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Telomere length regulates ISG15 expression in human cells.

Lou Z, Wei J, Riethman H, Baur JA, Voglauer R, Shay JW, Wright WE.

Aging (Albany NY). 2009 Jul 17;1(7):608-21.


Homocysteine accelerates senescence of endothelial cells via DNA hypomethylation of human telomerase reverse transcriptase.

Zhang D, Sun X, Liu J, Xie X, Cui W, Zhu Y.

Arterioscler Thromb Vasc Biol. 2015 Jan;35(1):71-8. doi: 10.1161/ATVBAHA.114.303899. Epub 2014 Oct 30.


Human telomerase reverse transcriptase immortalizes bovine lens epithelial cells and suppresses differentiation through regulation of the ERK signaling pathway.

Wang J, Feng H, Huang XQ, Xiang H, Mao YW, Liu JP, Yan Q, Liu WB, Liu Y, Deng M, Gong L, Sun S, Luo C, Liu SJ, Zhang XJ, Liu Y, Li DW.

J Biol Chem. 2005 Jun 17;280(24):22776-87. Epub 2005 Apr 22.


Telomere-independent cellular senescence in human fetal cardiomyocytes.

Ball AJ, Levine F.

Aging Cell. 2005 Feb;4(1):21-30.


Age-related telomere uncapping is associated with cellular senescence and inflammation independent of telomere shortening in human arteries.

Morgan RG, Ives SJ, Lesniewski LA, Cawthon RM, Andtbacka RH, Noyes RD, Richardson RS, Donato AJ.

Am J Physiol Heart Circ Physiol. 2013 Jul 15;305(2):H251-8. doi: 10.1152/ajpheart.00197.2013. Epub 2013 May 10.


Telomere-based proliferative lifespan barriers in Werner-syndrome fibroblasts involve both p53-dependent and p53-independent mechanisms.

Davis T, Singhrao SK, Wyllie FS, Haughton MF, Smith PJ, Wiltshire M, Wynford-Thomas D, Jones CJ, Faragher RG, Kipling D.

J Cell Sci. 2003 Apr 1;116(Pt 7):1349-57.


Stress-induced premature senescence in BJ and hTERT-BJ1 human foreskin fibroblasts.

de Magalhães JP, Chainiaux F, Remacle J, Toussaint O.

FEBS Lett. 2002 Jul 17;523(1-3):157-62.


In vitro lifespan and senescence mechanisms of human nucleus pulposus chondrocytes.

Jeong SW, Lee JS, Kim KW.

Spine J. 2014 Mar 1;14(3):499-504. doi: 10.1016/j.spinee.2013.06.099. Epub 2013 Dec 15.


Events in the immortalizing process of primary human mammary epithelial cells by the catalytic subunit of human telomerase.

Kim H, Farris J, Christman SA, Kong BW, Foster LK, O'Grady SM, Foster DN.

Biochem J. 2002 Aug 1;365(Pt 3):765-72.


Smurf2 up-regulation activates telomere-dependent senescence.

Zhang H, Cohen SN.

Genes Dev. 2004 Dec 15;18(24):3028-40. Epub 2004 Dec 1.


DNA damage checkpoint kinase Chk2 triggers replicative senescence.

Gire V, Roux P, Wynford-Thomas D, Brondello JM, Dulic V.

EMBO J. 2004 Jul 7;23(13):2554-63. Epub 2004 Jun 10.


Bypass of telomere-dependent replicative senescence (M1) upon overexpression of Cdk4 in normal human epithelial cells.

Ramirez RD, Herbert BS, Vaughan MB, Zou Y, Gandia K, Morales CP, Wright WE, Shay JW.

Oncogene. 2003 Jan 23;22(3):433-44.


Deletion of the Isg15 gene results in up-regulation of decidual cell survival genes and down-regulation of adhesion genes: implication for regulation by IL-1beta.

Ashley RL, Henkes LE, Bouma GJ, Pru JK, Hansen TR.

Endocrinology. 2010 Sep;151(9):4527-36. doi: 10.1210/en.2010-0166. Epub 2010 Jul 21.


Bone morphogenetic protein-7 induces telomerase inhibition, telomere shortening, breast cancer cell senescence, and death via Smad3.

Cassar L, Nicholls C, Pinto AR, Li H, Liu JP.

FASEB J. 2009 Jun;23(6):1880-92. doi: 10.1096/fj.08-119529. Epub 2009 Feb 4. Retraction in: FASEB J. 2009 Aug;23(8):2790.


Postmitotic neurons develop a p21-dependent senescence-like phenotype driven by a DNA damage response.

Jurk D, Wang C, Miwa S, Maddick M, Korolchuk V, Tsolou A, Gonos ES, Thrasivoulou C, Saffrey MJ, Cameron K, von Zglinicki T.

Aging Cell. 2012 Dec;11(6):996-1004. doi: 10.1111/j.1474-9726.2012.00870.x. Epub 2012 Sep 12.


Telomere position effect: regulation of gene expression with progressive telomere shortening over long distances.

Robin JD, Ludlow AT, Batten K, Magdinier F, Stadler G, Wagner KR, Shay JW, Wright WE.

Genes Dev. 2014 Nov 15;28(22):2464-76. doi: 10.1101/gad.251041.114.


p53-Dependent accelerated senescence induced by ionizing radiation in breast tumour cells.

Jones KR, Elmore LW, Jackson-Cook C, Demasters G, Povirk LF, Holt SE, Gewirtz DA.

Int J Radiat Biol. 2005 Jun;81(6):445-58.


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