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Items: 1 to 20 of 101


Calcium-dependent conformational flexibility of a CUB domain controls activation of the complement serine protease C1r.

Major B, Kardos J, Kékesi KA, Lorincz Z, Závodszky P, Gál P.

J Biol Chem. 2010 Apr 16;285(16):11863-9. doi: 10.1074/jbc.M109.098541. Epub 2010 Feb 23.


Intermodule cooperativity in the structure and dynamics of consecutive complement control modules in human C1r: structural biology.

Láng A, Szilágyi K, Major B, Gál P, Závodszky P, Perczel A.

FEBS J. 2010 Oct;277(19):3986-98. doi: 10.1111/j.1742-4658.2010.07790.x. Epub 2010 Aug 26.


Identification of the C1q-binding Sites of Human C1r and C1s: a refined three-dimensional model of the C1 complex of complement.

Bally I, Rossi V, Lunardi T, Thielens NM, Gaboriaud C, Arlaud GJ.

J Biol Chem. 2009 Jul 17;284(29):19340-8. doi: 10.1074/jbc.M109.004473. Epub 2009 May 27.


Structure and function of the serine-protease subcomponents of C1: protein engineering studies.

Gál P, Závodszky P.

Immunobiology. 1998 Aug;199(2):317-26. Review.


Expression of recombinant human complement C1q allows identification of the C1r/C1s-binding sites.

Bally I, Ancelet S, Moriscot C, Gonnet F, Mantovani A, Daniel R, Schoehn G, Arlaud GJ, Thielens NM.

Proc Natl Acad Sci U S A. 2013 May 21;110(21):8650-5. doi: 10.1073/pnas.1304894110. Epub 2013 May 6.


The N-terminal CUB-epidermal growth factor module pair of human complement protease C1r binds Ca2+ with high affinity and mediates Ca2+-dependent interaction with C1s.

Thielens NM, Enrie K, Lacroix M, Jaquinod M, Hernandez JF, Esser AF, Arlaud GJ.

J Biol Chem. 1999 Apr 2;274(14):9149-59.


The role of the individual domains in the structure and function of the catalytic region of a modular serine protease, C1r.

Kardos J, Gál P, Szilágyi L, Thielens NM, Szilágyi K, Lõrincz Z, Kulcsár P, Gráf L, Arlaud GJ, Závodszky P.

J Immunol. 2001 Nov 1;167(9):5202-8.


The structure and function of the first component of complement: genetic engineering approach (a review).

Gál P, Cseh S, Schumaker VN, Závodszky P.

Acta Microbiol Immunol Hung. 1994;41(4):361-80. Review.


Monomeric structures of the zymogen and active catalytic domain of complement protease c1r: further insights into the c1 activation mechanism.

Budayova-Spano M, Grabarse W, Thielens NM, Hillen H, Lacroix M, Schmidt M, Fontecilla-Camps JC, Arlaud GJ, Gaboriaud C.

Structure. 2002 Nov;10(11):1509-19.


Assembly and enzymatic properties of the catalytic domain of human complement protease C1r.

Lacroix M, Ebel C, Kardos J, Dobó J, Gál P, Závodszky P, Arlaud GJ, Thielens NM.

J Biol Chem. 2001 Sep 28;276(39):36233-40. Epub 2001 Jul 9.


Chemical synthesis and characterization of the epidermal growth factor-like module of human complement protease C1r.

Hernandez JF, Bersch B, Pétillot Y, Gagnon J, Arlaud GJ.

J Pept Res. 1997 Mar;49(3):221-31.


Mapping surface accessibility of the C1r/C1s tetramer by chemical modification and mass spectrometry provides new insights into assembly of the human C1 complex.

Brier S, Pflieger D, Le Mignon M, Bally I, Gaboriaud C, Arlaud GJ, Daniel R.

J Biol Chem. 2010 Oct 15;285(42):32251-63. doi: 10.1074/jbc.M110.149112. Epub 2010 Jun 30.


Revisiting the mechanism of the autoactivation of the complement protease C1r in the C1 complex: structure of the active catalytic region of C1r.

Kardos J, Harmat V, Palló A, Barabás O, Szilágyi K, Gráf L, Náray-Szabó G, Goto Y, Závodszky P, Gál P.

Mol Immunol. 2008 Mar;45(6):1752-60. Epub 2007 Nov 9.


The cleavage of two C1s subunits by a single active C1r reveals substantial flexibility of the C1s-C1r-C1r-C1s tetramer in the C1 complex.

Lörincz Z, Gál P, Dobó J, Cseh S, Szilágyi K, Ambrus G, Závodszky P.

J Immunol. 2000 Aug 15;165(4):2048-51.


Molecular determinants of the substrate specificity of the complement-initiating protease, C1r.

Wijeyewickrema LC, Yongqing T, Tran TP, Thompson PE, Viljoen JE, Coetzer TH, Duncan RC, Kass I, Buckle AM, Pike RN.

J Biol Chem. 2013 May 31;288(22):15571-80. doi: 10.1074/jbc.M113.451757. Epub 2013 Apr 15.


X-ray structure of the Ca2+-binding interaction domain of C1s. Insights into the assembly of the C1 complex of complement.

Gregory LA, Thielens NM, Arlaud GJ, Fontecilla-Camps JC, Gaboriaud C.

J Biol Chem. 2003 Aug 22;278(34):32157-64. Epub 2003 Jun 4.


Structure and functions of the interaction domains of C1r and C1s: keystones of the architecture of the C1 complex.

Thielens NM, Bersch B, Hernandez JF, Arlaud GJ.

Immunopharmacology. 1999 May;42(1-3):3-13. Review.


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