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Lactate clearance vs central venous oxygen saturation as goals of early sepsis therapy: a randomized clinical trial.

Jones AE, Shapiro NI, Trzeciak S, Arnold RC, Claremont HA, Kline JA; Emergency Medicine Shock Research Network (EMShockNet) Investigators..

JAMA. 2010 Feb 24;303(8):739-46. doi: 10.1001/jama.2010.158.


Comprehensive Interpretation of Central Venous Oxygen Saturation and Blood Lactate Levels During Resuscitation of Patients With Severe Sepsis and Septic Shock in the Emergency Department.

Shin TG, Jo IJ, Hwang SY, Jeon K, Suh GY, Choe E, Lee YK, Lee TR, Cha WC, Sim MS.

Shock. 2016 Jan;45(1):4-9. doi: 10.1097/SHK.0000000000000466.


[Comparison of the effect of fluid resuscitation as guided either by lactate clearance rate or by central venous oxygen saturation in patients with sepsis].

Yu B, Tian HY, Hu ZJ, Zhao C, Liu LX, Zhang Y, Zhu GJ, Wang LT, Wu XH, Li J.

Zhonghua Wei Zhong Bing Ji Jiu Yi Xue. 2013 Oct;25(10):578-83. doi: 10.3760/cma.j.issn.2095-4352.2013.10.002. Chinese.


Therapeutic goal achievements during severe sepsis and septic shock resuscitation and their association with patients' outcomes.

Permpikul C, Sringam P, Tongyoo S.

J Med Assoc Thai. 2014 Mar;97 Suppl 3:S176-83.


Central venous-to-arterial carbon dioxide partial pressure difference in early resuscitation from septic shock: a prospective observational study.

Mallat J, Pepy F, Lemyze M, Gasan G, Vangrunderbeeck N, Tronchon L, Vallet B, Thevenin D.

Eur J Anaesthesiol. 2014 Jul;31(7):371-80. doi: 10.1097/EJA.0000000000000064.


Prognostic value and agreement of achieving lactate clearance or central venous oxygen saturation goals during early sepsis resuscitation.

Puskarich MA, Trzeciak S, Shapiro NI, Arnold RC, Heffner AC, Kline JA, Jones AE; Emergency Medicine Shock Research Network (EMSHOCKNET)..

Acad Emerg Med. 2012 Mar;19(3):252-8. doi: 10.1111/j.1553-2712.2012.01292.x.


Prognostic Value of Lactate and Central Venous Oxygen Saturation after Early Resuscitation in Sepsis Patients.

Lee YK, Hwang SY, Shin TG, Jo IJ, Suh GY, Jeon K.

PLoS One. 2016 Apr 7;11(4):e0153305. doi: 10.1371/journal.pone.0153305. eCollection 2016. Erratum in: PLoS One. 2016;11(6):e0157225.


Early goal-directed therapy in the treatment of severe sepsis and septic shock.

Rivers E, Nguyen B, Havstad S, Ressler J, Muzzin A, Knoblich B, Peterson E, Tomlanovich M; Early Goal-Directed Therapy Collaborative Group..

N Engl J Med. 2001 Nov 8;345(19):1368-77.


Combining central venous-to-arterial partial pressure of carbon dioxide difference and central venous oxygen saturation to guide resuscitation in septic shock.

Du W, Liu DW, Wang XT, Long Y, Chai WZ, Zhou X, Rui X.

J Crit Care. 2013 Dec;28(6):1110.e1-5. doi: 10.1016/j.jcrc.2013.07.049.


Early lactate clearance is associated with improved outcome in severe sepsis and septic shock.

Nguyen HB, Rivers EP, Knoblich BP, Jacobsen G, Muzzin A, Ressler JA, Tomlanovich MC.

Crit Care Med. 2004 Aug;32(8):1637-42.


Dynamics of central venous oxygen saturation and serum lactate during septic shock resuscitation.

Permpikul C, Noppakaorattanamanee K, Tongyoo S, Ratanarat R, Poompichet A.

J Med Assoc Thai. 2013 Feb;96 Suppl 2:S232-7.


[Combination of central venous-to-arterial PCO2 difference with central venous oxygen saturation to guide the shock resuscitation].

DU W, Liu DW, Long Y, Wang XT, Chai WZ, Zhou X, Rui X.

Zhonghua Yi Xue Za Zhi. 2012 Apr 3;92(13):909-14. Chinese.


A randomized trial of protocol-based care for early septic shock.

ProCESS Investigators., Yealy DM, Kellum JA, Huang DT, Barnato AE, Weissfeld LA, Pike F, Terndrup T, Wang HE, Hou PC, LoVecchio F, Filbin MR, Shapiro NI, Angus DC.

N Engl J Med. 2014 May 1;370(18):1683-93. doi: 10.1056/NEJMoa1401602. Epub 2014 Mar 18.


Prevalence of low central venous oxygen saturation in the first hours of intensive care unit admission and associated mortality in septic shock patients: a prospective multicentre study.

Boulain T, Garot D, Vignon P, Lascarrou JB, Desachy A, Botoc V, Follin A, Frat JP, Bellec F, Quenot JP, Mathonnet A, Dequin PF; Clinical Research in Intensive Care and Sepsis Group..

Crit Care. 2014 Nov 6;18(6):609. doi: 10.1186/s13054-014-0609-7.


Central venous oxygen saturation under non-protocolized resuscitation is not related to survival in severe sepsis or septic shock.

Chung KP, Chang HT, Huang YT, Liao CH, Ho CC, Jerng JS, Yu CJ.

Shock. 2012 Dec;38(6):584-91. doi: 10.1097/SHK.0b013e318274c674.


Early goal-directed therapy in pediatric septic shock: comparison of outcomes "with" and "without" intermittent superior venacaval oxygen saturation monitoring: a prospective cohort study*.

Sankar J, Sankar MJ, Suresh CP, Dubey NK, Singh A.

Pediatr Crit Care Med. 2014 May;15(4):e157-67. doi: 10.1097/PCC.0000000000000073.


[Improvement effect of early goal-directed therapy on the prognosis in patients with septic shock].

Li C, Yun D.

Zhonghua Wei Zhong Bing Ji Jiu Yi Xue. 2015 Nov;27(11):899-905. Chinese.


Implementation of a bundle of quality indicators for the early management of severe sepsis and septic shock is associated with decreased mortality.

Nguyen HB, Corbett SW, Steele R, Banta J, Clark RT, Hayes SR, Edwards J, Cho TW, Wittlake WA.

Crit Care Med. 2007 Apr;35(4):1105-12.


Multicenter study of early lactate clearance as a determinant of survival in patients with presumed sepsis.

Arnold RC, Shapiro NI, Jones AE, Schorr C, Pope J, Casner E, Parrillo JE, Dellinger RP, Trzeciak S; Emergency Medicine Shock Research Network (EMShockNet) Investigators..

Shock. 2009 Jul;32(1):35-9.


Association of left ventricular longitudinal strain with central venous oxygen saturation and serum lactate in patients with early severe sepsis and septic shock.

Lanspa MJ, Pittman JE, Hirshberg EL, Wilson EL, Olsen T, Brown SM, Grissom CK.

Crit Care. 2015 Aug 31;19:304. doi: 10.1186/s13054-015-1014-6.

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