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Items: 1 to 20 of 138

1.

Inhibition of mitochondrial respiration mediates apoptosis induced by the anti-tumoral alkaloid lamellarin D.

Ballot C, Kluza J, Lancel S, Martoriati A, Hassoun SM, Mortier L, Vienne JC, Briand G, Formstecher P, Bailly C, Nevière R, Marchetti P.

Apoptosis. 2010 Jul;15(7):769-81. doi: 10.1007/s10495-010-0471-2.

PMID:
20151196
2.

Cancer cell mitochondria are direct proapoptotic targets for the marine antitumor drug lamellarin D.

Kluza J, Gallego MA, Loyens A, Beauvillain JC, Sousa-Faro JM, Cuevas C, Marchetti P, Bailly C.

Cancer Res. 2006 Mar 15;66(6):3177-87.

3.

Lamellarin D: a novel pro-apoptotic agent from marine origin insensitive to P-glycoprotein-mediated drug efflux.

Vanhuyse M, Kluza J, Tardy C, Otero G, Cuevas C, Bailly C, Lansiaux A.

Cancer Lett. 2005 Apr 28;221(2):165-75.

PMID:
15808402
4.

Topoisomerase I-mediated DNA cleavage as a guide to the development of antitumor agents derived from the marine alkaloid lamellarin D: triester derivatives incorporating amino acid residues.

Tardy C, Facompré M, Laine W, Baldeyrou B, García-Gravalos D, Francesch A, Mateo C, Pastor A, Jiménez JA, Manzanares I, Cuevas C, Bailly C.

Bioorg Med Chem. 2004 Apr 1;12(7):1697-712.

PMID:
15028262
5.

Essential role of mitochondria in apoptosis of cancer cells induced by the marine alkaloid Lamellarin D.

Ballot C, Kluza J, Martoriati A, Nyman U, Formstecher P, Joseph B, Bailly C, Marchetti P.

Mol Cancer Ther. 2009 Dec;8(12):3307-17. doi: 10.1158/1535-7163.MCT-09-0639.

6.

Synthesis and structure-activity relationship study of potent cytotoxic analogues of the marine alkaloid Lamellarin D.

Pla D, Marchal A, Olsen CA, Francesch A, Cuevas C, Albericio F, Alvarez M.

J Med Chem. 2006 Jun 1;49(11):3257-68.

PMID:
16722644
7.

Lamellarin D: a novel potent inhibitor of topoisomerase I.

Facompré M, Tardy C, Bal-Mahieu C, Colson P, Perez C, Manzanares I, Cuevas C, Bailly C.

Cancer Res. 2003 Nov 1;63(21):7392-9.

8.

Overcoming chemoresistance of non-small cell lung carcinoma through restoration of an AIF-dependent apoptotic pathway.

Gallego MA, Ballot C, Kluza J, Hajji N, Martoriati A, Castéra L, Cuevas C, Formstecher P, Joseph B, Kroemer G, Bailly C, Marchetti P.

Oncogene. 2008 Mar 27;27(14):1981-92. Epub 2007 Oct 1.

PMID:
17906690
9.

Poisoning of mitochondrial topoisomerase I by lamellarin D.

Khiati S, Seol Y, Agama K, Dalla Rosa I, Agrawal S, Fesen K, Zhang H, Neuman KC, Pommier Y.

Mol Pharmacol. 2014 Aug;86(2):193-9. doi: 10.1124/mol.114.092833. Epub 2014 Jun 2.

10.

Another facet to the anticancer response to lamellarin D: induction of cellular senescence through inhibition of topoisomerase I and intracellular Ros production.

Ballot C, Martoriati A, Jendoubi M, Buche S, Formstecher P, Mortier L, Kluza J, Marchetti P.

Mar Drugs. 2014 Jan 27;12(2):779-98. doi: 10.3390/md12020779.

11.

Induction of mitochondrial permeability transition and cytochrome C release in the absence of caspase activation is insufficient for effective apoptosis in human leukemia cells.

Hirpara JL, Seyed MA, Loh KW, Dong H, Kini RM, Pervaiz S.

Blood. 2000 Mar 1;95(5):1773-80. Erratum in: Blood. 2014 Jan 9;123(2):300.

12.

Dimethylaminopyridine derivatives of lupane triterpenoids cause mitochondrial disruption and induce the permeability transition.

Bernardo TC, Cunha-Oliveira T, Serafim TL, Holy J, Krasutsky D, Kolomitsyna O, Krasutsky P, Moreno AM, Oliveira PJ.

Bioorg Med Chem. 2013 Dec 1;21(23):7239-49. doi: 10.1016/j.bmc.2013.09.066. Epub 2013 Oct 8.

PMID:
24156937
13.

Lamellarin D bioconjugates I: Synthesis and cellular internalization of PEG-derivatives.

Pla D, Francesch A, Calvo P, Cuevas C, Aligué R, Albericio F, Alvarez M.

Bioconjug Chem. 2009 Jun;20(6):1100-11. doi: 10.1021/bc800503k.

PMID:
19472995
14.

Nitric-oxide-induced necrosis and apoptosis in PC12 cells mediated by mitochondria.

Bal-Price A, Brown GC.

J Neurochem. 2000 Oct;75(4):1455-64.

15.

Evaluation of putative inhibitors of mitochondrial permeability transition for brain disorders--specificity vs. toxicity.

Morota S, Månsson R, Hansson MJ, Kasuya K, Shimazu M, Hasegawa E, Yanagi S, Omi A, Uchino H, Elmér E.

Exp Neurol. 2009 Aug;218(2):353-62. doi: 10.1016/j.expneurol.2009.03.036. Epub 2009 Apr 5.

PMID:
19348797
16.

Tributyltin causes cytochrome C release from isolated mitochondria by two discrete mechanisms.

Gogvadze V, Stridh H, Orrenius S, Cotgreave I.

Biochem Biophys Res Commun. 2002 Apr 12;292(4):904-8.

PMID:
11944900
17.

Mitochondrial toxicity of the phyotochemicals daphnetoxin and daphnoretin--relevance for possible anti-cancer application.

Diogo CV, Félix L, Vilela S, Burgeiro A, Barbosa IA, Carvalho MJ, Oliveira PJ, Peixoto FP.

Toxicol In Vitro. 2009 Aug;23(5):772-9. doi: 10.1016/j.tiv.2009.04.002. Epub 2009 Apr 9.

PMID:
19362137
18.
19.

The novel retinoid 6-[3-(1-adamantyl)-4-hydroxyphenyl]-2-naphtalene carboxylic acid can trigger apoptosis through a mitochondrial pathway independent of the nucleus.

Marchetti P, Zamzami N, Joseph B, Schraen-Maschke S, Méreau-Richard C, Costantini P, Métivier D, Susin SA, Kroemer G, Formstecher P.

Cancer Res. 1999 Dec 15;59(24):6257-66.

20.

Anticancer properties of lamellarins.

Bailly C.

Mar Drugs. 2015 Feb 19;13(3):1105-23. doi: 10.3390/md13031105. Review.

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