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TACE activation by MAPK-mediated regulation of cell surface dimerization and TIMP3 association.

Xu P, Liu J, Sakaki-Yumoto M, Derynck R.

Sci Signal. 2012 May 1;5(222):ra34. doi: 10.1126/scisignal.2002689.


Helicobacter pylori-induced gastric mucosal TGF-α ectodomain shedding and EGFR transactivation involves Rac1/p38 MAPK-dependent TACE activation.

Slomiany BL, Slomiany A.

Inflammopharmacology. 2016 Feb;24(1):23-31. doi: 10.1007/s10787-015-0254-z. Epub 2015 Dec 10.


Ectodomain shedding of pro-TGF-alpha is required for COX-2 induction and cell survival in renal medullary cells exposed to osmotic stress.

Küper C, Bartels H, Fraek ML, Beck FX, Neuhofer W.

Am J Physiol Cell Physiol. 2007 Dec;293(6):C1971-82. Epub 2007 Oct 17.


Metalloprotease-dependent protransforming growth factor-alpha ectodomain shedding in the absence of tumor necrosis factor-alpha-converting enzyme.

Merlos-Suárez A, Ruiz-Paz S, Baselga J, Arribas J.

J Biol Chem. 2001 Dec 21;276(51):48510-7. Epub 2001 Oct 12.


Mitochondrial reactive oxygen species mediate GPCR-induced TACE/ADAM17-dependent transforming growth factor-alpha shedding.

Myers TJ, Brennaman LH, Stevenson M, Higashiyama S, Russell WE, Lee DC, Sunnarborg SW.

Mol Biol Cell. 2009 Dec;20(24):5236-49. doi: 10.1091/mbc.E08-12-1256.


TACE-mediated ectodomain shedding of the type I TGF-beta receptor downregulates TGF-beta signaling.

Liu C, Xu P, Lamouille S, Xu J, Derynck R.

Mol Cell. 2009 Jul 10;35(1):26-36. doi: 10.1016/j.molcel.2009.06.018.


The transmembrane domain of TACE regulates protein ectodomain shedding.

Li X, Pérez L, Pan Z, Fan H.

Cell Res. 2007 Dec;17(12):985-98.


A transforming Src mutant increases the bioavailability of EGFR ligands via stimulation of the cell-surface metalloproteinase ADAM17.

Maretzky T, Zhou W, Huang XY, Blobel CP.

Oncogene. 2011 Feb 3;30(5):611-8. doi: 10.1038/onc.2010.443. Epub 2010 Sep 27.


TACE/ADAM-17: a component of the epidermal growth factor receptor axis and a promising therapeutic target in colorectal cancer.

Merchant NB, Voskresensky I, Rogers CM, Lafleur B, Dempsey PJ, Graves-Deal R, Revetta F, Foutch AC, Rothenberg ML, Washington MK, Coffey RJ.

Clin Cancer Res. 2008 Feb 15;14(4):1182-91. doi: 10.1158/1078-0432.CCR-07-1216.


Caveolin-1 is required for TGF-β-induced transactivation of the EGF receptor pathway in hepatocytes through the activation of the metalloprotease TACE/ADAM17.

Moreno-Càceres J, Caja L, Mainez J, Mayoral R, Martín-Sanz P, Moreno-Vicente R, Del Pozo MÁ, Dooley S, Egea G, Fabregat I.

Cell Death Dis. 2014 Jul 17;5:e1326. doi: 10.1038/cddis.2014.294.


Cytotrienin A, a translation inhibitor that induces ectodomain shedding of TNF receptor 1 via activation of ERK and p38 MAP kinase.

Yamada Y, Taketani S, Osada H, Kataoka T.

Eur J Pharmacol. 2011 Sep 30;667(1-3):113-9. doi: 10.1016/j.ejphar.2011.05.072. Epub 2011 Jun 6.


A biosensor for the activity of the "sheddase" TACE (ADAM17) reveals novel and cell type-specific mechanisms of TACE activation.

Chapnick DA, Bunker E, Liu X.

Sci Signal. 2015 Feb 24;8(365):rs1. doi: 10.1126/scisignal.2005680.


Migration of growth factor-stimulated epithelial and endothelial cells depends on EGFR transactivation by ADAM17.

Maretzky T, Evers A, Zhou W, Swendeman SL, Wong PM, Rafii S, Reiss K, Blobel CP.

Nat Commun. 2011;2:229. doi: 10.1038/ncomms1232.

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