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In vivo role of leukocyte ADAM17 in the inflammatory and host responses during E. coli-mediated peritonitis.

Long C, Wang Y, Herrera AH, Horiuchi K, Walcheck B.

J Leukoc Biol. 2010 Jun;87(6):1097-101. doi: 10.1189/jlb.1109763. Epub 2010 Feb 12.


IL-10-deficient mice demonstrate multiple organ failure and increased mortality during Escherichia coli peritonitis despite an accelerated bacterial clearance.

Sewnath ME, Olszyna DP, Birjmohun R, ten Kate FJ, Gouma DJ, van Der Poll T.

J Immunol. 2001 May 15;166(10):6323-31.


ADAM17 activation in circulating neutrophils following bacterial challenge impairs their recruitment.

Long C, Hosseinkhani MR, Wang Y, Sriramarao P, Walcheck B.

J Leukoc Biol. 2012 Sep;92(3):667-72. doi: 10.1189/jlb.0312112. Epub 2012 May 23.


ADAM17 activity and other mechanisms of soluble L-selectin production during death receptor-induced leukocyte apoptosis.

Wang Y, Zhang AC, Ni Z, Herrera A, Walcheck B.

J Immunol. 2010 Apr 15;184(8):4447-54. doi: 10.4049/jimmunol.0902925. Epub 2010 Mar 10.


Adam17-dependent shedding limits early neutrophil influx but does not alter early monocyte recruitment to inflammatory sites.

Tang J, Zarbock A, Gomez I, Wilson CL, Lefort CT, Stadtmann A, Bell B, Huang LC, Ley K, Raines EW.

Blood. 2011 Jul 21;118(3):786-94. doi: 10.1182/blood-2010-11-321406. Epub 2011 May 31.


ADAM17 deficiency by mature neutrophils has differential effects on L-selectin shedding.

Li Y, Brazzell J, Herrera A, Walcheck B.

Blood. 2006 Oct 1;108(7):2275-9. Epub 2006 May 30.


Leukocyte ADAM17 regulates acute pulmonary inflammation.

Arndt PG, Strahan B, Wang Y, Long C, Horiuchi K, Walcheck B.

PLoS One. 2011;6(5):e19938. doi: 10.1371/journal.pone.0019938. Epub 2011 May 16.


Lipopolysaccharide binding protein is an essential component of the innate immune response to Escherichia coli peritonitis in mice.

Knapp S, de Vos AF, Florquin S, Golenbock DT, van der Poll T.

Infect Immun. 2003 Dec;71(12):6747-53.


Regulation of peritoneal and systemic neutrophil-derived tumor necrosis factor-alpha release in patients with severe peritonitis: role of tumor necrosis factor-alpha converting enzyme cleavage.

Kermarrec N, Selloum S, Plantefeve G, Chosidow D, Paoletti X, Lopez A, Mantz J, Desmonts JM, Gougerot-Pocidalo MA, Chollet-Martin S.

Crit Care Med. 2005 Jun;33(6):1359-64.


Critical role of the disintegrin metalloprotease ADAM17 for intestinal inflammation and regeneration in mice.

Chalaris A, Adam N, Sina C, Rosenstiel P, Lehmann-Koch J, Schirmacher P, Hartmann D, Cichy J, Gavrilova O, Schreiber S, Jostock T, Matthews V, Häsler R, Becker C, Neurath MF, Reiss K, Saftig P, Scheller J, Rose-John S.

J Exp Med. 2010 Aug 2;207(8):1617-24. doi: 10.1084/jem.20092366. Epub 2010 Jul 5.


Regulation of mature ADAM17 by redox agents for L-selectin shedding.

Wang Y, Herrera AH, Li Y, Belani KK, Walcheck B.

J Immunol. 2009 Feb 15;182(4):2449-57. doi: 10.4049/jimmunol.0802770.


Targeting ADAM17 in leukocytes increases neutrophil recruitment and reduces bacterial spread during polymicrobial sepsis.

Mishra HK, Johnson TJ, Seelig DM, Walcheck B.

J Leukoc Biol. 2016 Nov;100(5):999-1004. Epub 2016 Apr 8.


Neutrophil adhesion to E-selectin under shear promotes the redistribution and co-clustering of ADAM17 and its proteolytic substrate L-selectin.

Schaff U, Mattila PE, Simon SI, Walcheck B.

J Leukoc Biol. 2008 Jan;83(1):99-105. Epub 2007 Oct 10.


Role of ADAM17 in the ectodomain shedding of TNF-alpha and its receptors by neutrophils and macrophages.

Bell JH, Herrera AH, Li Y, Walcheck B.

J Leukoc Biol. 2007 Jul;82(1):173-6. Epub 2007 May 17.


Lung endothelial ADAM17 regulates the acute inflammatory response to lipopolysaccharide.

Dreymueller D, Martin C, Kogel T, Pruessmeyer J, Hess FM, Horiuchi K, Uhlig S, Ludwig A.

EMBO Mol Med. 2012 May;4(5):412-23. doi: 10.1002/emmm.201200217. Epub 2012 Feb 24.


Immune protection against septic peritonitis in endotoxin-primed mice is related to reduced neutrophil apoptosis.

Feterowski C, Weighardt H, Emmanuilidis K, Hartung T, Holzmann B.

Eur J Immunol. 2001 Apr;31(4):1268-77.


ADAM17 but not ADAM10 mediates tumor necrosis factor-alpha and L-selectin shedding from leukocyte membranes.

Condon TP, Flournoy S, Sawyer GJ, Baker BF, Kishimoto TK, Bennett CF.

Antisense Nucleic Acid Drug Dev. 2001 Apr;11(2):107-16.


ADAM17 activity during human neutrophil activation and apoptosis.

Walcheck B, Herrera AH, St Hill C, Mattila PE, Whitney AR, Deleo FR.

Eur J Immunol. 2006 Apr;36(4):968-76.

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