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Items: 1 to 20 of 91

1.

Heterocyclic acetamide and benzamide derivatives as potent and selective beta3-adrenergic receptor agonists with improved rodent pharmacokinetic profiles.

Goble SD, Wang L, Howell KL, Bansal A, Berger R, Brockunier L, DiSalvo J, Feighner S, Harper B, He J, Hurley A, Hreniuk D, Parmee E, Robbins M, Salituro G, Sanfiz A, Streckfuss E, Watkins E, Weber AE, Struthers M, Edmondson SD.

Bioorg Med Chem Lett. 2010 Mar 15;20(6):1895-9. doi: 10.1016/j.bmcl.2010.01.130. Epub 2010 Feb 4.

PMID:
20181479
2.

Discovery of novel acetanilide derivatives as potent and selective beta3-adrenergic receptor agonists.

Maruyama T, Onda K, Hayakawa M, Matsui T, Takasu T, Ohta M.

Eur J Med Chem. 2009 Jun;44(6):2533-43. doi: 10.1016/j.ejmech.2009.01.022. Epub 2009 Jan 31.

PMID:
19232786
3.

Discovery of highly potent and selective biphenylacylsulfonamide-based beta3-adrenergic receptor agonists and evaluation of physical properties as potential overactive bladder therapies: part 5.

Hattori K, Toda S, Imanishi M, Itou S, Nakajima Y, Washizuka K, Araki T, Hamashima H, Tomishima Y, Sakurai M, Matsui S, Imamura E, Ueshima K, Yamamoto T, Yamamoto N, Ishikawa H, Nakano K, Unami N, Hamada K, Matsumura Y, Takamura F.

J Med Chem. 2009 May 14;52(9):3063-72. doi: 10.1021/jm9000709.

PMID:
19366244
4.

Discovery of a novel, potent and selective human beta3-adrenergic receptor agonist.

Nakajima Y, Hamashima H, Washizuka K, Tomishima Y, Ohtake H, Imamura E, Miura T, Kayakiri H, Kato M.

Bioorg Med Chem Lett. 2005 Jan 17;15(2):251-4.

PMID:
15603933
5.

Discovery of a novel series of biphenyl benzoic acid derivatives as highly potent and selective human beta3 adrenergic receptor agonists with good oral bioavailability. Part II.

Imanishi M, Itou S, Washizuka K, Hamashima H, Nakajima Y, Araki T, Tomishima Y, Sakurai M, Matsui S, Imamura E, Ueshima K, Yamamoto T, Yamamoto N, Ishikawa H, Nakano K, Unami N, Hamada K, Matsumura Y, Takamura F, Hattori K.

J Med Chem. 2008 Jul 10;51(13):4002-20. doi: 10.1021/jm8000345. Epub 2008 Jun 14.

PMID:
18553954
6.

Discovery of highly potent and selective biphenylacylsulfonamide-based beta3-adrenergic receptor agonists and molecular modeling based on the solved X-ray structure of the beta2-adrenergic receptor: part 6.

Hattori K, Orita M, Toda S, Imanishi M, Itou S, Nakajima Y, Tanabe D, Washizuka K, Araki T, Sakurai M, Matsui S, Imamura E, Ueshima K, Yamamoto T, Yamamoto N, Ishikawa H, Nakano K, Unami N, Hamada K, Matsumura Y, Takamura F.

Bioorg Med Chem Lett. 2009 Aug 15;19(16):4679-83. doi: 10.1016/j.bmcl.2009.06.083. Epub 2009 Jun 25.

PMID:
19608416
7.

Discovery of a novel and potent human and rat beta3-adrenergic receptor agonist, [3-[(2R)-[[(2R)-(3-chlorophenyl)-2-hydroxyethyl]amino]propyl]-1H-indol-7-yloxy]acetic acid.

Harada H, Hirokawa Y, Suzuki K, Hiyama Y, Oue M, Kawashima H, Kato H, Yoshida N, Furutani Y, Kato S.

Chem Pharm Bull (Tokyo). 2005 Feb;53(2):184-98.

8.

Discovery of a novel series of biphenyl benzoic acid derivatives as potent and selective human beta3-adrenergic receptor agonists with good oral bioavailability. Part I.

Imanishi M, Tomishima Y, Itou S, Hamashima H, Nakajima Y, Washizuka K, Sakurai M, Matsui S, Imamura E, Ueshima K, Yamamoto T, Yamamoto N, Ishikawa H, Nakano K, Unami N, Hamada K, Matsumura Y, Takamura F, Hattori K.

J Med Chem. 2008 Mar 27;51(6):1925-44. doi: 10.1021/jm701324c. Epub 2008 Feb 29.

PMID:
18307290
9.

Synthesis and evaluation of novel phenoxypropanolamine derivatives containing acetanilides as potent and selective beta3-adrenergic receptor agonists.

Maruyama T, Onda K, Hayakawa M, Seki N, Takahashi T, Moritomo H, Suzuki T, Matsui T, Takasu T, Nagase I, Ohta M.

Bioorg Med Chem. 2009 May 1;17(9):3283-94. doi: 10.1016/j.bmc.2009.03.044. Epub 2009 Mar 27.

PMID:
19362005
10.

Discovery of benzamides as potent human β3 adrenergic receptor agonists.

Zhu C, Kar NF, Li B, Costa M, Dingley KH, Di Salvo J, Ha SN, Hurley AL, Li X, Miller RR, Salituro GM, Struthers M, Weber AE, Hale JJ, Edmondson SD.

Bioorg Med Chem Lett. 2016 Jan 1;26(1):55-9. doi: 10.1016/j.bmcl.2015.11.030. Epub 2015 Nov 11.

PMID:
26590100
11.

Synthesis and evaluation of potent and selective beta3 adrenergic receptor agonists containing heterobiaryl carboxylic acids.

Shearer BG, Chao EY, Uehling DE, Deaton DN, Cowan C, Sherman BW, Milliken T, Faison W, Brown K, Adkison KK, Lee F.

Bioorg Med Chem Lett. 2007 Aug 15;17(16):4670-7. Epub 2007 May 25.

PMID:
17560786
12.

Discovery of novel series of benzoic acid derivatives containing biphenyl ether moiety as potent and selective human beta(3)-adrenergic receptor agonists: Part IV.

Nakajima Y, Imanishi M, Itou S, Hamashima H, Tomishima Y, Washizuka K, Sakurai M, Matsui S, Imamura E, Ueshima K, Yamamoto T, Yamamoto N, Ishikawa H, Nakano K, Unami N, Hamada K, Hattori K.

Bioorg Med Chem Lett. 2008 Sep 15;18(18):5037-40. doi: 10.1016/j.bmcl.2008.08.009. Epub 2008 Aug 7.

PMID:
18752946
13.

Tryptamine-based human beta3-adrenergic receptor agonists. Part 1: SAR studies of the 7-position of the indole ring.

Mizuno K, Sawa M, Harada H, Tateishi H, Oue M, Tsujiuchi H, Furutani Y, Kato S.

Bioorg Med Chem Lett. 2004 Dec 20;14(24):5959-62.

PMID:
15546707
14.

Recent developments in the design of orally bioavailable beta3-adrenergic receptor agonists.

Sawa M, Harada H.

Curr Med Chem. 2006;13(1):25-37. Review.

PMID:
16457637
15.

Discovery of potent and orally bioavailable heterocycle-based beta3-adrenergic receptor agonists, potential therapeutics for the treatment of obesity.

Lafontaine JA, Day RF, Dibrino J, Hadcock JR, Hargrove DM, Linhares M, Martin KA, Maurer TS, Nardone NA, Tess DA, Dasilva-Jardine P.

Bioorg Med Chem Lett. 2007 Sep 15;17(18):5245-50. Epub 2007 Jun 30.

PMID:
17632003
16.

Discovery of novel thiourea derivatives as potent and selective beta3-adrenergic receptor agonists.

Maruyama T, Seki N, Onda K, Suzuki T, Kawazoe S, Hayakawa M, Matsui T, Takasu T, Ohta M.

Bioorg Med Chem. 2009 Aug 1;17(15):5510-9. doi: 10.1016/j.bmc.2009.06.031. Epub 2009 Jun 21.

PMID:
19581100
17.

Potent and selective human beta(3)-adrenergic receptor antagonists.

Candelore MR, Deng L, Tota L, Guan XM, Amend A, Liu Y, Newbold R, Cascieri MA, Weber AE.

J Pharmacol Exp Ther. 1999 Aug;290(2):649-55.

18.

Discovery of 1,7-cyclized indoles as a new class of potent and highly selective human beta3-adrenergic receptor agonists with high cell permeability.

Mizuno K, Sawa M, Harada H, Taoka I, Yamashita H, Oue M, Tsujiuchi H, Arai Y, Suzuki S, Furutani Y, Kato S.

Bioorg Med Chem. 2005 Feb 1;13(3):855-68.

PMID:
15653351
19.

Novel substituted 4-aminomethylpiperidines as potent and selective human beta3-agonists. Part 1: aryloxypropanolaminomethylpiperidines.

Steffan RJ, Ashwell MA, Solvibile WR, Matelan E, Largis E, Han S, Tillet J, Mulvey R.

Bioorg Med Chem Lett. 2002 Oct 21;12(20):2957-61.

PMID:
12270183
20.

Synthesis and evaluation of N-phenyl-(2-aminothiazol-4-yl)acetamides with phenoxypropanolamine moiety as selective β3-adrenergic receptor agonists.

Maruyama T, Onda K, Suzuki T, Hayakawa M, Takahashi T, Matsui T, Takasu T, Nagase I, Ohta M.

Chem Pharm Bull (Tokyo). 2012;60(5):647-58.

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