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Items: 1 to 20 of 92

1.

Diverted total synthesis leads to the generation of promising cell-migration inhibitors for treatment of tumor metastasis: in vivo and mechanistic studies on the migrastatin core ether analog.

Oskarsson T, Nagorny P, Krauss IJ, Perez L, Mandal M, Yang G, Ouerfelli O, Xiao D, Moore MA, Massagué J, Danishefsky SJ.

J Am Chem Soc. 2010 Mar 10;132(9):3224-8. doi: 10.1021/ja9101503.

2.

The Therapeutic Potential of Migrastatin-Core Analogs for the Treatment of Metastatic Cancer.

Giralt E, Lo Re D.

Molecules. 2017 Feb 9;22(2). pii: E198. doi: 10.3390/molecules22020198. Review.

3.

Migrastatin analogues target fascin to block tumour metastasis.

Chen L, Yang S, Jakoncic J, Zhang JJ, Huang XY.

Nature. 2010 Apr 15;464(7291):1062-6. doi: 10.1038/nature08978. Erratum in: Nature. 2011 Aug 11;476(7359):240.

4.

Emergence of potent inhibitors of metastasis in lung cancer via syntheses based on migrastatin.

Lecomte N, Njardarson JT, Nagorny P, Yang G, Downey R, Ouerfelli O, Moore MA, Danishefsky SJ.

Proc Natl Acad Sci U S A. 2011 Sep 13;108(37):15074-8. doi: 10.1073/pnas.1015247108. Epub 2011 Aug 1.

5.

Quantitative structure-activity studies on a series of migrastatin analogs as inhibitors of cancer cell metastasis.

Santos RN, Guido RV, Oliva G, Dias LC, Andricopulo AD.

Med Chem. 2011 May;7(3):155-64. doi: 1573-4064/11 $58.00+.00.

PMID:
21486209
6.

Synthetic macrolides that inhibit breast cancer cell migration in vitro.

Metaferia BB, Chen L, Baker HL, Huang XY, Bewley CA.

J Am Chem Soc. 2007 Mar 7;129(9):2434-5. Epub 2007 Feb 13. No abstract available.

PMID:
17295491
7.

Lactimidomycin, iso-migrastatin and related glutarimide-containing 12-membered macrolides are extremely potent inhibitors of cell migration.

Ju J, Rajski SR, Lim SK, Seo JW, Peters NR, Hoffmann FM, Shen B.

J Am Chem Soc. 2009 Feb 4;131(4):1370-1. doi: 10.1021/ja808462p.

8.

Synthetic analogues of migrastatin that inhibit mammary tumor metastasis in mice.

Shan D, Chen L, Njardarson JT, Gaul C, Ma X, Danishefsky SJ, Huang XY.

Proc Natl Acad Sci U S A. 2005 Mar 8;102(10):3772-6. Epub 2005 Feb 22.

9.

Multifaceted modes of action for the glutarimide-containing polyketides revealed.

Rajski SR, Shen B.

Chembiochem. 2010 Sep 24;11(14):1951-4. doi: 10.1002/cbic.201000370. No abstract available.

10.

Synthesis of migrastatin and its macroketone analogue and in vivo FRAP analysis of the macroketone on E-cadherin dynamics.

Lo Re D, Zhou Y, Nobis M, Anderson KI, Murphy PV.

Chembiochem. 2014 Jul 7;15(10):1459-64. doi: 10.1002/cbic.201402061. Epub 2014 Jun 11.

PMID:
24919421
11.

Migrastatin analogues inhibit canine mammary cancer cell migration and invasion.

Majchrzak K, Lo Re D, Gajewska M, Bulkowska M, Homa A, Pawłowski K, Motyl T, Murphy PV, Król M.

PLoS One. 2013 Oct 8;8(10):e76789. doi: 10.1371/journal.pone.0076789. eCollection 2013.

12.

Evaluation of new migrastatin and dorrigocin congeners unveils cell migration inhibitors with dramatically improved potency.

Ju J, Rajski SR, Lim SK, Seo JW, Peters NR, Hoffmann FM, Shen B.

Bioorg Med Chem Lett. 2008 Nov 15;18(22):5951-4. doi: 10.1016/j.bmcl.2008.07.072. Epub 2008 Jul 24.

13.

Discovery of potent cell migration inhibitors through total synthesis: lessons from structure-activity studies of (+)-migrastatin.

Njardarson JT, Gaul C, Shan D, Huang XY, Danishefsky SJ.

J Am Chem Soc. 2004 Feb 4;126(4):1038-40.

PMID:
14746469
14.

The migrastatin family: discovery of potent cell migration inhibitors by chemical synthesis.

Gaul C, Njardarson JT, Shan D, Dorn DC, Wu KD, Tong WP, Huang XY, Moore MA, Danishefsky SJ.

J Am Chem Soc. 2004 Sep 15;126(36):11326-37.

PMID:
15355116
15.

Migrastatin, a new inhibitor of tumor cell migration from Streptomyces sp. MK929-43F1. Taxonomy, fermentation, isolation and biological activities.

Nakae K, Yoshimoto Y, Sawa T, Homma Y, Hamada M, Takeuchi T, Imoto M.

J Antibiot (Tokyo). 2000 Oct;53(10):1130-6.

16.

Synthesis of Migrastatin Analogues as Inhibitors of Tumour Cell Migration: Exploring Structural Change in and on the Macrocyclic Ring.

Lo Re D, Zhou Y, Mucha J, Jones LF, Leahy L, Santocanale C, Krol M, Murphy PV.

Chemistry. 2015 Dec 7;21(50):18109-21. doi: 10.1002/chem.201502861. Epub 2015 Nov 4.

PMID:
26531227
17.

Synthesis of Migrastatin Analogues as Inhibitors of Tumour Cell Migration: Exploring Structural Change in and on the Macrocyclic Ring.

Lo Re D, Zhou Y, Mucha J, Jones LF, Leahy L, Santocanale C, Krol M, Murphy PV.

Chemistry. 2015 Dec 7;21(50):17993. doi: 10.1002/chem.201504167. Epub 2015 Nov 5.

PMID:
26537992
18.

Synthesis and Biological Evaluation of Lactimidomycin and Its Analogues.

Larsen BJ, Sun Z, Lachacz E, Khomutnyk Y, Soellner MB, Nagorny P.

Chemistry. 2015 Dec 21;21(52):19159-67. doi: 10.1002/chem.201503527. Epub 2015 Nov 18.

PMID:
26577990
19.

Synthesis and biological evaluation of 10,11-dihydrodictyostatin, a potent analogue of the marine anticancer agent dictyostatin.

Paterson I, Gardner NM, Poullennec KG, Wright AE.

J Nat Prod. 2008 Mar;71(3):364-9. Epub 2007 Dec 15.

PMID:
18081257
20.

Complex synthesis yields breast-cancer therapy.

Ledford H.

Nature. 2010 Dec 2;468(7324):608-9. doi: 10.1038/468608a. No abstract available.

PMID:
21124423

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