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Items: 1 to 20 of 100

1.

Protein kinase C-theta mediates negative feedback on regulatory T cell function.

Zanin-Zhorov A, Ding Y, Kumari S, Attur M, Hippen KL, Brown M, Blazar BR, Abramson SB, Lafaille JJ, Dustin ML.

Science. 2010 Apr 16;328(5976):372-6. doi: 10.1126/science.1186068. Epub 2010 Mar 25. Erratum in: Science. 2010 May 21;328(5981):974.

2.

In and out of the bull's eye: protein kinase Cs in the immunological synapse.

Kong KF, Altman A.

Trends Immunol. 2013 May;34(5):234-42. doi: 10.1016/j.it.2013.01.002. Epub 2013 Feb 19. Review.

3.

PKC-θ function at the immunological synapse: prospects for therapeutic targeting.

Zanin-Zhorov A, Dustin ML, Blazar BR.

Trends Immunol. 2011 Aug;32(8):358-63. doi: 10.1016/j.it.2011.04.007. Epub 2011 Jul 4. Review.

4.

Differential requirement of PKC-theta in the development and function of natural regulatory T cells.

Gupta S, Manicassamy S, Vasu C, Kumar A, Shang W, Sun Z.

Mol Immunol. 2008 Dec;46(2):213-24. doi: 10.1016/j.molimm.2008.08.275. Epub 2008 Oct 8.

5.

A motif in the V3 domain of the kinase PKC-θ determines its localization in the immunological synapse and functions in T cells via association with CD28.

Kong KF, Yokosuka T, Canonigo-Balancio AJ, Isakov N, Saito T, Altman A.

Nat Immunol. 2011 Oct 2;12(11):1105-12. doi: 10.1038/ni.2120.

6.

Embryonic stem cell-derived factors inhibit T effector activation and induce T regulatory cells by suppressing PKC-θ activation.

Mohib K, AlKhamees B, Zein HS, Allan D, Wang L.

PLoS One. 2012;7(3):e32420. doi: 10.1371/journal.pone.0032420. Epub 2012 Mar 7.

7.

TCR-induced sumoylation of the kinase PKC-θ controls T cell synapse organization and T cell activation.

Wang XD, Gong Y, Chen ZL, Gong BN, Xie JJ, Zhong CQ, Wang QL, Diao LH, Xu A, Han J, Altman A, Li Y.

Nat Immunol. 2015 Nov;16(11):1195-203. doi: 10.1038/ni.3259. Epub 2015 Sep 21.

PMID:
26390157
8.

Protein kinase C theta is critical for the development of in vivo T helper (Th)2 cell but not Th1 cell responses.

Marsland BJ, Soos TJ, Späth G, Littman DR, Kopf M.

J Exp Med. 2004 Jul 19;200(2):181-9.

9.

TCR signalling network organization at the immunological synapses of murine regulatory T cells.

van Ham M, Teich R, Philipsen L, Niemz J, Amsberg N, Wissing J, Nimtz M, Gröbe L, Kliche S, Thiel N, Klawonn F, Hubo M, Jonuleit H, Reichardt P, Müller AJ, Huehn J, Jänsch L.

Eur J Immunol. 2017 Dec;47(12):2043-2058. doi: 10.1002/eji.201747041. Epub 2017 Sep 12.

PMID:
28833060
10.

Protein kinase C-θ inhibits inducible regulatory T cell differentiation via an AKT-Foxo1/3a-dependent pathway.

Ma J, Ding Y, Fang X, Wang R, Sun Z.

J Immunol. 2012 Jun 1;188(11):5337-47. doi: 10.4049/jimmunol.1102979. Epub 2012 Apr 25.

11.

Phenotypic, Functional, and Gene Expression Profiling of Peripheral CD45RA+ and CD45RO+ CD4+CD25+CD127(low) Treg Cells in Patients With Chronic Rheumatoid Arthritis.

Walter GJ, Fleskens V, Frederiksen KS, Rajasekhar M, Menon B, Gerwien JG, Evans HG, Taams LS.

Arthritis Rheumatol. 2016 Jan;68(1):103-16. doi: 10.1002/art.39408.

12.

Inhibiting the inhibitor of the inhibitor: blocking PKC-theta to enhance regulatory T cell function.

Roybal KT, Wülfing C.

Sci Signal. 2010 Jul 27;3(132):pe24. doi: 10.1126/scisignal.3132pe24.

PMID:
20664063
13.

Extracellular purine metabolism and signaling of CD73-derived adenosine in murine Treg and Teff cells.

Romio M, Reinbeck B, Bongardt S, Hüls S, Burghoff S, Schrader J.

Am J Physiol Cell Physiol. 2011 Aug;301(2):C530-9. doi: 10.1152/ajpcell.00385.2010. Epub 2011 May 18.

14.

PKC-theta is required for TCR-induced NF-kappaB activation in mature but not immature T lymphocytes.

Sun Z, Arendt CW, Ellmeier W, Schaeffer EM, Sunshine MJ, Gandhi L, Annes J, Petrzilka D, Kupfer A, Schwartzberg PL, Littman DR.

Nature. 2000 Mar 23;404(6776):402-7.

PMID:
10746729
15.

CD28 plays a critical role in the segregation of PKC theta within the immunologic synapse.

Huang J, Lo PF, Zal T, Gascoigne NR, Smith BA, Levin SD, Grey HM.

Proc Natl Acad Sci U S A. 2002 Jul 9;99(14):9369-73. Epub 2002 Jun 20.

16.

Protein kinase C-η controls CTLA-4-mediated regulatory T cell function.

Kong KF, Fu G, Zhang Y, Yokosuka T, Casas J, Canonigo-Balancio AJ, Becart S, Kim G, Yates JR 3rd, Kronenberg M, Saito T, Gascoigne NR, Altman A.

Nat Immunol. 2014 May;15(5):465-72. doi: 10.1038/ni.2866. Epub 2014 Apr 6.

17.

Mice deficient in PKC theta demonstrate impaired in vivo T cell activation and protection from T cell-mediated inflammatory diseases.

Anderson K, Fitzgerald M, Dupont M, Wang T, Paz N, Dorsch M, Healy A, Xu Y, Ocain T, Schopf L, Jaffee B, Picarella D.

Autoimmunity. 2006 Sep;39(6):469-78.

PMID:
17060026
18.

T-cell fate and function: PKC-theta and beyond.

Marsland BJ, Kopf M.

Trends Immunol. 2008 Apr;29(4):179-85. doi: 10.1016/j.it.2008.01.005. Epub 2008 Mar 6. Review.

PMID:
18328786
19.

The kinase GLK controls autoimmunity and NF-κB signaling by activating the kinase PKC-θ in T cells.

Chuang HC, Lan JL, Chen DY, Yang CY, Chen YM, Li JP, Huang CY, Liu PE, Wang X, Tan TH.

Nat Immunol. 2011 Oct 9;12(11):1113-8. doi: 10.1038/ni.2121.

PMID:
21983831
20.

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