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Items: 1 to 20 of 130

1.

A polycystin-2 (TRPP2) dimerization domain essential for the function of heteromeric polycystin complexes.

Giamarchi A, Feng S, Rodat-Despoix L, Xu Y, Bubenshchikova E, Newby LJ, Hao J, Gaudioso C, Crest M, Lupas AN, Honoré E, Williamson MP, Obara T, Ong AC, Delmas P.

EMBO J. 2010 Apr 7;29(7):1176-91. doi: 10.1038/emboj.2010.18. Epub 2010 Feb 18.

2.

A single amino acid residue constitutes the third dimerization domain essential for the assembly and function of the tetrameric polycystin-2 (TRPP2) channel.

Feng S, Rodat-Despoix L, Delmas P, Ong AC.

J Biol Chem. 2011 May 27;286(21):18994-9000. doi: 10.1074/jbc.M110.192286. Epub 2011 Apr 7.

3.

Polycystin-1 maturation requires polycystin-2 in a dose-dependent manner.

Gainullin VG, Hopp K, Ward CJ, Hommerding CJ, Harris PC.

J Clin Invest. 2015 Feb;125(2):607-20. doi: 10.1172/JCI76972. Epub 2015 Jan 9.

4.

Identification and functional characterization of an N-terminal oligomerization domain for polycystin-2.

Feng S, Okenka GM, Bai CX, Streets AJ, Newby LJ, DeChant BT, Tsiokas L, Obara T, Ong AC.

J Biol Chem. 2008 Oct 17;283(42):28471-9. doi: 10.1074/jbc.M803834200. Epub 2008 Aug 13.

5.

Human ADPKD primary cyst epithelial cells with a novel, single codon deletion in the PKD1 gene exhibit defective ciliary polycystin localization and loss of flow-induced Ca2+ signaling.

Xu C, Rossetti S, Jiang L, Harris PC, Brown-Glaberman U, Wandinger-Ness A, Bacallao R, Alper SL.

Am J Physiol Renal Physiol. 2007 Mar;292(3):F930-45. Epub 2006 Nov 7.

6.

Analysis of the cytoplasmic interaction between polycystin-1 and polycystin-2.

Casuscelli J, Schmidt S, DeGray B, Petri ET, Celić A, Folta-Stogniew E, Ehrlich BE, Boggon TJ.

Am J Physiol Renal Physiol. 2009 Nov;297(5):F1310-5. doi: 10.1152/ajprenal.00412.2009. Epub 2009 Sep 2.

7.

Polycystin-1 negatively regulates Polycystin-2 expression via the aggresome/autophagosome pathway.

Cebotaru V, Cebotaru L, Kim H, Chiaravalli M, Boletta A, Qian F, Guggino WB.

J Biol Chem. 2014 Mar 7;289(10):6404-14. doi: 10.1074/jbc.M113.501205. Epub 2014 Jan 23.

8.

Polycystin-1 surface localization is stimulated by polycystin-2 and cleavage at the G protein-coupled receptor proteolytic site.

Chapin HC, Rajendran V, Caplan MJ.

Mol Biol Cell. 2010 Dec;21(24):4338-48. doi: 10.1091/mbc.E10-05-0407. Epub 2010 Oct 27.

9.

Polycystin-2 induces a conformational change in polycystin-1.

Oatley P, Talukder MM, Stewart AP, Sandford R, Edwardson JM.

Biochemistry. 2013 Aug 6;52(31):5280-7. doi: 10.1021/bi400233e. Epub 2013 Jul 24.

PMID:
23848298
10.

Identification of a polycystin-1 cleavage product, P100, that regulates store operated Ca entry through interactions with STIM1.

Woodward OM, Li Y, Yu S, Greenwell P, Wodarczyk C, Boletta A, Guggino WB, Qian F.

PLoS One. 2010 Aug 23;5(8):e12305. doi: 10.1371/journal.pone.0012305.

11.

Extracellular Loops Are Essential for the Assembly and Function of Polycystin Receptor-Ion Channel Complexes.

Salehi-Najafabadi Z, Li B, Valentino V, Ng C, Martin H, Yu Y, Wang Z, Kashyap P, Yu Y.

J Biol Chem. 2017 Mar 10;292(10):4210-4221. doi: 10.1074/jbc.M116.767897. Epub 2017 Feb 2.

PMID:
28154010
12.

Reduced ciliary polycystin-2 in induced pluripotent stem cells from polycystic kidney disease patients with PKD1 mutations.

Freedman BS, Lam AQ, Sundsbak JL, Iatrino R, Su X, Koon SJ, Wu M, Daheron L, Harris PC, Zhou J, Bonventre JV.

J Am Soc Nephrol. 2013 Oct;24(10):1571-86. doi: 10.1681/ASN.2012111089. Epub 2013 Sep 5.

13.

Hyperphosphorylation of polycystin-2 at a critical residue in disease reveals an essential role for polycystin-1-regulated dephosphorylation.

Streets AJ, Wessely O, Peters DJ, Ong AC.

Hum Mol Genet. 2013 May 15;22(10):1924-39. doi: 10.1093/hmg/ddt031. Epub 2013 Feb 5.

14.
15.

Expression of the polycystin-1 C-terminal cytoplasmic tail increases Cl channel activity in Xenopus oocytes.

Chernova MN, Vandorpe DH, Clark JS, Alper SL.

Kidney Int. 2005 Aug;68(2):632-41.

16.

Polycystin-2 mutations lead to impaired calcium cycling in the heart and predispose to dilated cardiomyopathy.

Paavola J, Schliffke S, Rossetti S, Kuo IY, Yuan S, Sun Z, Harris PC, Torres VE, Ehrlich BE.

J Mol Cell Cardiol. 2013 May;58:199-208. doi: 10.1016/j.yjmcc.2013.01.015. Epub 2013 Jan 30.

17.

Regulation of polycystin-1 ciliary trafficking by motifs at its C-terminus and polycystin-2 but not by cleavage at the GPS site.

Su X, Wu M, Yao G, El-Jouni W, Luo C, Tabari A, Zhou J.

J Cell Sci. 2015 Nov 15;128(22):4063-73. doi: 10.1242/jcs.160556. Epub 2015 Oct 1.

18.

Deficiency of polycystin-2 reduces Ca2+ channel activity and cell proliferation in ADPKD lymphoblastoid cells.

Aguiari G, Banzi M, Gessi S, Cai Y, Zeggio E, Manzati E, Piva R, Lambertini E, Ferrari L, Peters DJ, Lanza F, Harris PC, Borea PA, Somlo S, Del Senno L.

FASEB J. 2004 May;18(7):884-6. Epub 2004 Mar 4.

PMID:
15001556
19.

Genetic Mechanisms of ADPKD.

Kim DY, Park JH.

Adv Exp Med Biol. 2016;933:13-22. Review.

PMID:
27730431
20.

A short carboxy-terminal domain of polycystin-1 reorganizes the microtubular network and the endoplasmic reticulum.

Gao H, Sellin LK, Pütz M, Nickel C, Imgrund M, Gerke P, Nitschke R, Walz G, Kramer-Zucker AG.

Exp Cell Res. 2009 Apr 15;315(7):1157-70. doi: 10.1016/j.yexcr.2009.01.027. Epub 2009 Feb 10.

PMID:
19331813

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