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Synphilin-1 attenuates neuronal degeneration in the A53T alpha-synuclein transgenic mouse model.

Smith WW, Liu Z, Liang Y, Masuda N, Swing DA, Jenkins NA, Copeland NG, Troncoso JC, Pletnikov M, Dawson TM, Martin LJ, Moran TH, Lee MK, Borchelt DR, Ross CA.

Hum Mol Genet. 2010 Jun 1;19(11):2087-98. doi: 10.1093/hmg/ddq086.


alpha-Synuclein is colocalized with 14-3-3 and synphilin-1 in A53T transgenic mice.

Shirakashi Y, Kawamoto Y, Tomimoto H, Takahashi R, Ihara M.

Acta Neuropathol. 2006 Dec;112(6):681-9.


Overexpression of synphilin-1 promotes clearance of soluble and misfolded alpha-synuclein without restoring the motor phenotype in aged A30P transgenic mice.

Casadei N, Pöhler AM, Tomás-Zapico C, Torres-Peraza J, Schwedhelm I, Witz A, Zamolo I, De Heer R, Spruijt B, Noldus LP, Klucken J, Lucas JJ, Kahle PJ, Krüger R, Riess O, Nuber S.

Hum Mol Genet. 2014 Feb 1;23(3):767-81. doi: 10.1093/hmg/ddt467.


Synphilin isoforms and the search for a cellular model of lewy body formation in Parkinson's disease.

Eyal A, Engelender S.

Cell Cycle. 2006 Sep;5(18):2082-6. Review.


Transgenic overexpression of the alpha-synuclein interacting protein synphilin-1 leads to behavioral and neuropathological alterations in mice.

Nuber S, Franck T, Wolburg H, Schumann U, Casadei N, Fischer K, Calaminus C, Pichler BJ, Chanarat S, Teismann P, Schulz JB, Luft AR, Tomiuk J, Wilbertz J, Bornemann A, Krüger R, Riess O.

Neurogenetics. 2010 Feb;11(1):107-20. doi: 10.1007/s10048-009-0212-2.


Ubiquitylation of synphilin-1 and alpha-synuclein by SIAH and its presence in cellular inclusions and Lewy bodies imply a role in Parkinson's disease.

Liani E, Eyal A, Avraham E, Shemer R, Szargel R, Berg D, Bornemann A, Riess O, Ross CA, Rott R, Engelender S.

Proc Natl Acad Sci U S A. 2004 Apr 13;101(15):5500-5.


Synphilin-1A: an aggregation-prone isoform of synphilin-1 that causes neuronal death and is present in aggregates from alpha-synucleinopathy patients.

Eyal A, Szargel R, Avraham E, Liani E, Haskin J, Rott R, Engelender S.

Proc Natl Acad Sci U S A. 2006 Apr 11;103(15):5917-22.


Aggregate formation and toxicity by wild-type and R621C synphilin-1 in the nigrostriatal system of mice using adenoviral vectors.

Krenz A, Falkenburger BH, Gerhardt E, Drinkut A, Schulz JB.

J Neurochem. 2009 Jan;108(1):139-46. doi: 10.1111/j.1471-4159.2008.05755.x.


Synphilin-1 attenuates mutant LRRK2-induced neurodegeneration in Parkinson's disease models.

Liu J, Li T, Thomas JM, Pei Z, Jiang H, Engelender S, Ross CA, Smith WW.

Hum Mol Genet. 2016 Feb 15;25(4):672-80. doi: 10.1093/hmg/ddv504.


Altered α-synuclein, parkin, and synphilin isoform levels in multiple system atrophy brains.

Brudek T, Winge K, Rasmussen NB, Bahl JM, Tanassi J, Agander TK, Hyde TM, Pakkenberg B.

J Neurochem. 2016 Jan;136(1):172-85. doi: 10.1111/jnc.13392.


Parkin ubiquitinates the alpha-synuclein-interacting protein, synphilin-1: implications for Lewy-body formation in Parkinson disease.

Chung KK, Zhang Y, Lim KL, Tanaka Y, Huang H, Gao J, Ross CA, Dawson VL, Dawson TM.

Nat Med. 2001 Oct;7(10):1144-50.


Synphilin-1 associates with alpha-synuclein and promotes the formation of cytosolic inclusions.

Engelender S, Kaminsky Z, Guo X, Sharp AH, Amaravi RK, Kleiderlein JJ, Margolis RL, Troncoso JC, Lanahan AA, Worley PF, Dawson VL, Dawson TM, Ross CA.

Nat Genet. 1999 May;22(1):110-4.


Interaction of alpha-synuclein and synphilin-1: effect of Parkinson's disease-associated mutations.

Kawamata H, McLean PJ, Sharma N, Hyman BT.

J Neurochem. 2001 May;77(3):929-34.


Parkinson's disease alpha-synuclein transgenic mice develop neuronal mitochondrial degeneration and cell death.

Martin LJ, Pan Y, Price AC, Sterling W, Copeland NG, Jenkins NA, Price DL, Lee MK.

J Neurosci. 2006 Jan 4;26(1):41-50.


Synphilin-1 isoforms in Parkinson's disease: regulation by phosphorylation and ubiquitylation.

Szargel R, Rott R, Engelender S.

Cell Mol Life Sci. 2008 Jan;65(1):80-8. Review.


Neuropathology in mice expressing human alpha-synuclein.

van der Putten H, Wiederhold KH, Probst A, Barbieri S, Mistl C, Danner S, Kauffmann S, Hofele K, Spooren WP, Ruegg MA, Lin S, Caroni P, Sommer B, Tolnay M, Bilbe G.

J Neurosci. 2000 Aug 15;20(16):6021-9.


Aggresomes formed by alpha-synuclein and synphilin-1 are cytoprotective.

Tanaka M, Kim YM, Lee G, Junn E, Iwatsubo T, Mouradian MM.

J Biol Chem. 2004 Feb 6;279(6):4625-31.


Periphilin is a novel interactor of synphilin-1, a protein implicated in Parkinson's disease.

Soehn AS, Franck T, Biskup S, Giaime E, Melle C, Rott R, Cebo D, Kalbacher H, Ott E, Pahnke J, Meitinger T, Krüger R, Gasser T, Berg D, von Eggeling F, Engelender S, da Costa CA, Riess O.

Neurogenetics. 2010 May;11(2):203-15. doi: 10.1007/s10048-009-0215-z.


Neurodegenerative phenotypes in an A53T α-synuclein transgenic mouse model are independent of LRRK2.

Daher JP, Pletnikova O, Biskup S, Musso A, Gellhaar S, Galter D, Troncoso JC, Lee MK, Dawson TM, Dawson VL, Moore DJ.

Hum Mol Genet. 2012 Jun 1;21(11):2420-31. doi: 10.1093/hmg/dds057.


Identification and functional characterization of a novel R621C mutation in the synphilin-1 gene in Parkinson's disease.

Marx FP, Holzmann C, Strauss KM, Li L, Eberhardt O, Gerhardt E, Cookson MR, Hernandez D, Farrer MJ, Kachergus J, Engelender S, Ross CA, Berger K, Schöls L, Schulz JB, Riess O, Krüger R.

Hum Mol Genet. 2003 Jun 1;12(11):1223-31.

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