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Items: 1 to 20 of 110

1.

Fumarase: a mitochondrial metabolic enzyme and a cytosolic/nuclear component of the DNA damage response.

Yogev O, Yogev O, Singer E, Shaulian E, Goldberg M, Fox TD, Pines O.

PLoS Biol. 2010 Mar 9;8(3):e1000328. doi: 10.1371/journal.pbio.1000328.

2.

Cells lacking the fumarase tumor suppressor are protected from apoptosis through a hypoxia-inducible factor-independent, AMPK-dependent mechanism.

Bardella C, Olivero M, Lorenzato A, Geuna M, Adam J, O'Flaherty L, Rustin P, Tomlinson I, Pollard PJ, Di Renzo MF.

Mol Cell Biol. 2012 Aug;32(15):3081-94. doi: 10.1128/MCB.06160-11. Epub 2012 May 29.

3.

HIF overexpression correlates with biallelic loss of fumarate hydratase in renal cancer: novel role of fumarate in regulation of HIF stability.

Isaacs JS, Jung YJ, Mole DR, Lee S, Torres-Cabala C, Chung YL, Merino M, Trepel J, Zbar B, Toro J, Ratcliffe PJ, Linehan WM, Neckers L.

Cancer Cell. 2005 Aug;8(2):143-53.

4.

Fumarate hydratase inactivation in renal tumors: HIF1α, NRF2, and "cryptic targets" of transcription factors.

Ooi A, Furge KA.

Chin J Cancer. 2012 Sep;31(9):413-20. doi: 10.5732/cjc.012.10102. Epub 2012 Jul 2. Review.

5.

Haem oxygenase is synthetically lethal with the tumour suppressor fumarate hydratase.

Frezza C, Zheng L, Folger O, Rajagopalan KN, MacKenzie ED, Jerby L, Micaroni M, Chaneton B, Adam J, Hedley A, Kalna G, Tomlinson IP, Pollard PJ, Watson DG, Deberardinis RJ, Shlomi T, Ruppin E, Gottlieb E.

Nature. 2011 Aug 17;477(7363):225-8. doi: 10.1038/nature10363.

PMID:
21849978
6.
8.

Mitochondrial and cytosolic isoforms of yeast fumarase are derivatives of a single translation product and have identical amino termini.

Sass E, Blachinsky E, Karniely S, Pines O.

J Biol Chem. 2001 Dec 7;276(49):46111-7. Epub 2001 Oct 3.

9.

Fumarate hydratase deficiency in renal cancer induces glycolytic addiction and hypoxia-inducible transcription factor 1alpha stabilization by glucose-dependent generation of reactive oxygen species.

Sudarshan S, Sourbier C, Kong HS, Block K, Valera Romero VA, Yang Y, Galindo C, Mollapour M, Scroggins B, Goode N, Lee MJ, Gourlay CW, Trepel J, Linehan WM, Neckers L.

Mol Cell Biol. 2009 Aug;29(15):4080-90. doi: 10.1128/MCB.00483-09. Epub 2009 May 26.

10.

UOK 262 cell line, fumarate hydratase deficient (FH-/FH-) hereditary leiomyomatosis renal cell carcinoma: in vitro and in vivo model of an aberrant energy metabolic pathway in human cancer.

Yang Y, Valera VA, Padilla-Nash HM, Sourbier C, Vocke CD, Vira MA, Abu-Asab MS, Bratslavsky G, Tsokos M, Merino MJ, Pinto PA, Srinivasan R, Ried T, Neckers L, Linehan WM.

Cancer Genet Cytogenet. 2010 Jan 1;196(1):45-55. doi: 10.1016/j.cancergencyto.2009.08.018.

11.

Dual localization of fumarase is dependent on the integrity of the glyoxylate shunt.

Regev-Rudzki N, Battat E, Goldberg I, Pines O.

Mol Microbiol. 2009 Apr;72(2):297-306.

PMID:
19415796
12.

Modeling tumor predisposing FH mutations in yeast: effects on fumarase activity, growth phenotype and gene expression profile.

Kokko A, Ylisaukko-Oja SS, Kiuru M, Takatalo MS, Salmikangas P, Tuimala J, Arango D, Karhu A, Aaltonen LA, Jäntti J.

Int J Cancer. 2006 Mar 15;118(6):1340-5.

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15.

Genetic and functional analyses of FH mutations in multiple cutaneous and uterine leiomyomatosis, hereditary leiomyomatosis and renal cancer, and fumarate hydratase deficiency.

Alam NA, Rowan AJ, Wortham NC, Pollard PJ, Mitchell M, Tyrer JP, Barclay E, Calonje E, Manek S, Adams SJ, Bowers PW, Burrows NP, Charles-Holmes R, Cook LJ, Daly BM, Ford GP, Fuller LC, Hadfield-Jones SE, Hardwick N, Highet AS, Keefe M, MacDonald-Hull SP, Potts ED, Crone M, Wilkinson S, Camacho-Martinez F, Jablonska S, Ratnavel R, MacDonald A, Mann RJ, Grice K, Guillet G, Lewis-Jones MS, McGrath H, Seukeran DC, Morrison PJ, Fleming S, Rahman S, Kelsell D, Leigh I, Olpin S, Tomlinson IP.

Hum Mol Genet. 2003 Jun 1;12(11):1241-52.

PMID:
12761039
16.

LDH-A inhibition, a therapeutic strategy for treatment of hereditary leiomyomatosis and renal cell cancer.

Xie H, Valera VA, Merino MJ, Amato AM, Signoretti S, Linehan WM, Sukhatme VP, Seth P.

Mol Cancer Ther. 2009 Mar;8(3):626-35. doi: 10.1158/1535-7163.MCT-08-1049. Epub 2009 Mar 10.

17.

Fumarase: a paradigm of dual targeting and dual localized functions.

Yogev O, Naamati A, Pines O.

FEBS J. 2011 Nov;278(22):4230-42. doi: 10.1111/j.1742-4658.2011.08359.x. Epub 2011 Oct 24. Review.

18.

Expression profiling in progressive stages of fumarate-hydratase deficiency: the contribution of metabolic changes to tumorigenesis.

Ashrafian H, O'Flaherty L, Adam J, Steeples V, Chung YL, East P, Vanharanta S, Lehtonen H, Nye E, Hatipoglu E, Miranda M, Howarth K, Shukla D, Troy H, Griffiths J, Spencer-Dene B, Yusuf M, Volpi E, Maxwell PH, Stamp G, Poulsom R, Pugh CW, Costa B, Bardella C, Di Renzo MF, Kotlikoff MI, Launonen V, Aaltonen L, El-Bahrawy M, Tomlinson I, Pollard PJ.

Cancer Res. 2010 Nov 15;70(22):9153-65. doi: 10.1158/0008-5472.CAN-10-1949. Epub 2010 Oct 26.

19.

Clinical and biochemical heterogeneity associated with fumarase deficiency.

Ottolenghi C, Hubert L, Allanore Y, Brassier A, Altuzarra C, Mellot-Draznieks C, Bekri S, Goldenberg A, Veyrieres S, Boddaert N, Barbier V, Valayannopoulos V, Slama A, Chrétien D, Ricquier D, Marret S, Frebourg T, Rabier D, Munnich A, de Keyzer Y, Toulhoat H, de Lonlay P.

Hum Mutat. 2011 Sep;32(9):1046-52. doi: 10.1002/humu.21534. Epub 2011 Jul 12.

PMID:
21560188
20.

Expression and properties of the mitochondrial and cytosolic forms of fumarase in germinating maize seeds.

Eprintsev AT, Fedorin DN, Starinina EV, Igamberdiev AU.

Physiol Plant. 2014 Oct;152(2):231-40. doi: 10.1111/ppl.12181. Epub 2014 Apr 2.

PMID:
24611547

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