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Items: 1 to 20 of 82

1.

NF2-deficient cells depend on the Rac1-canonical Wnt signaling pathway to promote the loss of contact inhibition of proliferation.

Bosco EE, Nakai Y, Hennigan RF, Ratner N, Zheng Y.

Oncogene. 2010 Apr 29;29(17):2540-9. doi: 10.1038/onc.2010.20. Epub 2010 Feb 15.

2.
3.

Rac1 is required for Prkar1a-mediated Nf2 suppression in Schwann cell tumors.

Manchanda PK, Jones GN, Lee AA, Pringle DR, Zhang M, Yu L, La Perle KM, Kirschner LS.

Oncogene. 2013 Jul 25;32(30):3491-9. doi: 10.1038/onc.2012.374. Epub 2012 Oct 8.

4.

NF2/merlin is a novel negative regulator of mTOR complex 1, and activation of mTORC1 is associated with meningioma and schwannoma growth.

James MF, Han S, Polizzano C, Plotkin SR, Manning BD, Stemmer-Rachamimov AO, Gusella JF, Ramesh V.

Mol Cell Biol. 2009 Aug;29(15):4250-61. doi: 10.1128/MCB.01581-08. Epub 2009 May 18.

5.

Contact-dependent inhibition of EGFR signaling by Nf2/Merlin.

Curto M, Cole BK, Lallemand D, Liu CH, McClatchey AI.

J Cell Biol. 2007 Jun 4;177(5):893-903.

6.

The Nf2 tumor suppressor, merlin, functions in Rac-dependent signaling.

Shaw RJ, Paez JG, Curto M, Yaktine A, Pruitt WM, Saotome I, O'Bryan JP, Gupta V, Ratner N, Der CJ, Jacks T, McClatchey AI.

Dev Cell. 2001 Jul;1(1):63-72.

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8.

A tight junction-associated Merlin-angiomotin complex mediates Merlin's regulation of mitogenic signaling and tumor suppressive functions.

Yi C, Troutman S, Fera D, Stemmer-Rachamimov A, Avila JL, Christian N, Persson NL, Shimono A, Speicher DW, Marmorstein R, Holmgren L, Kissil JL.

Cancer Cell. 2011 Apr 12;19(4):527-40. doi: 10.1016/j.ccr.2011.02.017.

9.

Merlin/NF2 functions upstream of the nuclear E3 ubiquitin ligase CRL4DCAF1 to suppress oncogenic gene expression.

Cooper J, Li W, You L, Schiavon G, Pepe-Caprio A, Zhou L, Ishii R, Giovannini M, Hanemann CO, Long SB, Erdjument-Bromage H, Zhou P, Tempst P, Giancotti FG.

Sci Signal. 2011 Aug 23;4(188):pt6. doi: 10.1126/scisignal.2002314.

PMID:
21878678
10.

Merlin is a potent inhibitor of glioma growth.

Lau YK, Murray LB, Houshmandi SS, Xu Y, Gutmann DH, Yu Q.

Cancer Res. 2008 Jul 15;68(14):5733-42. doi: 10.1158/0008-5472.CAN-08-0190.

11.

The NF2 tumor suppressor gene product, merlin, inhibits cell proliferation and cell cycle progression by repressing cyclin D1 expression.

Xiao GH, Gallagher R, Shetler J, Skele K, Altomare DA, Pestell RG, Jhanwar S, Testa JR.

Mol Cell Biol. 2005 Mar;25(6):2384-94.

12.

Rac1-Mediated DNA Damage and Inflammation Promote Nf2 Tumorigenesis but Also Limit Cell-Cycle Progression.

Shi Y, Bollam SR, White SM, Laughlin SZ, Graham GT, Wadhwa M, Chen H, Nguyen C, Vitte J, Giovannini M, Toretsky J, Yi C.

Dev Cell. 2016 Nov 21;39(4):452-465. doi: 10.1016/j.devcel.2016.09.027. Epub 2016 Nov 3.

13.

NF2/Merlin is required for the axial pattern formation in the Xenopus laevis embryo.

Zhu X, Min Z, Tan R, Tao Q.

Mech Dev. 2015 Nov;138 Pt 3:305-12. doi: 10.1016/j.mod.2015.08.008. Epub 2015 Sep 3.

14.

NF2 deficiency promotes tumorigenesis and metastasis by destabilizing adherens junctions.

Lallemand D, Curto M, Saotome I, Giovannini M, McClatchey AI.

Genes Dev. 2003 May 1;17(9):1090-100. Epub 2003 Apr 14.

15.

Rac1 controls Schwann cell myelination through cAMP and NF2/merlin.

Guo L, Moon C, Niehaus K, Zheng Y, Ratner N.

J Neurosci. 2012 Nov 28;32(48):17251-61. doi: 10.1523/JNEUROSCI.2461-12.2012.

16.

NF2/Merlin mediates contact-dependent inhibition of EGFR mobility and internalization via cortical actomyosin.

Chiasson-MacKenzie C, Morris ZS, Baca Q, Morris B, Coker JK, Mirchev R, Jensen AE, Carey T, Stott SL, Golan DE, McClatchey AI.

J Cell Biol. 2015 Oct 26;211(2):391-405. doi: 10.1083/jcb.201503081. Epub 2015 Oct 19.

17.

The neurofibromatosis 2 protein, merlin, regulates glial cell growth in an ErbB2- and Src-dependent manner.

Houshmandi SS, Emnett RJ, Giovannini M, Gutmann DH.

Mol Cell Biol. 2009 Mar;29(6):1472-86. doi: 10.1128/MCB.01392-08. Epub 2008 Dec 22.

18.

The neurofibromatosis 2 tumor suppressor gene product, merlin, regulates human meningioma cell growth by signaling through YAP.

Striedinger K, VandenBerg SR, Baia GS, McDermott MW, Gutmann DH, Lal A.

Neoplasia. 2008 Nov;10(11):1204-12.

19.

A clue to the therapy of neurofibromatosis type 2: NF2/merlin is a PAK1 inhibitor.

Hirokawa Y, Tikoo A, Huynh J, Utermark T, Hanemann CO, Giovannini M, Xiao GH, Testa JR, Wood J, Maruta H.

Cancer J. 2004 Jan-Feb;10(1):20-6.

PMID:
15000491
20.

Merlin/NF2-Lin28B-let-7 Is a Tumor-Suppressive Pathway that Is Cell-Density Dependent and Hippo Independent.

Hikasa H, Sekido Y, Suzuki A.

Cell Rep. 2016 Mar 29;14(12):2950-61. doi: 10.1016/j.celrep.2016.02.075. Epub 2016 Mar 17.

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