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A small interfering RNA screen of genes involved in DNA repair identifies tumor-specific radiosensitization by POLQ knockdown.

Higgins GS, Prevo R, Lee YF, Helleday T, Muschel RJ, Taylor S, Yoshimura M, Hickson ID, Bernhard EJ, McKenna WG.

Cancer Res. 2010 Apr 1;70(7):2984-93. doi: 10.1158/0008-5472.CAN-09-4040. Erratum in: Cancer Res. 2010 May 1;70(9):3853.


A comprehensive analysis of radiosensitization targets; functional inhibition of DNA methyltransferase 3B radiosensitizes by disrupting DNA damage regulation.

Fujimori H, Sato A, Kikuhara S, Wang J, Hirai T, Sasaki Y, Murakami Y, Okayasu R, Masutani M.

Sci Rep. 2015 Dec 15;5:18231. doi: 10.1038/srep18231.


Rad51 inhibition is an effective means of targeting DNA repair in glioma models and CD133+ tumor-derived cells.

Short SC, Giampieri S, Worku M, Alcaide-German M, Sioftanos G, Bourne S, Lio KI, Shaked-Rabi M, Martindale C.

Neuro Oncol. 2011 May;13(5):487-99. doi: 10.1093/neuonc/nor010.


Lack of DNA polymerase theta (POLQ) radiosensitizes bone marrow stromal cells in vitro and increases reticulocyte micronuclei after total-body irradiation.

Goff JP, Shields DS, Seki M, Choi S, Epperly MW, Dixon T, Wang H, Bakkenist CJ, Dertinger SD, Torous DK, Wittschieben J, Wood RD, Greenberger JS.

Radiat Res. 2009 Aug;172(2):165-74. doi: 10.1667/RR1598.1.


Translation initiation factor eIF4E is a target for tumor cell radiosensitization.

Hayman TJ, Williams ES, Jamal M, Shankavaram UT, Camphausen K, Tofilon PJ.

Cancer Res. 2012 May 1;72(9):2362-72. doi: 10.1158/0008-5472.CAN-12-0329.


Inhibition of Hsp27 radiosensitizes head-and-neck cancer by modulating deoxyribonucleic acid repair.

Guttmann DM, Hart L, Du K, Seletsky A, Koumenis C.

Int J Radiat Oncol Biol Phys. 2013 Sep 1;87(1):168-75. doi: 10.1016/j.ijrobp.2013.05.028.


Knocking Down Nucleolin Expression Enhances the Radiosensitivity of Non-Small Cell Lung Cancer by Influencing DNA-PKcs Activity.

Xu JY, Lu S, Xu XY, Hu SL, Li B, Qi RX, Chen L, Chang JY.

Asian Pac J Cancer Prev. 2015;16(8):3301-6.


Identification of vitamin B1 metabolism as a tumor-specific radiosensitizing pathway using a high-throughput colony formation screen.

Tiwana GS, Prevo R, Buffa FM, Yu S, Ebner DV, Howarth A, Folkes LK, Budwal B, Chu KY, Durrant L, Muschel RJ, McKenna WG, Higgins GS.

Oncotarget. 2015 Mar 20;6(8):5978-89.


Early increase of radiation-induced γH2AX foci in a human Ku70/80 knockdown cell line characterized by an enhanced radiosensitivity.

Vandersickel V, Depuydt J, Van Bockstaele B, Perletti G, Philippe J, Thierens H, Vral A.

J Radiat Res. 2010;51(6):633-41.


Down regulation of BRCA2 causes radio-sensitization of human tumor cells in vitro and in vivo.

Yu D, Sekine E, Fujimori A, Ochiya T, Okayasu R.

Cancer Sci. 2008 Apr;99(4):810-5. doi: 10.1111/j.1349-7006.2008.00741.x.


Downregulation of MDC1 and 53BP1 by short hairpin RNA enhances radiosensitivity in laryngeal carcinoma cells.

Gou Q, Xie Y, Liu L, Xie K, Wu Y, Wang Q, Wang Z, Li P.

Oncol Rep. 2015 Jul;34(1):251-7. doi: 10.3892/or.2015.3980.


The SMAC mimetic BV6 sensitizes colorectal cancer cells to ionizing radiation by interfering with DNA repair processes and enhancing apoptosis.

Hehlgans S, Oppermann J, Reichert S, Fulda S, Rödel C, Rödel F.

Radiat Oncol. 2015 Sep 17;10:198. doi: 10.1186/s13014-015-0507-4.


ASPM influences DNA double-strand break repair and represents a potential target for radiotherapy.

Kato TA, Okayasu R, Jeggo PA, Fujimori A.

Int J Radiat Biol. 2011 Dec;87(12):1189-95. doi: 10.3109/09553002.2011.624152.


Histone H2AX phosphorylation as a predictor of radiosensitivity and target for radiotherapy.

Taneja N, Davis M, Choy JS, Beckett MA, Singh R, Kron SJ, Weichselbaum RR.

J Biol Chem. 2004 Jan 16;279(3):2273-80.


A novel radioresistant mechanism of galectin-1 mediated by H-Ras-dependent pathways in cervical cancer cells.

Huang EY, Chen YF, Chen YM, Lin IH, Wang CC, Su WH, Chuang PC, Yang KD.

Cell Death Dis. 2012 Jan 12;3:e251. doi: 10.1038/cddis.2011.120.


Knockdown of secreted protein acidic and rich in cysteine (SPARC) expression diminishes radiosensitivity of glioma cells.

Liu H, Zhang H, Jiang X, Ma Y, Xu Y, Feng S, Liu F.

Cancer Biother Radiopharm. 2011 Dec;26(6):705-15. doi: 10.1089/cbr.2011.0987.


APE1/REF-1 down-regulation enhances the cytotoxic effects of temozolomide in a resistant glioblastoma cell line.

Montaldi AP, Godoy PR, Sakamoto-Hojo ET.

Mutat Res Genet Toxicol Environ Mutagen. 2015 Nov;793:19-29. doi: 10.1016/j.mrgentox.2015.06.001.


Targeted radiosensitization of cells expressing truncated DNA polymerase {beta}.

Neijenhuis S, Verwijs-Janssen M, van den Broek LJ, Begg AC, Vens C.

Cancer Res. 2010 Nov 1;70(21):8706-14. doi: 10.1158/0008-5472.CAN-09-3901.


The Fanconi anemia (FA) pathway confers glioma resistance to DNA alkylating agents.

Chen CC, Taniguchi T, D'Andrea A.

J Mol Med (Berl). 2007 May;85(5):497-509.

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