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Items: 1 to 20 of 113

1.

N-((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)arylamide as a new scaffold that provides rapid access to antimicrotubule agents: synthesis and evaluation of antiproliferative activity against select cancer cell lines.

Stefely JA, Palchaudhuri R, Miller PA, Peterson RJ, Moraski GC, Hergenrother PJ, Miller MJ.

J Med Chem. 2010 Apr 22;53(8):3389-95. doi: 10.1021/jm1000979.

2.

Synthesis and evaluation of N-((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)nicotinamides as potential anticancer agents that inhibit tubulin polymerization.

Kamal A, Reddy NV, Nayak VL, Bolla NR, Subba Rao AV, Prasad B.

Bioorg Med Chem. 2014 Jul 1;22(13):3465-77. doi: 10.1016/j.bmc.2014.04.038. Epub 2014 Apr 28.

PMID:
24835786
3.

(Z)-1-aryl-3-arylamino-2-propen-1-ones, highly active stimulators of tubulin polymerization: synthesis, structure-activity relationship (SAR), tubulin polymerization, and cell growth inhibition studies.

Reddy MV, Akula B, Cosenza SC, Lee CM, Mallireddigari MR, Pallela VR, Subbaiah DR, Udofa A, Reddy EP.

J Med Chem. 2012 Jun 14;55(11):5174-87. doi: 10.1021/jm300176j. Epub 2012 May 25.

4.

Synthesis and biological evaluation of 2,4,5-substituted pyrimidines as a new class of tubulin polymerization inhibitors.

Xie F, Zhao H, Li D, Chen H, Quan H, Shi X, Lou L, Hu Y.

J Med Chem. 2011 May 12;54(9):3200-5. doi: 10.1021/jm101388d. Epub 2011 Apr 11.

PMID:
21480626
5.

10-(2-oxo-2-phenylethylidene)-10H-anthracen-9-ones as highly active antimicrotubule agents: synthesis, antiproliferative activity, and inhibition of tubulin polymerization.

Prinz H, Schmidt P, Böhm KJ, Baasner S, Müller K, Unger E, Gerlach M, Günther EG.

J Med Chem. 2009 Mar 12;52(5):1284-94. doi: 10.1021/jm801338r.

PMID:
19220018
6.

Synthesis and in vitro pharmacological evaluation of N-[(1-benzyl-1,2,3-triazol-4-yl)methyl]-carboxamides on d-secoestrone scaffolds.

Szabó J, Bacsa I, Wölfling J, Schneider G, Zupkó I, Varga M, Herman BE, Kalmár L, Szécsi M, Mernyák E.

J Enzyme Inhib Med Chem. 2016 Aug;31(4):574-9. doi: 10.3109/14756366.2015.1050008. Epub 2015 Sep 11.

PMID:
26360618
7.

Synthesis and Biochemical Evaluation of 3-Phenoxy-1,4-diarylazetidin-2-ones as Tubulin-Targeting Antitumor Agents.

Greene TF, Wang S, Greene LM, Nathwani SM, Pollock JK, Malebari AM, McCabe T, Twamley B, O'Boyle NM, Zisterer DM, Meegan MJ.

J Med Chem. 2016 Jan 14;59(1):90-113. doi: 10.1021/acs.jmedchem.5b01086. Epub 2015 Dec 17.

PMID:
26680364
8.

Synthesis and biological evaluation of 1,2,3-triazole linked aminocombretastatin conjugates as mitochondrial mediated apoptosis inducers.

Kamal A, Shaik B, Nayak VL, Nagaraju B, Kapure JS, Shaheer Malik M, Shaik TB, Prasad B.

Bioorg Med Chem. 2014 Oct 1;22(19):5155-67. doi: 10.1016/j.bmc.2014.08.008. Epub 2014 Aug 19.

PMID:
25192811
9.

Synthesis and antitumor activity of 1,5-disubstituted 1,2,4-triazoles as cis-restricted combretastatin analogues.

Romagnoli R, Baraldi PG, Cruz-Lopez O, Lopez Cara C, Carrion MD, Brancale A, Hamel E, Chen L, Bortolozzi R, Basso G, Viola G.

J Med Chem. 2010 May 27;53(10):4248-58. doi: 10.1021/jm100245q.

10.

Synthesis, biological evaluation and molecular docking studies of trans-indole-3-acrylamide derivatives, a new class of tubulin polymerization inhibitors.

Baytas SN, Inceler N, Yilmaz A, Olgac A, Menevse S, Banoglu E, Hamel E, Bortolozzi R, Viola G.

Bioorg Med Chem. 2014 Jun 15;22(12):3096-104. doi: 10.1016/j.bmc.2014.04.027. Epub 2014 Apr 20.

11.

Discovery of novel 2-N-aryl-substituted benzenesulfonamidoacetamides: orally bioavailable tubulin polymerization inhibitors with marked antitumor activities.

Liu Z, Zhou Z, Tian W, Fan X, Xue D, Yu L, Yu Q, Long YQ.

ChemMedChem. 2012 Apr;7(4):680-93. doi: 10.1002/cmdc.201100529. Epub 2012 Feb 6.

PMID:
22311585
12.

Design, synthesis, and biological evaluation of thiophene analogues of chalcones.

Romagnoli R, Baraldi PG, Carrion MD, Cara CL, Cruz-Lopez O, Preti D, Tolomeo M, Grimaudo S, Di Cristina A, Zonta N, Balzarini J, Brancale A, Sarkar T, Hamel E.

Bioorg Med Chem. 2008 May 15;16(10):5367-76. doi: 10.1016/j.bmc.2008.04.026. Epub 2008 Apr 15.

PMID:
18440234
13.

Synthesis and SAR of C12-C13-oxazoline derivatives of epothilone A.

Pfeiffer B, Hauenstein K, Merz P, Gertsch J, Altmann KH.

Bioorg Med Chem Lett. 2009 Jul 15;19(14):3760-3. doi: 10.1016/j.bmcl.2009.04.112. Epub 2009 May 3.

PMID:
19433359
14.

Discovery of potent cytotoxic ortho-aryl chalcones as new scaffold targeting tubulin and mitosis with affinity-based fluorescence.

Zhu C, Zuo Y, Wang R, Liang B, Yue X, Wen G, Shang N, Huang L, Chen Y, Du J, Bu X.

J Med Chem. 2014 Aug 14;57(15):6364-82. doi: 10.1021/jm500024v. Epub 2014 Jul 25.

PMID:
25061803
15.

Synthesis and structure-activity relationships of 1,2,4-triazoles as a novel class of potent tubulin polymerization inhibitors.

Ouyang X, Chen X, Piatnitski EL, Kiselyov AS, He HY, Mao Y, Pattaropong V, Yu Y, Kim KH, Kincaid J, Smith L 2nd, Wong WC, Lee SP, Milligan DL, Malikzay A, Fleming J, Gerlak J, Deevi D, Doody JF, Chiang HH, Patel SN, Wang Y, Rolser RL, Kussie P, Labelle M, Tuma MC.

Bioorg Med Chem Lett. 2005 Dec 1;15(23):5154-9. Epub 2005 Sep 28.

PMID:
16198562
16.

Sulfonate derivatives of naphtho[2,3-b]thiophen-4(9H)-one and 9(10H)-anthracenone as highly active antimicrotubule agents. Synthesis, antiproliferative activity, and inhibition of tubulin polymerization.

Zuse A, Schmidt P, Baasner S, Böhm KJ, Müller K, Gerlach M, Günther EG, Unger E, Prinz H.

J Med Chem. 2007 Nov 29;50(24):6059-66. Epub 2007 Oct 31.

PMID:
17973361
17.

Design, synthesis, biological evaluation and molecular modeling of 1,3,4-oxadiazoline analogs of combretastatin-A4 as novel antitubulin agents.

Hu Y, Lu X, Chen K, Yan R, Li QS, Zhu HL.

Bioorg Med Chem. 2012 Jan 15;20(2):903-9. doi: 10.1016/j.bmc.2011.11.057. Epub 2011 Dec 3.

PMID:
22192936
18.

Synthesis, biological evaluation and molecular modeling of 1,2,3-triazole analogs of combretastatin A-1.

Akselsen OW, Odlo K, Cheng JJ, Maccari G, Botta M, Hansen TV.

Bioorg Med Chem. 2012 Jan 1;20(1):234-42. doi: 10.1016/j.bmc.2011.11.010. Epub 2011 Nov 12.

PMID:
22137934
19.

Synthesis and biological evaluation of 4-aza-2,3-dihydropyridophenanthrolines as tubulin polymerization inhibitors.

Kamal A, Srinivasa Reddy T, Polepalli S, Paidakula S, Srinivasulu V, Ganga Reddy V, Jain N, Shankaraiah N.

Bioorg Med Chem Lett. 2014 Aug 1;24(15):3356-60. doi: 10.1016/j.bmcl.2014.05.096. Epub 2014 Jun 6.

PMID:
24953821
20.

Novel microtubule polymerization inhibitor with potent antiproliferative and antitumor activity.

Arora S, Wang XI, Keenan SM, Andaya C, Zhang Q, Peng Y, Welsh WJ.

Cancer Res. 2009 Mar 1;69(5):1910-5. doi: 10.1158/0008-5472.CAN-08-0877. Epub 2009 Feb 17.

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