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Items: 1 to 20 of 143

1.

QSAR study of substituted 1,3,4-oxadiazole naphthyridines as HIV-1 integrase inhibitors.

Ravichandran V, Shalini S, Sundram K, Sokkalingam AD.

Eur J Med Chem. 2010 Jul;45(7):2791-7. doi: 10.1016/j.ejmech.2010.02.062. Epub 2010 Mar 7.

PMID:
20347187
2.

The use of oxadiazole and triazole substituted naphthyridines as HIV-1 integrase inhibitors. Part 1: Establishing the pharmacophore.

Johns BA, Weatherhead JG, Allen SH, Thompson JB, Garvey EP, Foster SA, Jeffrey JL, Miller WH.

Bioorg Med Chem Lett. 2009 Mar 15;19(6):1802-6. doi: 10.1016/j.bmcl.2009.01.090. Epub 2009 Jan 30.

PMID:
19217781
3.

Exploring molecular shape analysis of styrylquinoline derivatives as HIV-1 integrase inhibitors.

Leonard JT, Roy K.

Eur J Med Chem. 2008 Jan;43(1):81-92. Epub 2007 Mar 14.

PMID:
17452064
4.

1,3,4-Oxadiazole substituted naphthyridines as HIV-1 integrase inhibitors. Part 2: SAR of the C5 position.

Johns BA, Weatherhead JG, Allen SH, Thompson JB, Garvey EP, Foster SA, Jeffrey JL, Miller WH.

Bioorg Med Chem Lett. 2009 Mar 15;19(6):1807-10. doi: 10.1016/j.bmcl.2009.01.089. Epub 2009 Jan 30.

PMID:
19217284
5.

QSAR study of carboxylic acid derivatives as HIV-1 Integrase inhibitors.

Cheng Z, Zhang Y, Fu W.

Eur J Med Chem. 2010 Sep;45(9):3970-80. doi: 10.1016/j.ejmech.2010.05.052. Epub 2010 Jun 1.

PMID:
20561721
6.

Synthesis of 5-(1-H or 1-alkyl-5-oxopyrrolidin-3-yl)-8-hydroxy-[1,6]-naphthyridine-7-carboxamide inhibitors of HIV-1 integrase.

Melamed JY, Egbertson MS, Varga S, Vacca JP, Moyer G, Gabryelski L, Felock PJ, Stillmock KA, Witmer MV, Schleif W, Hazuda DJ, Leonard Y, Jin L, Ellis JD, Young SD.

Bioorg Med Chem Lett. 2008 Oct 1;18(19):5307-10. doi: 10.1016/j.bmcl.2008.08.038. Epub 2008 Aug 14.

PMID:
18774711
7.

Computational modeling methods for QSAR studies on HIV-1 integrase inhibitors (2005-2010).

Ko GM, Reddy AS, Garg R, Kumar S, Hadaegh AR.

Curr Comput Aided Drug Des. 2012 Dec 1;8(4):255-70. Review.

PMID:
22242796
8.

CoMFA and CoMSIA 3D-QSAR studies on quionolone caroxylic acid derivatives inhibitors of HIV-1 integrase.

Lu P, Wei X, Zhang R.

Eur J Med Chem. 2010 Aug;45(8):3413-9. doi: 10.1016/j.ejmech.2010.04.030. Epub 2010 May 21.

PMID:
20488589
9.

Multivariate QSAR study of 4,5-dihydroxypyrimidine carboxamides as HIV-1 integrase inhibitors.

de Melo EB, Ferreira MM.

Eur J Med Chem. 2009 Sep;44(9):3577-83. doi: 10.1016/j.ejmech.2009.03.001. Epub 2009 Mar 9.

PMID:
19327872
10.

Investigation of the structural requirement for inhibiting HIV integrase: QSAR study.

Dessalew N.

Acta Pharm. 2009 Mar;59(1):31-43. doi: 10.2478/v10007-009-0006-y.

PMID:
19304556
11.

Synthesis and antiviral activity of 7-benzyl-4-hydroxy-1,5-naphthyridin-2(1H)-one HIV integrase inhibitors.

Boros EE, Edwards CE, Foster SA, Fuji M, Fujiwara T, Garvey EP, Golden PL, Hazen RJ, Jeffrey JL, Johns BA, Kawasuji T, Kiyama R, Koble CS, Kurose N, Miller WH, Mote AL, Murai H, Sato A, Thompson JB, Woodward MC, Yoshinaga T.

J Med Chem. 2009 May 14;52(9):2754-61. doi: 10.1021/jm801404b.

PMID:
19374386
12.

Repositioning HIV-1 integrase inhibitors for cancer therapeutics: 1,6-naphthyridine-7-carboxamide as a promising scaffold with drug-like properties.

Zeng LF, Wang Y, Kazemi R, Xu S, Xu ZL, Sanchez TW, Yang LM, Debnath B, Odde S, Xie H, Zheng YT, Ding J, Neamati N, Long YQ.

J Med Chem. 2012 Nov 26;55(22):9492-509. doi: 10.1021/jm300667v. Epub 2012 Nov 7.

PMID:
23098137
13.

QSAR studies of HIV-1 integrase inhibition.

Yuan H, Parrill AL.

Bioorg Med Chem. 2002 Dec;10(12):4169-83.

PMID:
12413870
14.

Treating chemical diversity in QSAR analysis: modeling diverse HIV-1 integrase inhibitors using 4D fingerprints.

Iyer M, Hopfinger AJ.

J Chem Inf Model. 2007 Sep-Oct;47(5):1945-60. Epub 2007 Jul 28.

PMID:
17661457
15.

A series of 5-aminosubstituted 4-fluorobenzyl-8-hydroxy-[1,6]naphthyridine-7-carboxamide HIV-1 integrase inhibitors.

Guare JP, Wai JS, Gomez RP, Anthony NJ, Jolly SM, Cortes AR, Vacca JP, Felock PJ, Stillmock KA, Schleif WA, Moyer G, Gabryelski LJ, Jin L, Chen IW, Hazuda DJ, Young SD.

Bioorg Med Chem Lett. 2006 Jun 1;16(11):2900-4. Epub 2006 Mar 22.

PMID:
16554152
16.

A novel QSAR model for predicting the inhibition of CXCR3 receptor by 4-N-aryl-[1,4] diazepane ureas.

Afantitis A, Melagraki G, Sarimveis H, Igglessi-Markopoulou O, Kollias G.

Eur J Med Chem. 2009 Feb;44(2):877-84. doi: 10.1016/j.ejmech.2008.05.028. Epub 2008 Jul 10.

PMID:
18619714
17.

3D-QSAR studies of quinoline ring derivatives as HIV-1 integrase inhibitors.

Sun XH, Guan JQ, Tan JJ, Liu C, Wang CX.

SAR QSAR Environ Res. 2012 Oct;23(7-8):683-703. doi: 10.1080/1062936X.2012.717541. Epub 2012 Sep 20.

PMID:
22991976
18.
19.
20.

Design and synthesis of 8-hydroxy-[1,6]naphthyridines as novel inhibitors of HIV-1 integrase in vitro and in infected cells.

Zhuang L, Wai JS, Embrey MW, Fisher TE, Egbertson MS, Payne LS, Guare JP Jr, Vacca JP, Hazuda DJ, Felock PJ, Wolfe AL, Stillmock KA, Witmer MV, Moyer G, Schleif WA, Gabryelski LJ, Leonard YM, Lynch JJ Jr, Michelson SR, Young SD.

J Med Chem. 2003 Feb 13;46(4):453-6.

PMID:
12570367

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