2.

One-third-the-sites transition-state inhibitors for purine nucleoside phosphorylase.

Miles RW, Tyler PC, Furneaux RH, Bagdassarian CK, Schramm VL.

Biochemistry. 1998 Jun 16;37(24):8615-21.

PMID:
9628722
3.

Purine nucleoside phosphorylase inhibitor BCX-1777 (Immucillin-H)--a novel potent and orally active immunosuppressive agent.

Bantia S, Miller PJ, Parker CD, Ananth SL, Horn LL, Kilpatrick JM, Morris PE, Hutchison TL, Montgomery JA, Sandhu JS.

Int Immunopharmacol. 2001 Jun;1(6):1199-210.

PMID:
11407314
4.

Synthesis of a transition state analogue inhibitor of purine nucleoside phosphorylase via the Mannich reaction.

Evans GB, Furneaux RH, Tyler PC, Schramm VL.

Org Lett. 2003 Oct 2;5(20):3639-40.

PMID:
14507192
5.

Intravenous and oral pharmacokinetic study of BCX-1777, a novel purine nucleoside phosphorylase transition-state inhibitor. In vivo effects on blood 2'-deoxyguanosine in primates.

Kilpatrick JM, Morris PE, Serota DG Jr, Phillips D, Moore DR, Bennett JC, Babu YS.

Int Immunopharmacol. 2003 Apr;3(4):541-8.

PMID:
12689658
6.

Over-the-barrier transition state analogues and crystal structure with Mycobacterium tuberculosis purine nucleoside phosphorylase.

Lewandowicz A, Shi W, Evans GB, Tyler PC, Furneaux RH, Basso LA, Santos DS, Almo SC, Schramm VL.

Biochemistry. 2003 May 27;42(20):6057-66.

PMID:
12755607
7.

Synthesis of analogs of forodesine HCl, a human purine nucleoside phosphorylase inhibitor-Part I.

Kamath VP, Xue J, Juarez-Brambila JJ, Morris CB, Ganorkar R, Morris PE Jr.

Bioorg Med Chem Lett. 2009 May 15;19(10):2624-6. doi: 10.1016/j.bmcl.2009.04.017. Epub 2009 Apr 9.

PMID:
19386498
8.

Atomic dissection of the hydrogen bond network for transition-state analogue binding to purine nucleoside phosphorylase.

Kicska GA, Tyler PC, Evans GB, Furneaux RH, Shi W, Fedorov A, Lewandowicz A, Cahill SM, Almo SC, Schramm VL.

Biochemistry. 2002 Dec 10;41(49):14489-98.

PMID:
12463747
9.

Synthesis of analogs of forodesine HCl, a human purine nucleoside phosphorylase inhibitor-Part II.

Kamath VP, Xue J, Juarez-Brambila JJ.

Bioorg Med Chem Lett. 2009 May 15;19(10):2627-9. doi: 10.1016/j.bmcl.2009.04.018. Epub 2009 Apr 9.

PMID:
19386496
10.

Targeting the polyamine pathway with transition-state analogue inhibitors of 5'-methylthioadenosine phosphorylase.

Evans GB, Furneaux RH, Schramm VL, Singh V, Tyler PC.

J Med Chem. 2004 Jun 3;47(12):3275-81.

PMID:
15163207
11.

Transition states and inhibitors of the purine nucleoside phosphorylase family.

Taylor Ringia EA, Schramm VL.

Curr Top Med Chem. 2005;5(13):1237-58. Review.

PMID:
16305529
12.

An efficient and large-scale enantioselective synthesis of PNP405: a purine nucleoside phosphorylase inhibitor.

Prashad M, Har D, Chen L, Kim HY, Repic O, Blacklock TJ.

J Org Chem. 2002 Sep 20;67(19):6612-7.

PMID:
12227788
13.

Azetidine based transition state analogue inhibitors of N-ribosyl hydrolases and phosphorylases.

Evans GB, Furneaux RH, Greatrex B, Murkin AS, Schramm VL, Tyler PC.

J Med Chem. 2008 Feb 28;51(4):948-56. doi: 10.1021/jm701265n. Epub 2008 Feb 6.

PMID:
18251493
14.

Exploring structure-activity relationships of transition state analogues of human purine nucleoside phosphorylase.

Evans GB, Furneaux RH, Lewandowicz A, Schramm VL, Tyler PC.

J Med Chem. 2003 Jul 17;46(15):3412-23.

PMID:
12852771
15.

L-Enantiomers of transition state analogue inhibitors bound to human purine nucleoside phosphorylase.

Rinaldo-Matthis A, Murkin AS, Ramagopal UA, Clinch K, Mee SP, Evans GB, Tyler PC, Furneaux RH, Almo SC, Schramm VL.

J Am Chem Soc. 2008 Jan 23;130(3):842-4. Epub 2007 Dec 23.

16.

Synthesis of second-generation transition state analogues of human purine nucleoside phosphorylase.

Evans GB, Furneaux RH, Lewandowicz A, Schramm VL, Tyler PC.

J Med Chem. 2003 Nov 20;46(24):5271-6.

PMID:
14613329
17.

Transition state structure of purine nucleoside phosphorylase and principles of atomic motion in enzymatic catalysis.

Fedorov A, Shi W, Kicska G, Fedorov E, Tyler PC, Furneaux RH, Hanson JC, Gainsford GJ, Larese JZ, Schramm VL, Almo SC.

Biochemistry. 2001 Jan 30;40(4):853-60.

PMID:
11170405
18.

Forodesine (BCX-1777, Immucillin H)--a new purine nucleoside analogue: mechanism of action and potential clinical application.

Korycka A, Błoński JZ, Robak T.

Mini Rev Med Chem. 2007 Sep;7(9):976-83. Review.

PMID:
17897085
19.

Four generations of transition-state analogues for human purine nucleoside phosphorylase.

Ho MC, Shi W, Rinaldo-Matthis A, Tyler PC, Evans GB, Clinch K, Almo SC, Schramm VL.

Proc Natl Acad Sci U S A. 2010 Mar 16;107(11):4805-12. doi: 10.1073/pnas.0913439107. Epub 2010 Mar 8.

20.

Mechanism of inhibition of T-acute lymphoblastic leukemia cells by PNP inhibitor--BCX-1777.

Bantia S, Ananth SL, Parker CD, Horn LL, Upshaw R.

Int Immunopharmacol. 2003 Jun;3(6):879-87.

PMID:
12781704

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