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Items: 1 to 20 of 159

1.

Mycobacterium tuberculosis MycP1 protease plays a dual role in regulation of ESX-1 secretion and virulence.

Ohol YM, Goetz DH, Chan K, Shiloh MU, Craik CS, Cox JS.

Cell Host Microbe. 2010 Mar 18;7(3):210-20. doi: 10.1016/j.chom.2010.02.006.

2.

Secreted transcription factor controls Mycobacterium tuberculosis virulence.

Raghavan S, Manzanillo P, Chan K, Dovey C, Cox JS.

Nature. 2008 Aug 7;454(7205):717-21. doi: 10.1038/nature07219.

3.

A mycobacterium ESX-1-secreted virulence factor with unique requirements for export.

McLaughlin B, Chon JS, MacGurn JA, Carlsson F, Cheng TL, Cox JS, Brown EJ.

PLoS Pathog. 2007 Aug 3;3(8):e105.

4.

C-terminal signal sequence promotes virulence factor secretion in Mycobacterium tuberculosis.

Champion PA, Stanley SA, Champion MM, Brown EJ, Cox JS.

Science. 2006 Sep 15;313(5793):1632-6.

5.

Understanding specificity of the mycosin proteases in ESX/type VII secretion by structural and functional analysis.

Wagner JM, Evans TJ, Chen J, Zhu H, Houben EN, Bitter W, Korotkov KV.

J Struct Biol. 2013 Nov;184(2):115-28. doi: 10.1016/j.jsb.2013.09.022. Epub 2013 Oct 7.

6.

The putative propeptide of MycP1 in mycobacterial type VII secretion system does not inhibit protease activity but improves protein stability.

Sun D, Liu Q, He Y, Wang C, Wu F, Tian C, Zang J.

Protein Cell. 2013 Dec;4(12):921-31. doi: 10.1007/s13238-013-3089-7. Epub 2013 Nov 18.

7.

Disruption of the ESX-5 system of Mycobacterium tuberculosis causes loss of PPE protein secretion, reduction of cell wall integrity and strong attenuation.

Bottai D, Di Luca M, Majlessi L, Frigui W, Simeone R, Sayes F, Bitter W, Brennan MJ, Leclerc C, Batoni G, Campa M, Brosch R, Esin S.

Mol Microbiol. 2012 Mar;83(6):1195-209. doi: 10.1111/j.1365-2958.2012.08001.x. Epub 2012 Feb 20.

8.

ESAT-6 secretion-independent impact of ESX-1 genes espF and espG1 on virulence of Mycobacterium tuberculosis.

Bottai D, Majlessi L, Simeone R, Frigui W, Laurent C, Lenormand P, Chen J, Rosenkrands I, Huerre M, Leclerc C, Cole ST, Brosch R.

J Infect Dis. 2011 Apr 15;203(8):1155-64. doi: 10.1093/infdis/jiq089. Epub 2010 Dec 31.

PMID:
21196469
9.

A unique Mycobacterium ESX-1 protein co-secretes with CFP-10/ESAT-6 and is necessary for inhibiting phagosome maturation.

Xu J, Laine O, Masciocchi M, Manoranjan J, Smith J, Du SJ, Edwards N, Zhu X, Fenselau C, Gao LY.

Mol Microbiol. 2007 Nov;66(3):787-800. Epub 2007 Oct 1.

10.

Phenotypic profiling of Mycobacterium tuberculosis EspA point mutants reveals that blockage of ESAT-6 and CFP-10 secretion in vitro does not always correlate with attenuation of virulence.

Chen JM, Zhang M, Rybniker J, Basterra L, Dhar N, Tischler AD, Pojer F, Cole ST.

J Bacteriol. 2013 Dec;195(24):5421-30. doi: 10.1128/JB.00967-13. Epub 2013 Sep 27.

11.
12.

Structure of EspB, a secreted substrate of the ESX-1 secretion system of Mycobacterium tuberculosis.

Korotkova N, Piton J, Wagner JM, Boy-Röttger S, Japaridze A, Evans TJ, Cole ST, Pojer F, Korotkov KV.

J Struct Biol. 2015 Aug;191(2):236-44. doi: 10.1016/j.jsb.2015.06.003. Epub 2015 Jun 4.

13.

A Duplicated ESAT-6 Region of ESX-5 Is Involved in Protein Export and Virulence of Mycobacteria.

Shah S, Cannon JR, Fenselau C, Briken V.

Infect Immun. 2015 Nov;83(11):4349-61. doi: 10.1128/IAI.00827-15. Epub 2015 Aug 24.

14.

A novel ESX-1 locus reveals that surface-associated ESX-1 substrates mediate virulence in Mycobacterium marinum.

Kennedy GM, Hooley GC, Champion MM, Mba Medie F, Champion PA.

J Bacteriol. 2014 May;196(10):1877-88. doi: 10.1128/JB.01502-14. Epub 2014 Mar 7.

15.

Separable roles for Mycobacterium tuberculosis ESX-3 effectors in iron acquisition and virulence.

Tufariello JM, Chapman JR, Kerantzas CA, Wong KW, Vilchèze C, Jones CM, Cole LE, Tinaztepe E, Thompson V, Fenyö D, Niederweis M, Ueberheide B, Philips JA, Jacobs WR Jr.

Proc Natl Acad Sci U S A. 2016 Jan 19;113(3):E348-57. doi: 10.1073/pnas.1523321113. Epub 2016 Jan 4.

16.

Structure of the mycosin-1 protease from the mycobacterial ESX-1 protein type VII secretion system.

Solomonson M, Huesgen PF, Wasney GA, Watanabe N, Gruninger RJ, Prehna G, Overall CM, Strynadka NC.

J Biol Chem. 2013 Jun 14;288(24):17782-90. doi: 10.1074/jbc.M113.462036. Epub 2013 Apr 25.

17.

Pentapeptide boronic acid inhibitors of Mycobacterium tuberculosis MycP1 protease.

Frasinyuk MS, Kwiatkowski S, Wagner JM, Evans TJ, Reed RW, Korotkov KV, Watt DS.

Bioorg Med Chem Lett. 2014 Aug 1;24(15):3546-8. doi: 10.1016/j.bmcl.2014.05.056. Epub 2014 May 27.

18.

ESX-1 secreted virulence factors are recognized by multiple cytosolic AAA ATPases in pathogenic mycobacteria.

Champion PA, Champion MM, Manzanillo P, Cox JS.

Mol Microbiol. 2009 Sep;73(5):950-62. doi: 10.1111/j.1365-2958.2009.06821.x. Epub 2009 Aug 4.

19.

EspR-dependent ESAT-6 Protein Secretion of Mycobacterium tuberculosis Requires the Presence of Virulence Regulator PhoP.

Anil Kumar V, Goyal R, Bansal R, Singh N, Sevalkar RR, Kumar A, Sarkar D.

J Biol Chem. 2016 Sep 2;291(36):19018-30. doi: 10.1074/jbc.M116.746289. Epub 2016 Jul 21.

20.

Mycosins of the Mycobacterial Type VII ESX Secretion System: the Glue That Holds the Party Together.

Chen JM.

MBio. 2016 Dec 13;7(6). pii: e02062-16. doi: 10.1128/mBio.02062-16.

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