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Signaling mechanisms that link salt retention to hypertension: endogenous ouabain, the Na(+) pump, the Na(+)/Ca(2+) exchanger and TRPC proteins.

Blaustein MP, Hamlyn JM.

Biochim Biophys Acta. 2010 Dec;1802(12):1219-29. doi: 10.1016/j.bbadis.2010.02.011. Epub 2010 Mar 6. Review.


Nanomolar ouabain increases NCX1 expression and enhances Ca2+ signaling in human arterial myocytes: a mechanism that links salt to increased vascular resistance?

Linde CI, Antos LK, Golovina VA, Blaustein MP.

Am J Physiol Heart Circ Physiol. 2012 Oct 1;303(7):H784-94. doi: 10.1152/ajpheart.00399.2012. Epub 2012 Jul 27.


Activation of c-SRC underlies the differential effects of ouabain and digoxin on Ca(2+) signaling in arterial smooth muscle cells.

Zulian A, Linde CI, Pulina MV, Baryshnikov SG, Papparella I, Hamlyn JM, Golovina VA.

Am J Physiol Cell Physiol. 2013 Feb 15;304(4):C324-33. doi: 10.1152/ajpcell.00337.2012. Epub 2012 Nov 28.


How does salt retention raise blood pressure?

Blaustein MP, Zhang J, Chen L, Hamilton BP.

Am J Physiol Regul Integr Comp Physiol. 2006 Mar;290(3):R514-23. Review.


Cross talk between plasma membrane Na(+)/Ca (2+) exchanger-1 and TRPC/Orai-containing channels: key players in arterial hypertension.

Pulina MV, Zulian A, Baryshnikov SG, Linde CI, Karashima E, Hamlyn JM, Ferrari P, Blaustein MP, Golovina VA.

Adv Exp Med Biol. 2013;961:365-74. doi: 10.1007/978-1-4614-4756-6_31.


Upregulation of Na+ and Ca2+ transporters in arterial smooth muscle from ouabain-induced hypertensive rats.

Pulina MV, Zulian A, Berra-Romani R, Beskina O, Mazzocco-Spezzia A, Baryshnikov SG, Papparella I, Hamlyn JM, Blaustein MP, Golovina VA.

Am J Physiol Heart Circ Physiol. 2010 Jan;298(1):H263-74. doi: 10.1152/ajpheart.00784.2009. Epub 2009 Nov 6.


Upregulation of Na+/Ca2+ exchanger and TRPC6 contributes to abnormal Ca2+ homeostasis in arterial smooth muscle cells from Milan hypertensive rats.

Zulian A, Baryshnikov SG, Linde CI, Hamlyn JM, Ferrari P, Golovina VA.

Am J Physiol Heart Circ Physiol. 2010 Sep;299(3):H624-33. doi: 10.1152/ajpheart.00356.2010. Epub 2010 Jul 9.


How NaCl raises blood pressure: a new paradigm for the pathogenesis of salt-dependent hypertension.

Blaustein MP, Leenen FH, Chen L, Golovina VA, Hamlyn JM, Pallone TL, Van Huysse JW, Zhang J, Wier WG.

Am J Physiol Heart Circ Physiol. 2012 Mar 1;302(5):H1031-49. doi: 10.1152/ajpheart.00899.2011. Epub 2011 Nov 4. Review.


Endogenous and exogenous cardiac glycosides: their roles in hypertension, salt metabolism, and cell growth.

Schoner W, Scheiner-Bobis G.

Am J Physiol Cell Physiol. 2007 Aug;293(2):C509-36. Epub 2007 May 9. Review.


[Mechanisms for linking high salt intake to vascular tone: role of Na(+) pump and Na(+)/Ca²(+) exchanger coupling].

Kita S, Iwamoto T.

Yakugaku Zasshi. 2010 Nov;130(11):1399-405. Review. Japanese.


Endogenous ouabain in renal Na(+) handling and related diseases.

Manunta P, Messaggio E, Casamassima N, Gatti G, Carpini SD, Zagato L, Hamlyn JM.

Biochim Biophys Acta. 2010 Dec;1802(12):1214-8. doi: 10.1016/j.bbadis.2010.03.001. Epub 2010 Mar 11. Review.


Arterial α2-Na+ pump expression influences blood pressure: lessons from novel, genetically engineered smooth muscle-specific α2 mice.

Chen L, Song H, Wang Y, Lee JC, Kotlikoff MI, Pritchard TJ, Paul RJ, Zhang J, Blaustein MP.

Am J Physiol Heart Circ Physiol. 2015 Sep;309(5):H958-68. doi: 10.1152/ajpheart.00430.2015. Epub 2015 Jul 24.


The pump, the exchanger, and endogenous ouabain: signaling mechanisms that link salt retention to hypertension.

Blaustein MP, Zhang J, Chen L, Song H, Raina H, Kinsey SP, Izuka M, Iwamoto T, Kotlikoff MI, Lingrel JB, Philipson KD, Wier WG, Hamlyn JM.

Hypertension. 2009 Feb;53(2):291-8. doi: 10.1161/HYPERTENSIONAHA.108.119974. Epub 2008 Dec 22. Review. No abstract available.


Endogenous cardiotonic steroids and salt-sensitive hypertension.

Fedorova OV, Shapiro JI, Bagrov AY.

Biochim Biophys Acta. 2010 Dec;1802(12):1230-6. doi: 10.1016/j.bbadis.2010.03.011. Epub 2010 Mar 27. Review.


Hypertension, Na+/Ca2+ exchanger, and Na+, K+-ATPase.

Iwamoto T, Kita S.

Kidney Int. 2006 Jun;69(12):2148-54. Epub 2006 Apr 26. Review.


The sodium pump and cardiotonic steroids-induced signal transduction protein kinases and calcium-signaling microdomain in regulation of transporter trafficking.

Liu J, Xie ZJ.

Biochim Biophys Acta. 2010 Dec;1802(12):1237-45. doi: 10.1016/j.bbadis.2010.01.013. Epub 2010 Feb 6. Review.


Endogenous ouabain, sodium balance and blood pressure: a review and a hypothesis.

Hamlyn JM, Hamilton BP, Manunta P.

J Hypertens. 1996 Feb;14(2):151-67. Review.


Rostafuroxin: an ouabain-inhibitor counteracting specific forms of hypertension.

Ferrari P.

Biochim Biophys Acta. 2010 Dec;1802(12):1254-8. doi: 10.1016/j.bbadis.2010.01.009. Epub 2010 Jan 18. Review.


Salt-sensitive hypertension is triggered by Ca2+ entry via Na+/Ca2+ exchanger type-1 in vascular smooth muscle.

Iwamoto T, Kita S, Zhang J, Blaustein MP, Arai Y, Yoshida S, Wakimoto K, Komuro I, Katsuragi T.

Nat Med. 2004 Nov;10(11):1193-9. Epub 2004 Oct 10.


Normal pregnancy: mechanisms underlying the paradox of a ouabain-resistant state with elevated endogenous ouabain, suppressed arterial sodium calcium exchange, and low blood pressure.

Jacobs BE, Liu Y, Pulina MV, Golovina VA, Hamlyn JM.

Am J Physiol Heart Circ Physiol. 2012 Mar 15;302(6):H1317-29. doi: 10.1152/ajpheart.00532.2011. Epub 2012 Jan 13.

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