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Items: 1 to 20 of 95

1.

Inactivation of p53 signaling by p73 or PTEN ablation results in a transformed phenotype that remains susceptible to Nutlin-3 mediated apoptosis.

Cipriano R, Patton JT, Mayo LD, Jackson MW.

Cell Cycle. 2010 Apr 1;9(7):1373-9. Epub 2010 Apr 1.

PMID:
20305378
2.

Mdm2 inhibition induces apoptosis in p53 deficient human colon cancer cells by activating p73- and E2F1-mediated expression of PUMA and Siva-1.

Ray RM, Bhattacharya S, Johnson LR.

Apoptosis. 2011 Jan;16(1):35-44. doi: 10.1007/s10495-010-0538-0.

PMID:
20812030
3.

MDM2 antagonist can inhibit tumor growth in hepatocellular carcinoma with different types of p53 in vitro.

Wang J, Zheng T, Chen X, Song X, Meng X, Bhatta N, Pan S, Jiang H, Liu L.

J Gastroenterol Hepatol. 2011 Feb;26(2):371-7. doi: 10.1111/j.1440-1746.2010.06440.x.

PMID:
21261729
4.

HDM2 antagonist Nutlin-3 disrupts p73-HDM2 binding and enhances p73 function.

Lau LM, Nugent JK, Zhao X, Irwin MS.

Oncogene. 2008 Feb 7;27(7):997-1003. Epub 2007 Aug 13.

PMID:
17700533
5.

Disruption of p73-MDM2 binding synergizes with gemcitabine to induce apoptosis in HuCCT1 cholangiocarcinoma cell line with p53 mutation.

Zheng T, Wang J, Chen X, Meng X, Song X, Lu Z, Jiang H, Liu L.

Tumour Biol. 2010 Aug;31(4):287-95. doi: 10.1007/s13277-010-0035-7. Epub 2010 Apr 27.

PMID:
20422343
6.

Mouse double minute antagonist Nutlin-3a enhances chemotherapy-induced apoptosis in cancer cells with mutant p53 by activating E2F1.

Ambrosini G, Sambol EB, Carvajal D, Vassilev LT, Singer S, Schwartz GK.

Oncogene. 2007 May 24;26(24):3473-81. Epub 2006 Dec 4.

PMID:
17146434
7.

Nutlin-3 cooperates with doxorubicin to induce apoptosis of human hepatocellular carcinoma cells through p53 or p73 signaling pathways.

Zheng T, Wang J, Song X, Meng X, Pan S, Jiang H, Liu L.

J Cancer Res Clin Oncol. 2010 Oct;136(10):1597-604. doi: 10.1007/s00432-010-0817-8. Epub 2010 Feb 20.

PMID:
20174822
8.

Induction of apoptotic genes by a p73-phosphatase and tensin homolog (p73-PTEN) protein complex in response to genotoxic stress.

Lehman JA, Waning DL, Batuello CN, Cipriano R, Kadakia MP, Mayo LD.

J Biol Chem. 2011 Oct 21;286(42):36631-40. doi: 10.1074/jbc.M110.217620. Epub 2011 Aug 26.

9.

Much ado about Nutlin.

Teoh NC.

J Gastroenterol Hepatol. 2011 Feb;26(2):213-5. doi: 10.1111/j.1440-1746.2010.06588.x. No abstract available.

PMID:
21261708
10.

Activation of the p53 pathway by the MDM2 inhibitor nutlin-3a overcomes BCL2 overexpression in a preclinical model of diffuse large B-cell lymphoma associated with t(14;18)(q32;q21).

Drakos E, Singh RR, Rassidakis GZ, Schlette E, Li J, Claret FX, Ford RJ Jr, Vega F, Medeiros LJ.

Leukemia. 2011 May;25(5):856-67. doi: 10.1038/leu.2011.28. Epub 2011 Mar 11.

11.

Combination of nutlin-3 and VX-680 selectively targets p53 mutant cells with reversible effects on cells expressing wild-type p53.

Cheok CF, Kua N, Kaldis P, Lane DP.

Cell Death Differ. 2010 Sep;17(9):1486-500. doi: 10.1038/cdd.2010.18. Epub 2010 Mar 5.

12.
13.

Functional interplay between MDM2, p63/p73 and mutant p53.

Stindt MH, Muller PA, Ludwig RL, Kehrloesser S, Dötsch V, Vousden KH.

Oncogene. 2015 Aug 13;34(33):4300-10. doi: 10.1038/onc.2014.359. Epub 2014 Nov 24.

14.

MDM2 antagonist nutlin-3 displays antiproliferative and proapoptotic activity in mantle cell lymphoma.

Tabe Y, Sebasigari D, Jin L, Rudelius M, Davies-Hill T, Miyake K, Miida T, Pittaluga S, Raffeld M.

Clin Cancer Res. 2009 Feb 1;15(3):933-42. doi: 10.1158/1078-0432.CCR-08-0399.

15.

E2F-1 transcriptional activity is a critical determinant of Mdm2 antagonist-induced apoptosis in human tumor cell lines.

Kitagawa M, Aonuma M, Lee SH, Fukutake S, McCormick F.

Oncogene. 2008 Sep 11;27(40):5303-14. doi: 10.1038/onc.2008.164. Epub 2008 Jun 2.

PMID:
18521084
16.

P53 family: at the crossroads in cancer therapy.

Alsafadi S, Tourpin S, André F, Vassal G, Ahomadegbe JC.

Curr Med Chem. 2009;16(32):4328-44. Review.

PMID:
19754415
17.

Studying p53 family proteins in yeast: induction of autophagic cell death and modulation by interactors and small molecules.

Leão M, Gomes S, Bessa C, Soares J, Raimundo L, Monti P, Fronza G, Pereira C, Saraiva L.

Exp Cell Res. 2015 Jan 1;330(1):164-77. doi: 10.1016/j.yexcr.2014.09.028. Epub 2014 Sep 28.

PMID:
25265062
18.

Syntaxin 6, a regulator of the protein trafficking machinery and a target of the p53 family, is required for cell adhesion and survival.

Zhang Y, Shu L, Chen X.

J Biol Chem. 2008 Nov 7;283(45):30689-98. doi: 10.1074/jbc.M801711200. Epub 2008 Sep 8.

19.

Nutlin-3 overcomes arsenic trioxide resistance and tumor metastasis mediated by mutant p53 in Hepatocellular Carcinoma.

Zheng T, Yin D, Lu Z, Wang J, Li Y, Chen X, Liang Y, Song X, Qi S, Sun B, Xie C, Meng X, Pan S, Liu J, Jiang H, Liu L.

Mol Cancer. 2014 May 31;13:133. doi: 10.1186/1476-4598-13-133.

20.

Targeting of p53 and its homolog p73 by protoporphyrin IX.

Sznarkowska A, Maleńczyk K, Kadziński L, Bielawski KP, Banecki B, Zawacka-Pankau J.

FEBS Lett. 2011 Jan 3;585(1):255-60. doi: 10.1016/j.febslet.2010.12.004. Epub 2010 Dec 10.

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