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Items: 1 to 20 of 278

2.

Phosphorylation of CDK9 at Ser175 enhances HIV transcription and is a marker of activated P-TEFb in CD4(+) T lymphocytes.

Mbonye UR, Gokulrangan G, Datt M, Dobrowolski C, Cooper M, Chance MR, Karn J.

PLoS Pathog. 2013;9(5):e1003338. doi: 10.1371/journal.ppat.1003338.

3.

Release of positive transcription elongation factor b (P-TEFb) from 7SK small nuclear ribonucleoprotein (snRNP) activates hexamethylene bisacetamide-inducible protein (HEXIM1) transcription.

Liu P, Xiang Y, Fujinaga K, Bartholomeeusen K, Nilson KA, Price DH, Peterlin BM.

J Biol Chem. 2014 Apr 4;289(14):9918-25. doi: 10.1074/jbc.M113.539015.

4.

Two-pronged binding with bromodomain-containing protein 4 liberates positive transcription elongation factor b from inactive ribonucleoprotein complexes.

Schröder S, Cho S, Zeng L, Zhang Q, Kaehlcke K, Mak L, Lau J, Bisgrove D, Schnölzer M, Verdin E, Zhou MM, Ott M.

J Biol Chem. 2012 Jan 6;287(2):1090-9. doi: 10.1074/jbc.M111.282855.

5.
6.

Bromodomain protein Brd4 regulates human immunodeficiency virus transcription through phosphorylation of CDK9 at threonine 29.

Zhou M, Huang K, Jung KJ, Cho WK, Klase Z, Kashanchi F, Pise-Masison CA, Brady JN.

J Virol. 2009 Jan;83(2):1036-44. doi: 10.1128/JVI.01316-08.

7.

Human T-lymphotropic virus type 1 Tax protein complexes with P-TEFb and competes for Brd4 and 7SK snRNP/HEXIM1 binding.

Cho WK, Jang MK, Huang K, Pise-Masison CA, Brady JN.

J Virol. 2010 Dec;84(24):12801-9. doi: 10.1128/JVI.00943-10.

8.

Binding of the 7SK snRNA turns the HEXIM1 protein into a P-TEFb (CDK9/cyclin T) inhibitor.

Michels AA, Fraldi A, Li Q, Adamson TE, Bonnet F, Nguyen VT, Sedore SC, Price JP, Price DH, Lania L, Bensaude O.

EMBO J. 2004 Jul 7;23(13):2608-19.

9.

The CDK9/cyclin T1 subunits of P-TEFb in mouse oocytes and preimplantation embryos: a possible role in embryonic genome activation.

Oqani RK, Kim HR, Diao YF, Park CS, Jin DI.

BMC Dev Biol. 2011 Jun 3;11:33. doi: 10.1186/1471-213X-11-33.

12.

PP2B and PP1alpha cooperatively disrupt 7SK snRNP to release P-TEFb for transcription in response to Ca2+ signaling.

Chen R, Liu M, Li H, Xue Y, Ramey WN, He N, Ai N, Luo H, Zhu Y, Zhou N, Zhou Q.

Genes Dev. 2008 May 15;22(10):1356-68. doi: 10.1101/gad.1636008.

13.
14.

Bromodomain and extra-terminal (BET) bromodomain inhibition activate transcription via transient release of positive transcription elongation factor b (P-TEFb) from 7SK small nuclear ribonucleoprotein.

Bartholomeeusen K, Xiang Y, Fujinaga K, Peterlin BM.

J Biol Chem. 2012 Oct 19;287(43):36609-16. doi: 10.1074/jbc.M112.410746. Erratum in: J Biol Chem. 2013 Apr 26;288(17):12214.

15.

Regulation of P-TEFb elongation complex activity by CDK9 acetylation.

Fu J, Yoon HG, Qin J, Wong J.

Mol Cell Biol. 2007 Jul;27(13):4641-51.

16.

Inhibition of P-TEFb (CDK9/Cyclin T) kinase and RNA polymerase II transcription by the coordinated actions of HEXIM1 and 7SK snRNA.

Yik JH, Chen R, Nishimura R, Jennings JL, Link AJ, Zhou Q.

Mol Cell. 2003 Oct;12(4):971-82.

17.

MAQ1 and 7SK RNA interact with CDK9/cyclin T complexes in a transcription-dependent manner.

Michels AA, Nguyen VT, Fraldi A, Labas V, Edwards M, Bonnet F, Lania L, Bensaude O.

Mol Cell Biol. 2003 Jul;23(14):4859-69. Erratum in: Mol Cell Biol. 2003 Dec;23(24):9405.

18.

Recruitment of P-TEFb for stimulation of transcriptional elongation by the bromodomain protein Brd4.

Yang Z, Yik JH, Chen R, He N, Jang MK, Ozato K, Zhou Q.

Mol Cell. 2005 Aug 19;19(4):535-45.

19.

CDK9 autophosphorylation regulates high-affinity binding of the human immunodeficiency virus type 1 tat-P-TEFb complex to TAR RNA.

Garber ME, Mayall TP, Suess EM, Meisenhelder J, Thompson NE, Jones KA.

Mol Cell Biol. 2000 Sep;20(18):6958-69.

20.

P-TEFb kinase complex phosphorylates histone H1 to regulate expression of cellular and HIV-1 genes.

O'Brien SK, Cao H, Nathans R, Ali A, Rana TM.

J Biol Chem. 2010 Sep 24;285(39):29713-20. doi: 10.1074/jbc.M110.125997.

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