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Alternative end-joining is suppressed by the canonical NHEJ component Xrcc4-ligase IV during chromosomal translocation formation.

Simsek D, Jasin M.

Nat Struct Mol Biol. 2010 Apr;17(4):410-6. doi: 10.1038/nsmb.1773. Epub 2010 Mar 7.


DNA ligase III promotes alternative nonhomologous end-joining during chromosomal translocation formation.

Simsek D, Brunet E, Wong SY, Katyal S, Gao Y, McKinnon PJ, Lou J, Zhang L, Li J, Rebar EJ, Gregory PD, Holmes MC, Jasin M.

PLoS Genet. 2011 Jun;7(6):e1002080. doi: 10.1371/journal.pgen.1002080. Epub 2011 Jun 2.


Chromosomal translocations in human cells are generated by canonical nonhomologous end-joining.

Ghezraoui H, Piganeau M, Renouf B, Renaud JB, Sallmyr A, Ruis B, Oh S, Tomkinson AE, Hendrickson EA, Giovannangeli C, Jasin M, Brunet E.

Mol Cell. 2014 Sep 18;55(6):829-42. doi: 10.1016/j.molcel.2014.08.002. Epub 2014 Sep 4.


Genetic evidence for the involvement of DNA ligase IV in the DNA-PK-dependent pathway of non-homologous end joining in mammalian cells.

Wang H, Zeng ZC, Perrault AR, Cheng X, Qin W, Iliakis G.

Nucleic Acids Res. 2001 Apr 15;29(8):1653-60.


Marked contribution of alternative end-joining to chromosome-translocation-formation by stochastically induced DNA double-strand-breaks in G2-phase human cells.

Soni A, Siemann M, Pantelias GE, Iliakis G.

Mutat Res Genet Toxicol Environ Mutagen. 2015 Nov;793:2-8. doi: 10.1016/j.mrgentox.2015.07.002. Epub 2015 Jul 4.


Alternative end-joining catalyzes robust IgH locus deletions and translocations in the combined absence of ligase 4 and Ku70.

Boboila C, Jankovic M, Yan CT, Wang JH, Wesemann DR, Zhang T, Fazeli A, Feldman L, Nussenzweig A, Nussenzweig M, Alt FW.

Proc Natl Acad Sci U S A. 2010 Feb 16;107(7):3034-9. doi: 10.1073/pnas.0915067107. Epub 2010 Jan 25. Erratum in: Proc Natl Acad Sci U S A. 2013 Apr 2;110(14):5731.


DNA-dependent protein kinase and XRCC4-DNA ligase IV mobilization in the cell in response to DNA double strand breaks.

Drouet J, Delteil C, Lefrançois J, Concannon P, Salles B, Calsou P.

J Biol Chem. 2005 Feb 25;280(8):7060-9. Epub 2004 Oct 31.


Mechanisms of DNA double strand break repair and chromosome aberration formation.

Iliakis G, Wang H, Perrault AR, Boecker W, Rosidi B, Windhofer F, Wu W, Guan J, Terzoudi G, Pantelias G.

Cytogenet Genome Res. 2004;104(1-4):14-20. Review.


XLF interacts with the XRCC4-DNA ligase IV complex to promote DNA nonhomologous end-joining.

Ahnesorg P, Smith P, Jackson SP.

Cell. 2006 Jan 27;124(2):301-13.


C-Terminal region of DNA ligase IV drives XRCC4/DNA ligase IV complex to chromatin.

Liu S, Liu X, Kamdar RP, Wanotayan R, Sharma MK, Adachi N, Matsumoto Y.

Biochem Biophys Res Commun. 2013 Sep 20;439(2):173-8. doi: 10.1016/j.bbrc.2013.08.068. Epub 2013 Aug 28.


Loss of DNA ligase IV prevents recognition of DNA by double-strand break repair proteins XRCC4 and XLF.

Jayaram S, Ketner G, Adachi N, Hanakahi LA.

Nucleic Acids Res. 2008 Oct;36(18):5773-86. doi: 10.1093/nar/gkn552. Epub 2008 Sep 9.


Tetramerization and DNA ligase IV interaction of the DNA double-strand break repair protein XRCC4 are mutually exclusive.

Modesti M, Junop MS, Ghirlando R, van de Rakt M, Gellert M, Yang W, Kanaar R.

J Mol Biol. 2003 Nov 21;334(2):215-28.


Interplay between Cernunnos-XLF and nonhomologous end-joining proteins at DNA ends in the cell.

Wu PY, Frit P, Malivert L, Revy P, Biard D, Salles B, Calsou P.

J Biol Chem. 2007 Nov 2;282(44):31937-43. Epub 2007 Aug 24.


XRCC4 and XLF form long helical protein filaments suitable for DNA end protection and alignment to facilitate DNA double strand break repair.

Mahaney BL, Hammel M, Meek K, Tainer JA, Lees-Miller SP.

Biochem Cell Biol. 2013 Feb;91(1):31-41. doi: 10.1139/bcb-2012-0058. Epub 2013 Feb 5. Review.


Dynamic assembly of end-joining complexes requires interaction between Ku70/80 and XRCC4.

Mari PO, Florea BI, Persengiev SP, Verkaik NS, Brüggenwirth HT, Modesti M, Giglia-Mari G, Bezstarosti K, Demmers JA, Luider TM, Houtsmuller AB, van Gent DC.

Proc Natl Acad Sci U S A. 2006 Dec 5;103(49):18597-602. Epub 2006 Nov 21.


Monoubiquitination of the nonhomologous end joining protein XRCC4.

Foster RE, Nnakwe C, Woo L, Frank KM.

Biochem Biophys Res Commun. 2006 Mar 3;341(1):175-83. Epub 2006 Jan 6.


Defining interactions between DNA-PK and ligase IV/XRCC4.

Hsu HL, Yannone SM, Chen DJ.

DNA Repair (Amst). 2002 Mar 28;1(3):225-35.


Alternative end-joining catalyzes class switch recombination in the absence of both Ku70 and DNA ligase 4.

Boboila C, Yan C, Wesemann DR, Jankovic M, Wang JH, Manis J, Nussenzweig A, Nussenzweig M, Alt FW.

J Exp Med. 2010 Feb 15;207(2):417-27. doi: 10.1084/jem.20092449. Epub 2010 Feb 8. Erratum in: J Exp Med. 2013 Mar 11;210(3):641.


Biochemical evidence for Ku-independent backup pathways of NHEJ.

Wang H, Perrault AR, Takeda Y, Qin W, Wang H, Iliakis G.

Nucleic Acids Res. 2003 Sep 15;31(18):5377-88.

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