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20185198,21503906,17400303,17561304,17516533,19222742,19665408,17244449,18343270,19780875,19586679,19119245,19637288,19323782,20549958,22358132,21143368,21036792,16611191,20659226,23742912,16461777,17256746,24630505,18433925,21777282,22246827,22688509,21716122,15259898,23096938,17988233,17637268,15838891,20646776,17310821,20367795,19550344,18221300,19626620,22939662,19008175,20927588,23690184,23026293,19052126,16729316,16789011,24440937,23194375,18312291,23197889,20678438,22260834,18367858,19874686,16757589,22433304,19656287,23967738,21149924,22878399,16871563,18572751,22930504,20621632,19196395,29151700,22892524,12143057,18461609,22053372,19578241,20185191,19152408,17854034,19195324,20332649,26523269,19918102,16317671,19712848,25320730,18795900,21883327,24710668,17196132,14997399,16481305,20600025,20586936,23627034,17692425,24203098,19319954,25742145,21311107,17125603,25732900,25028473,25132017,15655050,14647053,12829991,22452737,23301548,17237626,19387534,25303802,23186591,21374657,15964093,23543447,18822888,16338024,25872678,17402992,21186534,22464779,22960601,16799983,17321635,25788197,17713154,16274835,25605989,20032544,25716029,19229115,23134956,16641397,15915463,22138714,22226087,17971947,25956353,23929069,21334762,17696224,18199519,22028068,21486869,21513743,14699491,23593607,25287170,24741905,23505208,25983054,24964070,19674281,19818142,21941420,22147982,17898551,22585719,17683493,15288618,19107976,22728692,17854030,21692935,24517926,10869300,22098177,23689059,21253834,20729619,17697727,23301549,14655682,20012680,19302908,19998272,19263474,19497209,14699490,24330475,27538443,16386596,17086064,23517019,17567633,25247889,15973721,26322642,17431777,17332007,22430972,30882363,17713159,14642631,24478474,22390049,16177549,22078148,16293338,20403388,15500383,17241380,20648601,25493022,25624410,19175883,17302381,20498322,18279995,20091678,23629601,24836314,18578989,23408582,28011962,19725909,23317201,21311111,22301217,16982790,21806648,24133665,21911882,22257108,12500185,16524892,15564749,21186536,27894395,21392168,12753143,27023755,21149926,15948869,25712861,17547362,25976382,16168522,28322924,17030194,15561234,25168842,15866639,14738561,20580309,33711338,17404847,26032700,24100506,18572757,12548513,25032183,27079793,16732905,27016894,12447726,28088502,17075492,12447727,17913933,17935165,16448447,22796241,26598028,20558919,17503746,22242973,26983387,31130119,17339249,11959607,24583110,16314804,25034491,18008227,21696601,22097972,19028525,28127204,26079809,32840739,27711135,17244247,25852125,26110616,24351112,27694733,16855278,17984230,19100231,20875460,24064642,12616453,16378967,21205485,11050059,17075491,24586482,22290465,27792585,15048802,19651117,18331765,17112914,18605187,27787680,14974332,20678449,27492206,15324948,24316031,22342116,19458467,25911883,17515708,27896895,16649389,20119580,24579475,25982306,23487374,23022497,24890161,12727536,28500726,24175847,24620920,24160943,21485198,15975684,20222172,15168763,32569703,23261845,21816062,22310790,18804309,17983813,19602924,19019484,17988612,22053385,19110664,25481755,20449785,19041345,25320731,17917412,27006281,17229858,18567076,16506363,18815461,11074477,14756274,17561492,26612031,23796863,20646332,22668794,18606836,12448687,24790911,22666402,12076749,20226208,25838313,24118725,26531675,15591521,27649318,29065883,25882358,19065672,23627028,18397486,11437320,19486254,23918533,11511568,21993835,18822213,32216026,22404035,20626626,30789375,23098450,24630522,16029585,17917393,31880877,18391895,14557667,25917965,29119303,32087080,30075160,18211717,15682483,24835494,15192795,16757620,25034493,12441815,26876337,12851876,23155338,22971278,19222103,19077481,15104374,16628682,24957725,24030850,24587198,15482214,23269882,18081660,9581787,17224847,17184802,24914332,32189364,23023011,23114756,15188170,21777281,23924587,15307884,15457964,23160952,20888661,14647043,16472619,12606741,12631687,23355917,25203736,23730843,11709523,15981622,14749147,11825543,17309424,28300730,25587617,12875056,14736963,27354181,17948940,30906435,11745928,24237431,27313669,23990707,18662609,25821965,28303969,28316253,10762559,20001153,10996115,16484132,10377169,19301976,20944991,33124952,21933446,27252524,21937397,31105017,23602529,23123221,31130120,35487093,18571815,23773806,12866303,25382636,19192171,20164224,22174548,24085784,25997324,15155222,16611195,23346997,20563485,15778519,11449155,23808774,29859062,11397660,34517459,14708694,20007398,23871771,28017671,24569300,14699512,23403838,27504160,27602500,26136470,24574300,29393485,25439100,34292864,19889778,29271185,29093313,19669311,9551691,29082648,20978280,12044531,23467016,16568374,20890947,12586297,23272650,17729422,25034492,11038017,17075493,15453144,17917394,27877054,18618250,15357648,16880074,18467302,31600164,17075494,21508187,23103614,24901840,23687840,30339311,9007704,20675280,35514268,26727850,25892855,18418959,31272463,23907754,21866665,25751382,17641552,23913814,25786446,21321415,16260913,25034490,25633447,22946668,18837083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726 results

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Evolution of full-length HBV sequences in chronic hepatitis B patients with sequential lamivudine and adefovir dipivoxil resistance.

Chen CH, Lee CM, Tung WC, Wang JH, Hung CH, Hu TH, Wang JC, Lu SN, Changchien CS. Chen CH, et al. J Hepatol. 2010 Apr;52(4):478-85. doi: 10.1016/j.jhep.2010.01.006. Epub 2010 Feb 2. J Hepatol. 2010. PMID: 20185198

Clinical course and predictive factors of virological response in long-term lamivudine plus adefovir dipivoxil combination therapy for lamivudine-resistant chronic hepatitis B patients.

Aizawa M, Tsubota A, Fujise K, Tatsuzawa K, Kono M, Hoshina S, Tajiri H. Aizawa M, et al. J Med Virol. 2011 Jun;83(6):953-61. doi: 10.1002/jmv.22025. J Med Virol. 2011. PMID: 21503906

Adefovir dipivoxil treatment of lamivudine-resistant chronic hepatitis B.

Dai CY, Chuang WL, Hsieh MY, Lee LP, Huang JF, Hou NJ, Lin ZY, Chen SC, Hsieh MY, Wang LY, Tsai JF, Chang WY, Yu ML. Dai CY, et al. Antiviral Res. 2007 Aug;75(2):146-51. doi: 10.1016/j.antiviral.2007.02.003. Epub 2007 Mar 16. Antiviral Res. 2007. PMID: 17400303 Clinical Trial.

Viral genotype and baseline load predict the response to adefovir treatment in lamivudine-resistant chronic hepatitis B patients.

Buti M, Elefsiniotis I, Jardi R, Vargas V, Rodriguez-Frias F, Schapper M, Bonovas S, Esteban R. Buti M, et al. J Hepatol. 2007 Sep;47(3):366-72. doi: 10.1016/j.jhep.2007.04.011. Epub 2007 May 24. J Hepatol. 2007. PMID: 17561304

Evolution of viral load and changes of polymerase and precore/core promoter sequences in lamivudine-resistant hepatitis B virus during adefovir therapy.

Chang UI, Lee YC, Wie SH, Jang JW, Bae SH, Choi JY, Yang JM, Yoon SK, Sun HS. Chang UI, et al. J Med Virol. 2007 Jul;79(7):902-10. doi: 10.1002/jmv.20819. J Med Virol. 2007. PMID: 17516533

A short course of add-on adefovir dipivoxil treatment in lamivudine-resistant chronic hepatitis B patients.

Idilman R, Kaymakoglu S, Oguz Onder F, Ahishali E, Bektas M, Cinar K, Pinarbasi B, Karayalcin S, Badur S, Cakaloglu Y, Mithat Bozdayi A, Bozkaya H, Okten A, Yurdaydin C. Idilman R, et al. J Viral Hepat. 2009 Apr;16(4):279-85. doi: 10.1111/j.1365-2893.2009.01074.x. Epub 2009 Feb 12. J Viral Hepat. 2009. PMID: 19222742

Lamivudine and adefovir resistance in children and young adults with chronic hepatitis B.

Akman SA, Kose S, Halicioglu O. Akman SA, et al. Int J Infect Dis. 2010 Mar;14(3):e236-9. doi: 10.1016/j.ijid.2009.04.002. Epub 2009 Aug 7. Int J Infect Dis. 2010. PMID: 19665408 Free article.

[The rate of hepatitis B virus resistance to adefovir dipivoxil (ADV) and the evolution of hepatitis B virus in lamivudine-resistant chronic hepatitis B patients with ADV monotherapy].

Qin YL, Zhang JM, Huang YX, Mao RC, Yin YK, Zhang WQ, Zhang QB, Wu XH, Weng XH. Qin YL, et al. Zhonghua Gan Zang Bing Za Zhi. 2007 Jan;15(1):4-7. Zhonghua Gan Zang Bing Za Zhi. 2007. PMID: 17244449 Chinese.

Adefovir and lamivudine in combination compared with adefovir monotherapy in HBeAg-negative adults with chronic hepatitis B virus infection and clinical or virologic resistance to lamivudine: a retrospective, multicenter, nonrandomized, open-label study.

Pellicelli AM, Barbaro G, Francavilla R, Romano M, Barbarini G, Mazzoni E, Mecenate F, Paffetti A, Barlattani A, Struglia C, Villani R, Nauri L, Nosotti L, Armignacco O, Ferri F, Camporiondo MP, Soccorsi F; Club Epatologi Ospedalieri (CLEO) Group. Pellicelli AM, et al. Clin Ther. 2008 Feb;30(2):317-23. doi: 10.1016/j.clinthera.2008.02.012. Clin Ther. 2008. PMID: 18343270

Adefovir plus lamivudine are more effective than adefovir alone in lamivudine-resistant HBeAg- chronic hepatitis B patients: a 4-year study.

Vassiliadis TG, Giouleme O, Koumerkeridis G, Koumaras H, Tziomalos K, Patsiaoura K, Grammatikos N, Mpoumponaris A, Gkisakis D, Theodoropoulos K, Panderi A, Katsinelos P, Eugenidis N. Vassiliadis TG, et al. J Gastroenterol Hepatol. 2010 Jan;25(1):54-60. doi: 10.1111/j.1440-1746.2009.05952.x. Epub 2009 Sep 22. J Gastroenterol Hepatol. 2010. PMID: 19780875 Clinical Trial.

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