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Dissection of the molecular basis for hypervirulence of an in vivo-selected phenotype of the widely disseminated M1T1 strain of group A Streptococcus bacteria.

Kansal RG, Datta V, Aziz RK, Abdeltawab NF, Rowe S, Kotb M.

J Infect Dis. 2010 Mar 15;201(6):855-65. doi: 10.1086/651019. Erratum in: J Infect Dis. 2010 Jun 1;201(11):1778-80.


Mutations in the control of virulence sensor gene from Streptococcus pyogenes after infection in mice lead to clonal bacterial variants with altered gene regulatory activity and virulence.

Mayfield JA, Liang Z, Agrahari G, Lee SW, Donahue DL, Ploplis VA, Castellino FJ.

PLoS One. 2014 Jun 26;9(6):e100698. doi: 10.1371/journal.pone.0100698. eCollection 2014.


Null Mutations of Group A Streptococcus Orphan Kinase RocA: Selection in Mouse Infection and Comparison with CovS Mutations in Alteration of In Vitro and In Vivo Protease SpeB Expression and Virulence.

Feng W, Minor D, Liu M, Li J, Ishaq SL, Yeoman C, Lei B.

Infect Immun. 2016 Dec 29;85(1). pii: e00790-16. doi: 10.1128/IAI.00790-16. Print 2017 Jan.


CovRS-Regulated Transcriptome Analysis of a Hypervirulent M23 Strain of Group A Streptococcus pyogenes Provides New Insights into Virulence Determinants.

Bao YJ, Liang Z, Mayfield JA, Lee SW, Ploplis VA, Castellino FJ.

J Bacteriol. 2015 Oct;197(19):3191-205. doi: 10.1128/JB.00511-15. Epub 2015 Jul 27.


A natural inactivating mutation in the CovS component of the CovRS regulatory operon in a pattern D Streptococcal pyogenes strain influences virulence-associated genes.

Liang Z, Zhang Y, Agrahari G, Chandrahas V, Glinton K, Donahue DL, Balsara RD, Ploplis VA, Castellino FJ.

J Biol Chem. 2013 Mar 1;288(9):6561-73. doi: 10.1074/jbc.M112.442657. Epub 2013 Jan 13.


Invasive M1T1 group A Streptococcus undergoes a phase-shift in vivo to prevent proteolytic degradation of multiple virulence factors by SpeB.

Aziz RK, Pabst MJ, Jeng A, Kansal R, Low DE, Nizet V, Kotb M.

Mol Microbiol. 2004 Jan;51(1):123-34.


Serotype M3 and M28 Group A Streptococci Have Distinct Capacities to Evade Neutrophil and TNF-α Responses and to Invade Soft Tissues.

Stetzner ZW, Li D, Feng W, Liu M, Liu G, Wiley J, Lei B.

PLoS One. 2015 Jun 5;10(6):e0129417. doi: 10.1371/journal.pone.0129417. eCollection 2015.


CovS simultaneously activates and inhibits the CovR-mediated repression of distinct subsets of group A Streptococcus virulence factor-encoding genes.

Treviño J, Perez N, Ramirez-Peña E, Liu Z, Shelburne SA 3rd, Musser JM, Sumby P.

Infect Immun. 2009 Aug;77(8):3141-9. doi: 10.1128/IAI.01560-08. Epub 2009 May 18.


Partial loss of CovS function in Streptococcus pyogenes causes severe invasive disease.

Tatsuno I, Okada R, Zhang Y, Isaka M, Hasegawa T.

BMC Res Notes. 2013 Mar 28;6:126. doi: 10.1186/1756-0500-6-126.


Description of the Pathogenic Features of Streptococcus pyogenes Isolates from Invasive and Non-Invasive Diseases in Aichi, Japan.

Matsumoto M, Yamada K, Suzuki M, Adachi H, Kobayashi S, Yamashita T, Minagawa H, Tatsuno I, Hasegawa T.

Jpn J Infect Dis. 2016 Jul 22;69(4):338-41. doi: 10.7883/yoken.JJID.2015.334. Epub 2015 Nov 13.


Streptococcal inhibitor of complement promotes innate immune resistance phenotypes of invasive M1T1 group A Streptococcus.

Pence MA, Rooijakkers SH, Cogen AL, Cole JN, Hollands A, Gallo RL, Nizet V.

J Innate Immun. 2010;2(6):587-95. doi: 10.1159/000317672. Epub 2010 Sep 1.


Genetic switch to hypervirulence reduces colonization phenotypes of the globally disseminated group A streptococcus M1T1 clone.

Hollands A, Pence MA, Timmer AM, Osvath SR, Turnbull L, Whitchurch CB, Walker MJ, Nizet V.

J Infect Dis. 2010 Jul 1;202(1):11-9. doi: 10.1086/653124.


Reciprocal, temporal expression of SpeA and SpeB by invasive M1T1 group a streptococcal isolates in vivo.

Kazmi SU, Kansal R, Aziz RK, Hooshdaran M, Norrby-Teglund A, Low DE, Halim AB, Kotb M.

Infect Immun. 2001 Aug;69(8):4988-95.


Microevolution of group A streptococci in vivo: capturing regulatory networks engaged in sociomicrobiology, niche adaptation, and hypervirulence.

Aziz RK, Kansal R, Aronow BJ, Taylor WL, Rowe SL, Kubal M, Chhatwal GS, Walker MJ, Kotb M.

PLoS One. 2010 Apr 14;5(4):e9798. doi: 10.1371/journal.pone.0009798.


Neutrophils select hypervirulent CovRS mutants of M1T1 group A Streptococcus during subcutaneous infection of mice.

Li J, Liu G, Feng W, Zhou Y, Liu M, Wiley JA, Lei B.

Infect Immun. 2014 Apr;82(4):1579-90. doi: 10.1128/IAI.01458-13. Epub 2014 Jan 22.


DNase Sda1 provides selection pressure for a switch to invasive group A streptococcal infection.

Walker MJ, Hollands A, Sanderson-Smith ML, Cole JN, Kirk JK, Henningham A, McArthur JD, Dinkla K, Aziz RK, Kansal RG, Simpson AJ, Buchanan JT, Chhatwal GS, Kotb M, Nizet V.

Nat Med. 2007 Aug;13(8):981-5. Epub 2007 Jul 15.


M protein and hyaluronic acid capsule are essential for in vivo selection of covRS mutations characteristic of invasive serotype M1T1 group A Streptococcus.

Cole JN, Pence MA, von Köckritz-Blickwede M, Hollands A, Gallo RL, Walker MJ, Nizet V.

MBio. 2010 Aug 31;1(4). pii: e00191-10. doi: 10.1128/mBio.00191-10.


[Detection of pyrogenic exotoxin SpeA, SpeB and SpeC genes in Chilean streptococci isolates and their association with clinical manifestations].

Ulloa MT, Giglio MS, Porte L, Santa Cruz A, McNab P, Fica A, Pinto ME, Kawaguchi K, Carmi A.

Rev Med Chil. 2000 Jan;128(1):27-34. Spanish.


The secreted esterase of group a streptococcus is important for invasive skin infection and dissemination in mice.

Zhu H, Liu M, Sumby P, Lei B.

Infect Immun. 2009 Dec;77(12):5225-32. doi: 10.1128/IAI.00636-09. Epub 2009 Oct 5.

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