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Diet and exercise signals regulate SIRT3 and activate AMPK and PGC-1alpha in skeletal muscle.

Palacios OM, Carmona JJ, Michan S, Chen KY, Manabe Y, Ward JL 3rd, Goodyear LJ, Tong Q.

Aging (Albany NY). 2009 Aug 15;1(9):771-83.


Effect of lifelong resveratrol supplementation and exercise training on skeletal muscle oxidative capacity in aging mice; impact of PGC-1α.

Ringholm S, Olesen J, Pedersen JT, Brandt CT, Halling JF, Hellsten Y, Prats C, Pilegaard H.

Exp Gerontol. 2013 Nov;48(11):1311-8. doi: 10.1016/j.exger.2013.08.012. Epub 2013 Aug 29.


Energy-sensing factors coactivator peroxisome proliferator-activated receptor γ coactivator 1-α (PGC-1α) and AMP-activated protein kinase control expression of inflammatory mediators in liver: induction of interleukin 1 receptor antagonist.

Buler M, Aatsinki SM, Skoumal R, Komka Z, Tóth M, Kerkelä R, Georgiadi A, Kersten S, Hakkola J.

J Biol Chem. 2012 Jan 13;287(3):1847-60. doi: 10.1074/jbc.M111.302356. Epub 2011 Nov 23.


PGC-1alpha is not mandatory for exercise- and training-induced adaptive gene responses in mouse skeletal muscle.

Leick L, Wojtaszewski JF, Johansen ST, Kiilerich K, Comes G, Hellsten Y, Hidalgo J, Pilegaard H.

Am J Physiol Endocrinol Metab. 2008 Feb;294(2):E463-74. Epub 2007 Dec 11.


Interdependence of AMPK and SIRT1 for metabolic adaptation to fasting and exercise in skeletal muscle.

Cantó C, Jiang LQ, Deshmukh AS, Mataki C, Coste A, Lagouge M, Zierath JR, Auwerx J.

Cell Metab. 2010 Mar 3;11(3):213-9. doi: 10.1016/j.cmet.2010.02.006.


Mitochondrial biogenesis and PGC-1α deacetylation by chronic treadmill exercise: differential response in cardiac and skeletal muscle.

Li L, Mühlfeld C, Niemann B, Pan R, Li R, Hilfiker-Kleiner D, Chen Y, Rohrbach S.

Basic Res Cardiol. 2011 Nov;106(6):1221-34. doi: 10.1007/s00395-011-0213-9. Epub 2011 Aug 28.


Sirtuin 3, a new target of PGC-1alpha, plays an important role in the suppression of ROS and mitochondrial biogenesis.

Kong X, Wang R, Xue Y, Liu X, Zhang H, Chen Y, Fang F, Chang Y.

PLoS One. 2010 Jul 22;5(7):e11707. doi: 10.1371/journal.pone.0011707.


Sirtuin 1 (SIRT1) deacetylase activity is not required for mitochondrial biogenesis or peroxisome proliferator-activated receptor-gamma coactivator-1alpha (PGC-1alpha) deacetylation following endurance exercise.

Philp A, Chen A, Lan D, Meyer GA, Murphy AN, Knapp AE, Olfert IM, McCurdy CE, Marcotte GR, Hogan MC, Baar K, Schenk S.

J Biol Chem. 2011 Sep 2;286(35):30561-70. doi: 10.1074/jbc.M111.261685. Epub 2011 Jul 11.


An increase in murine skeletal muscle peroxisome proliferator-activated receptor-gamma coactivator-1alpha (PGC-1alpha) mRNA in response to exercise is mediated by beta-adrenergic receptor activation.

Miura S, Kawanaka K, Kai Y, Tamura M, Goto M, Shiuchi T, Minokoshi Y, Ezaki O.

Endocrinology. 2007 Jul;148(7):3441-8. Epub 2007 Apr 19.


Effect of Exercise Training on Skeletal Muscle SIRT1 and PGC-1α Expression Levels in Rats of Different Age.

Huang CC, Wang T, Tung YT, Lin WT.

Int J Med Sci. 2016 Mar 16;13(4):260-70. doi: 10.7150/ijms.14586. eCollection 2016.


Exercise training attenuates aging-associated mitochondrial dysfunction in rat skeletal muscle: role of PGC-1α.

Kang C, Chung E, Diffee G, Ji LL.

Exp Gerontol. 2013 Nov;48(11):1343-50. doi: 10.1016/j.exger.2013.08.004. Epub 2013 Aug 30.


Effect of exercise intensity and AICAR on isoform-specific expressions of murine skeletal muscle PGC-1α mRNA: a role of β₂-adrenergic receptor activation.

Tadaishi M, Miura S, Kai Y, Kawasaki E, Koshinaka K, Kawanaka K, Nagata J, Oishi Y, Ezaki O.

Am J Physiol Endocrinol Metab. 2011 Feb;300(2):E341-9. doi: 10.1152/ajpendo.00400.2010. Epub 2010 Nov 23.


Effects of alpha-AMPK knockout on exercise-induced gene activation in mouse skeletal muscle.

Jørgensen SB, Wojtaszewski JF, Viollet B, Andreelli F, Birk JB, Hellsten Y, Schjerling P, Vaulont S, Neufer PD, Richter EA, Pilegaard H.

FASEB J. 2005 Jul;19(9):1146-8. Epub 2005 May 5.


Mitochondrial biogenesis and peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α) deacetylation by physical activity: intact adipocytokine signaling is required.

Li L, Pan R, Li R, Niemann B, Aurich AC, Chen Y, Rohrbach S.

Diabetes. 2011 Jan;60(1):157-67. doi: 10.2337/db10-0331. Epub 2010 Oct 7.


AMP-activated protein kinase is required for exercise-induced peroxisome proliferator-activated receptor co-activator 1 translocation to subsarcolemmal mitochondria in skeletal muscle.

Smith BK, Mukai K, Lally JS, Maher AC, Gurd BJ, Heigenhauser GJ, Spriet LL, Holloway GP.

J Physiol. 2013 Mar 15;591(6):1551-61. doi: 10.1113/jphysiol.2012.245944. Epub 2013 Jan 7.


PGC-1alpha mediates exercise-induced skeletal muscle VEGF expression in mice.

Leick L, Hellsten Y, Fentz J, Lyngby SS, Wojtaszewski JF, Hidalgo J, Pilegaard H.

Am J Physiol Endocrinol Metab. 2009 Jul;297(1):E92-103. doi: 10.1152/ajpendo.00076.2009. Epub 2009 Apr 28.


NOS isoform-specific regulation of basal but not exercise-induced mitochondrial biogenesis in mouse skeletal muscle.

Wadley GD, Choate J, McConell GK.

J Physiol. 2007 Nov 15;585(Pt 1):253-62. Epub 2007 Oct 4.


Dihydromyricetin improves skeletal muscle insulin sensitivity by inducing autophagy via the AMPK-PGC-1α-Sirt3 signaling pathway.

Shi L, Zhang T, Zhou Y, Zeng X, Ran L, Zhang Q, Zhu J, Mi M.

Endocrine. 2015 Nov;50(2):378-89. doi: 10.1007/s12020-015-0599-5. Epub 2015 Apr 21.


Endurance exercise increases the SIRT1 and peroxisome proliferator-activated receptor gamma coactivator-1alpha protein expressions in rat skeletal muscle.

Suwa M, Nakano H, Radak Z, Kumagai S.

Metabolism. 2008 Jul;57(7):986-98. doi: 10.1016/j.metabol.2008.02.017.


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