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A deneddylase encoded by Epstein-Barr virus promotes viral DNA replication by regulating the activity of cullin-RING ligases.

Gastaldello S, Hildebrand S, Faridani O, Callegari S, Palmkvist M, Di Guglielmo C, Masucci MG.

Nat Cell Biol. 2010 Apr;12(4):351-61. doi: 10.1038/ncb2035. Epub 2010 Feb 28.


Caspase-1 promotes Epstein-Barr virus replication by targeting the large tegument protein deneddylase to the nucleus of productively infected cells.

Gastaldello S, Chen X, Callegari S, Masucci MG.

PLoS Pathog. 2013;9(10):e1003664. doi: 10.1371/journal.ppat.1003664. Epub 2013 Oct 10.


The Translesion Polymerase Pol η Is Required for Efficient Epstein-Barr Virus Infectivity and Is Regulated by the Viral Deubiquitinating Enzyme BPLF1.

Dyson OF, Pagano JS, Whitehurst CB.

J Virol. 2017 Sep 12;91(19). pii: e00600-17. doi: 10.1128/JVI.00600-17. Print 2017 Oct 1.


The Rad6/18 ubiquitin complex interacts with the Epstein-Barr virus deubiquitinating enzyme, BPLF1, and contributes to virus infectivity.

Kumar R, Whitehurst CB, Pagano JS.

J Virol. 2014 Jun;88(11):6411-22. doi: 10.1128/JVI.00536-14. Epub 2014 Mar 26.


Herpes virus deneddylases interrupt the cullin-RING ligase neddylation cycle by inhibiting the binding of CAND1.

Gastaldello S, Callegari S, Coppotelli G, Hildebrand S, Song M, Masucci MG.

J Mol Cell Biol. 2012 Aug;4(4):242-51. doi: 10.1093/jmcb/mjs012. Epub 2012 Apr 3.


Epstein-Barr virus BPLF1 deubiquitinates PCNA and attenuates polymerase η recruitment to DNA damage sites.

Whitehurst CB, Vaziri C, Shackelford J, Pagano JS.

J Virol. 2012 Aug;86(15):8097-106. doi: 10.1128/JVI.00588-12. Epub 2012 May 23.


Herpesvirus deconjugases inhibit the IFN response by promoting TRIM25 autoubiquitination and functional inactivation of the RIG-I signalosome.

Gupta S, Ylä-Anttila P, Callegari S, Tsai MH, Delecluse HJ, Masucci MG.

PLoS Pathog. 2018 Jan 22;14(1):e1006852. doi: 10.1371/journal.ppat.1006852. eCollection 2018 Jan.


In vitro cleavage of Nedd8 from cullin 1 by COP9 signalosome and deneddylase 1.

Yamoah K, Wu K, Pan ZQ.

Methods Enzymol. 2005;398:509-22.


Inhibition of NEDD8-activating enzyme induces rereplication and apoptosis in human tumor cells consistent with deregulating CDT1 turnover.

Milhollen MA, Narayanan U, Soucy TA, Veiby PO, Smith PG, Amidon B.

Cancer Res. 2011 Apr 15;71(8):3042-51. doi: 10.1158/0008-5472.CAN-10-2122. Epub 2011 Apr 12.


The reading frame BPLF1 of Epstein-Barr virus: a homologue of herpes simplex virus protein VP16.

Schmaus S, Wolf H, Schwarzmann F.

Virus Genes. 2004 Oct;29(2):267-77.


The Epstein-Barr virus (EBV) deubiquitinating enzyme BPLF1 reduces EBV ribonucleotide reductase activity.

Whitehurst CB, Ning S, Bentz GL, Dufour F, Gershburg E, Shackelford J, Langelier Y, Pagano JS.

J Virol. 2009 May;83(9):4345-53. doi: 10.1128/JVI.02195-08. Epub 2009 Feb 25.


Epstein-Barr virus large tegument protein BPLF1 contributes to innate immune evasion through interference with toll-like receptor signaling.

van Gent M, Braem SG, de Jong A, Delagic N, Peeters JG, Boer IG, Moynagh PN, Kremmer E, Wiertz EJ, Ovaa H, Griffin BD, Ressing ME.

PLoS Pathog. 2014 Feb 20;10(2):e1003960. doi: 10.1371/journal.ppat.1003960. eCollection 2014 Feb.


CAND1 enhances deneddylation of CUL1 by COP9 signalosome.

Min KW, Kwon MJ, Park HS, Park Y, Yoon SK, Yoon JB.

Biochem Biophys Res Commun. 2005 Sep 2;334(3):867-74.


Deneddylase 1 regulates deneddylase activity of the Cop9 signalosome in Drosophila melanogaster.

Kim K, Yoon J, Yim J, Kim HJ.

Insect Sci. 2017 Feb;24(1):27-34. doi: 10.1111/1744-7917.12274. Epub 2015 Nov 18.


Destabilization of CDC6 upon DNA damage is dependent on neddylation but independent of Cullin E3 ligases.

Tan CY, Hagen T.

Int J Biochem Cell Biol. 2013 Jul;45(7):1489-98. doi: 10.1016/j.biocel.2013.04.010. Epub 2013 Apr 15.


The Epstein-Barr Virus Immunoevasins BCRF1 and BPLF1 Are Expressed by a Mechanism Independent of the Canonical Late Pre-initiation Complex.

McKenzie J, Lopez-Giraldez F, Delecluse HJ, Walsh A, El-Guindy A.

PLoS Pathog. 2016 Nov 17;12(11):e1006008. doi: 10.1371/journal.ppat.1006008. eCollection 2016 Nov.


Regulation of neddylation and deneddylation of cullin1 in SCFSkp2 ubiquitin ligase by F-box protein and substrate.

Bornstein G, Ganoth D, Hershko A.

Proc Natl Acad Sci U S A. 2006 Aug 1;103(31):11515-20. Epub 2006 Jul 21.


Characterization of the role of COP9 signalosome in regulating cullin E3 ubiquitin ligase activity.

Choo YY, Boh BK, Lou JJ, Eng J, Leck YC, Anders B, Smith PG, Hagen T.

Mol Biol Cell. 2011 Dec;22(24):4706-15. doi: 10.1091/mbc.E11-03-0251. Epub 2011 Oct 19.


Inhibition of cullin RING ligases by cycle inhibiting factor: evidence for interference with Nedd8-induced conformational control.

Boh BK, Ng MY, Leck YC, Shaw B, Long J, Sun GW, Gan YH, Searle MS, Layfield R, Hagen T.

J Mol Biol. 2011 Oct 21;413(2):430-7. doi: 10.1016/j.jmb.2011.08.030. Epub 2011 Aug 29.


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