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Items: 1 to 20 of 116

1.

Induction of autophagy-dependent necroptosis is required for childhood acute lymphoblastic leukemia cells to overcome glucocorticoid resistance.

Bonapace L, Bornhauser BC, Schmitz M, Cario G, Ziegler U, Niggli FK, Schäfer BW, Schrappe M, Stanulla M, Bourquin JP.

J Clin Invest. 2010 Apr;120(4):1310-23. doi: 10.1172/JCI39987.

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Obatoclax induces Atg7-dependent autophagy independent of beclin-1 and BAX/BAK.

McCoy F, Hurwitz J, McTavish N, Paul I, Barnes C, O'Hagan B, Odrzywol K, Murray J, Longley D, McKerr G, Fennell DA.

Cell Death Dis. 2010 Dec 16;1:e108. doi: 10.1038/cddis.2010.86.

4.

Inhibition of autophagy overcomes glucocorticoid resistance in lymphoid malignant cells.

Jiang L, Xu L, Xie J, Li S, Guan Y, Zhang Y, Hou Z, Guo T, Shu X, Wang C, Fan W, Si Y, Yang Y, Kang Z, Fang M, Liu Q.

Cancer Biol Ther. 2015;16(3):466-76. doi: 10.1080/15384047.2015.1016658.

5.

Potent obatoclax cytotoxicity and activation of triple death mode killing across infant acute lymphoblastic leukemia.

Urtishak KA, Edwards AY, Wang LS, Hudome A, Robinson BW, Barrett JS, Cao K, Cory L, Moore JS, Bantly AD, Yu QC, Chen IM, Atlas SR, Willman CL, Kundu M, Carroll AJ, Heerema NA, Devidas M, Hilden JM, Dreyer ZE, Hunger SP, Reaman GH, Felix CA.

Blood. 2013 Apr 4;121(14):2689-703. doi: 10.1182/blood-2012-04-425033. Epub 2013 Feb 7.

6.

Co-targeting of Bcl-2 and mTOR pathway triggers synergistic apoptosis in BH3 mimetics resistant acute lymphoblastic leukemia.

Iacovelli S, Ricciardi MR, Allegretti M, Mirabilii S, Licchetta R, Bergamo P, Rinaldo C, Zeuner A, Foà R, Milella M, McCubrey JA, Martelli AM, Tafuri A.

Oncotarget. 2015 Oct 13;6(31):32089-103. doi: 10.18632/oncotarget.5156.

7.

Inhibition of Bcl-2 antiapoptotic members by obatoclax potently enhances sorafenib-induced apoptosis in human myeloid leukemia cells through a Bim-dependent process.

Rahmani M, Aust MM, Attkisson E, Williams DC Jr, Ferreira-Gonzalez A, Grant S.

Blood. 2012 Jun 21;119(25):6089-98. doi: 10.1182/blood-2011-09-378141. Epub 2012 Mar 23.

8.

Bafilomycin A1 targets both autophagy and apoptosis pathways in pediatric B-cell acute lymphoblastic leukemia.

Yuan N, Song L, Zhang S, Lin W, Cao Y, Xu F, Fang Y, Wang Z, Zhang H, Li X, Wang Z, Cai J, Wang J, Zhang Y, Mao X, Zhao W, Hu S, Chen S, Wang J.

Haematologica. 2015 Mar;100(3):345-56. doi: 10.3324/haematol.2014.113324. Epub 2014 Dec 15.

9.

Idarubicin induces mTOR-dependent cytotoxic autophagy in leukemic cells.

Ristic B, Bosnjak M, Arsikin K, Mircic A, Suzin-Zivkovic V, Bogdanovic A, Perovic V, Martinovic T, Kravic-Stevovic T, Bumbasirevic V, Trajkovic V, Harhaji-Trajkovic L.

Exp Cell Res. 2014 Aug 1;326(1):90-102. doi: 10.1016/j.yexcr.2014.05.021. Epub 2014 Jun 5.

PMID:
24907655
10.

A JNK-mediated autophagy pathway that triggers c-IAP degradation and necroptosis for anticancer chemotherapy.

He W, Wang Q, Srinivasan B, Xu J, Padilla MT, Li Z, Wang X, Liu Y, Gou X, Shen HM, Xing C, Lin Y.

Oncogene. 2014 Jun 5;33(23):3004-13. doi: 10.1038/onc.2013.256. Epub 2013 Jul 8.

11.

Low-dose arsenic trioxide sensitizes glucocorticoid-resistant acute lymphoblastic leukemia cells to dexamethasone via an Akt-dependent pathway.

Bornhauser BC, Bonapace L, Lindholm D, Martinez R, Cario G, Schrappe M, Niggli FK, Schäfer BW, Bourquin JP.

Blood. 2007 Sep 15;110(6):2084-91. Epub 2007 May 30.

12.

Glucocorticoid sensitisation in Mixed Lineage Leukaemia-rearranged acute lymphoblastic leukaemia by the pan-BCL-2 family inhibitors gossypol and AT-101.

Spijkers-Hagelstein JA, Schneider P, Pinhanços SM, Garrido Castro P, Pieters R, Stam RW.

Eur J Cancer. 2014 Jun;50(9):1665-74. doi: 10.1016/j.ejca.2014.03.011. Epub 2014 Apr 3.

PMID:
24703900
13.

RFX1-dependent activation of SHP-1 induces autophagy by a novel obatoclax derivative in hepatocellular carcinoma cells.

Su JC, Tseng PH, Hsu CY, Tai WT, Huang JW, Ko CH, Lin MW, Liu CY, Chen KF, Shiau CW.

Oncotarget. 2014 Jul 15;5(13):4909-19.

14.

Opposing regulation of BIM and BCL2 controls glucocorticoid-induced apoptosis of pediatric acute lymphoblastic leukemia cells.

Jing D, Bhadri VA, Beck D, Thoms JA, Yakob NA, Wong JW, Knezevic K, Pimanda JE, Lock RB.

Blood. 2015 Jan 8;125(2):273-83. doi: 10.1182/blood-2014-05-576470. Epub 2014 Oct 21.

15.

Concurrent inhibition of PI3K and mTORC1/mTORC2 overcomes resistance to rapamycin induced apoptosis by down-regulation of Mcl-1 in mantle cell lymphoma.

Müller A, Zang C, Chumduri C, Dörken B, Daniel PT, Scholz CW.

Int J Cancer. 2013 Oct 15;133(8):1813-24. doi: 10.1002/ijc.28206. Epub 2013 Jun 15.

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Pentagalloylglucose induces autophagy and caspase-independent programmed deaths in human PC-3 and mouse TRAMP-C2 prostate cancer cells.

Hu H, Chai Y, Wang L, Zhang J, Lee HJ, Kim SH, Lü J.

Mol Cancer Ther. 2009 Oct;8(10):2833-43. doi: 10.1158/1535-7163.MCT-09-0288.

18.

Gamma-secretase inhibitors reverse glucocorticoid resistance in T cell acute lymphoblastic leukemia.

Real PJ, Tosello V, Palomero T, Castillo M, Hernando E, de Stanchina E, Sulis ML, Barnes K, Sawai C, Homminga I, Meijerink J, Aifantis I, Basso G, Cordon-Cardo C, Ai W, Ferrando A.

Nat Med. 2009 Jan;15(1):50-8. doi: 10.1038/nm.1900. Epub 2008 Dec 21.

19.

FTY720 induces autophagy-related apoptosis and necroptosis in human glioblastoma cells.

Zhang L, Wang H, Ding K, Xu J.

Toxicol Lett. 2015 Jul 2;236(1):43-59. doi: 10.1016/j.toxlet.2015.04.015. Epub 2015 May 1.

PMID:
25939952
20.

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