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Items: 1 to 20 of 122

1.

Modularity of the Hrd1 ERAD complex underlies its diverse client range.

Kanehara K, Xie W, Ng DT.

J Cell Biol. 2010 Mar 8;188(5):707-16. doi: 10.1083/jcb.200907055.

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Intrinsic conformational determinants signal protein misfolding to the Hrd1/Htm1 endoplasmic reticulum-associated degradation system.

Xie W, Kanehara K, Sayeed A, Ng DT.

Mol Biol Cell. 2009 Jul;20(14):3317-29. doi: 10.1091/mbc.E09-03-0231. Epub 2009 May 20.

4.

Recognition of an ERAD-L substrate analyzed by site-specific in vivo photocrosslinking.

Stanley AM, Carvalho P, Rapoport T.

FEBS Lett. 2011 May 6;585(9):1281-6. doi: 10.1016/j.febslet.2011.04.009. Epub 2011 Apr 8.

5.

Usa1p is required for optimal function and regulation of the Hrd1p endoplasmic reticulum-associated degradation ubiquitin ligase.

Carroll SM, Hampton RY.

J Biol Chem. 2010 Feb 19;285(8):5146-56. doi: 10.1074/jbc.M109.067876. Epub 2009 Nov 24.

6.

Yos9p and Hrd1p mediate ER retention of misfolded proteins for ER-associated degradation.

Izawa T, Nagai H, Endo T, Nishikawa S.

Mol Biol Cell. 2012 Apr;23(7):1283-93. doi: 10.1091/mbc.E11-08-0722. Epub 2012 Feb 1.

7.

A stalled retrotranslocation complex reveals physical linkage between substrate recognition and proteasomal degradation during ER-associated degradation.

Nakatsukasa K, Brodsky JL, Kamura T.

Mol Biol Cell. 2013 Jun;24(11):1765-75, S1-8. doi: 10.1091/mbc.E12-12-0907. Epub 2013 Mar 27.

8.

Direct and essential function for Hrd3 in ER-associated degradation.

Vashistha N, Neal SE, Singh A, Carroll SM, Hampton RY.

Proc Natl Acad Sci U S A. 2016 May 24;113(21):5934-9. doi: 10.1073/pnas.1603079113. Epub 2016 May 11.

9.
10.

gp78 functions downstream of Hrd1 to promote degradation of misfolded proteins of the endoplasmic reticulum.

Zhang T, Xu Y, Liu Y, Ye Y.

Mol Biol Cell. 2015 Dec 1;26(24):4438-50. doi: 10.1091/mbc.E15-06-0354. Epub 2015 Sep 30.

11.

N-terminal acetylation of the yeast Derlin Der1 is essential for Hrd1 ubiquitin-ligase activity toward luminal ER substrates.

Zattas D, Adle DJ, Rubenstein EM, Hochstrasser M.

Mol Biol Cell. 2013 Apr;24(7):890-900. doi: 10.1091/mbc.E12-11-0838. Epub 2013 Jan 30.

12.

Derlin2 protein facilitates HRD1-mediated retro-translocation of sonic hedgehog at the endoplasmic reticulum.

Huang CH, Hsiao HT, Chu YR, Ye Y, Chen X.

J Biol Chem. 2013 Aug 30;288(35):25330-9. doi: 10.1074/jbc.M113.455212. Epub 2013 Jul 18.

13.

A Conserved C-terminal Element in the Yeast Doa10 and Human MARCH6 Ubiquitin Ligases Required for Selective Substrate Degradation.

Zattas D, Berk JM, Kreft SG, Hochstrasser M.

J Biol Chem. 2016 Jun 3;291(23):12105-18. doi: 10.1074/jbc.M116.726877. Epub 2016 Apr 11.

14.

Dfm1 forms distinct complexes with Cdc48 and the ER ubiquitin ligases and is required for ERAD.

Stolz A, Schweizer RS, Schäfer A, Wolf DH.

Traffic. 2010 Oct;11(10):1363-9. doi: 10.1111/j.1600-0854.2010.01093.x.

15.

Aberrant substrate engagement of the ER translocon triggers degradation by the Hrd1 ubiquitin ligase.

Rubenstein EM, Kreft SG, Greenblatt W, Swanson R, Hochstrasser M.

J Cell Biol. 2012 Jun 11;197(6):761-73. doi: 10.1083/jcb.201203061.

16.

A complex of Yos9p and the HRD ligase integrates endoplasmic reticulum quality control into the degradation machinery.

Gauss R, Jarosch E, Sommer T, Hirsch C.

Nat Cell Biol. 2006 Aug;8(8):849-54. Epub 2006 Jul 16.

PMID:
16845381
17.
18.

Autoubiquitination of the Hrd1 Ligase Triggers Protein Retrotranslocation in ERAD.

Baldridge RD, Rapoport TA.

Cell. 2016 Jul 14;166(2):394-407. doi: 10.1016/j.cell.2016.05.048. Epub 2016 Jun 16.

19.

Hsp70 targets a cytoplasmic quality control substrate to the San1p ubiquitin ligase.

Guerriero CJ, Weiberth KF, Brodsky JL.

J Biol Chem. 2013 Jun 21;288(25):18506-20. doi: 10.1074/jbc.M113.475905. Epub 2013 May 7.

20.

Association of the SEL1L protein transmembrane domain with HRD1 ubiquitin ligase regulates ERAD-L.

Hosokawa N, Wada I.

FEBS J. 2016 Jan;283(1):157-72. doi: 10.1111/febs.13564. Epub 2015 Nov 6.

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