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Items: 1 to 20 of 118

1.

NOTCH signaling is required for formation and self-renewal of tumor-initiating cells and for repression of secretory cell differentiation in colon cancer.

Sikandar SS, Pate KT, Anderson S, Dizon D, Edwards RA, Waterman ML, Lipkin SM.

Cancer Res. 2010 Feb 15;70(4):1469-78. doi: 10.1158/0008-5472.CAN-09-2557. Epub 2010 Feb 9.

2.

NOTCH Signaling Regulates Asymmetric Cell Fate of Fast- and Slow-Cycling Colon Cancer-Initiating Cells.

Srinivasan T, Walters J, Bu P, Than EB, Tung KL, Chen KY, Panarelli N, Milsom J, Augenlicht L, Lipkin SM, Shen X.

Cancer Res. 2016 Jun 1;76(11):3411-21. doi: 10.1158/0008-5472.CAN-15-3198. Epub 2016 Apr 11.

4.

Prostaglandin E2 Promotes Colorectal Cancer Stem Cell Expansion and Metastasis in Mice.

Wang D, Fu L, Sun H, Guo L, DuBois RN.

Gastroenterology. 2015 Dec;149(7):1884-1895.e4. doi: 10.1053/j.gastro.2015.07.064. Epub 2015 Aug 7.

5.

HES1-mediated inhibition of Notch1 signaling by a Gemini vitamin D analog leads to decreased CD44(+)/CD24(-/low) tumor-initiating subpopulation in basal-like breast cancer.

So JY, Wahler J, Das Gupta S, Salerno DM, Maehr H, Uskokovic M, Suh N.

J Steroid Biochem Mol Biol. 2015 Apr;148:111-21. doi: 10.1016/j.jsbmb.2014.12.013. Epub 2014 Dec 23.

6.

STAT3 is necessary for proliferation and survival in colon cancer-initiating cells.

Lin L, Liu A, Peng Z, Lin HJ, Li PK, Li C, Lin J.

Cancer Res. 2011 Dec 1;71(23):7226-37. doi: 10.1158/0008-5472.CAN-10-4660. Epub 2011 Sep 7.

7.

MET signaling in colon cancer stem-like cells blunts the therapeutic response to EGFR inhibitors.

Luraghi P, Reato G, Cipriano E, Sassi F, Orzan F, Bigatto V, De Bacco F, Menietti E, Han M, Rideout WM 3rd, Perera T, Bertotti A, Trusolino L, Comoglio PM, Boccaccio C.

Cancer Res. 2014 Mar 15;74(6):1857-69. doi: 10.1158/0008-5472.CAN-13-2340-T. Epub 2014 Jan 21.

8.

Atonal homolog 1 is required for growth and differentiation effects of notch/gamma-secretase inhibitors on normal and cancerous intestinal epithelial cells.

Kazanjian A, Noah T, Brown D, Burkart J, Shroyer NF.

Gastroenterology. 2010 Sep;139(3):918-28, 928.e1-6. doi: 10.1053/j.gastro.2010.05.081. Epub 2010 Jun 2.

9.

KIT Signaling Promotes Growth of Colon Xenograft Tumors in Mice and Is Up-Regulated in a Subset of Human Colon Cancers.

Chen EC, Karl TA, Kalisky T, Gupta SK, O'Brien CA, Longacre TA, van de Rijn M, Quake SR, Clarke MF, Rothenberg ME.

Gastroenterology. 2015 Sep;149(3):705-17.e2. doi: 10.1053/j.gastro.2015.05.042. Epub 2015 May 28.

10.

Inhibition of ataxia telangiectasia- and Rad3-related function abrogates the in vitro and in vivo tumorigenicity of human colon cancer cells through depletion of the CD133(+) tumor-initiating cell fraction.

Gallmeier E, Hermann PC, Mueller MT, Machado JG, Ziesch A, De Toni EN, Palagyi A, Eisen C, Ellwart JW, Rivera J, Rubio-Viqueira B, Hidalgo M, Bunz F, Göke B, Heeschen C.

Stem Cells. 2011 Mar;29(3):418-29. doi: 10.1002/stem.595.

11.

Portulaca oleracea extract can inhibit nodule formation of colon cancer stem cells by regulating gene expression of the Notch signal transduction pathway.

Jin H, Chen L, Wang S, Chao D.

Tumour Biol. 2017 Jul;39(7):1010428317708699. doi: 10.1177/1010428317708699.

PMID:
28714363
12.

Dclk1, a tumor stem cell marker, regulates pro-survival signaling and self-renewal of intestinal tumor cells.

Chandrakesan P, Yao J, Qu D, May R, Weygant N, Ge Y, Ali N, Sureban SM, Gude M, Vega K, Bannerman-Menson E, Xia L, Bronze M, An G, Houchen CW.

Mol Cancer. 2017 Feb 1;16(1):30. doi: 10.1186/s12943-017-0594-y.

13.

FOXM1-Induced PRX3 Regulates Stemness and Survival of Colon Cancer Cells via Maintenance of Mitochondrial Function.

Song IS, Jeong YJ, Jeong SH, Heo HJ, Kim HK, Bae KB, Park YH, Kim SU, Kim JM, Kim N, Ko KS, Rhee BD, Han J.

Gastroenterology. 2015 Oct;149(4):1006-16.e9. doi: 10.1053/j.gastro.2015.06.007. Epub 2015 Jun 17.

PMID:
26091938
14.

Loss of Mel-18 enhances breast cancer stem cell activity and tumorigenicity through activating Notch signaling mediated by the Wnt/TCF pathway.

Won HY, Lee JY, Shin DH, Park JH, Nam JS, Kim HC, Kong G.

FASEB J. 2012 Dec;26(12):5002-13. doi: 10.1096/fj.12-209247. Epub 2012 Sep 5.

PMID:
22954590
15.

Suppression of renal cell carcinoma growth by inhibition of Notch signaling in vitro and in vivo.

Sjölund J, Johansson M, Manna S, Norin C, Pietras A, Beckman S, Nilsson E, Ljungberg B, Axelson H.

J Clin Invest. 2008 Jan;118(1):217-28.

16.

ID1 and ID3 regulate the self-renewal capacity of human colon cancer-initiating cells through p21.

O'Brien CA, Kreso A, Ryan P, Hermans KG, Gibson L, Wang Y, Tsatsanis A, Gallinger S, Dick JE.

Cancer Cell. 2012 Jun 12;21(6):777-92. doi: 10.1016/j.ccr.2012.04.036.

17.

Notch inhibits expression of the Krüppel-like factor 4 tumor suppressor in the intestinal epithelium.

Ghaleb AM, Aggarwal G, Bialkowska AB, Nandan MO, Yang VW.

Mol Cancer Res. 2008 Dec;6(12):1920-7. doi: 10.1158/1541-7786.MCR-08-0224.

18.

DNA methyltransferase 1 is essential for initiation of the colon cancers.

Morita R, Hirohashi Y, Suzuki H, Takahashi A, Tamura Y, Kanaseki T, Asanuma H, Inoda S, Kondo T, Hashino S, Hasegawa T, Tokino T, Toyota M, Asaka M, Torigoe T, Sato N.

Exp Mol Pathol. 2013 Apr;94(2):322-9. doi: 10.1016/j.yexmp.2012.10.004. Epub 2012 Oct 9.

PMID:
23064049
19.

Highly enriched CD133(+)CD44(+) stem-like cells with CD133(+)CD44(high) metastatic subset in HCT116 colon cancer cells.

Chen KL, Pan F, Jiang H, Chen JF, Pei L, Xie FW, Liang HJ.

Clin Exp Metastasis. 2011 Dec;28(8):751-63. doi: 10.1007/s10585-011-9407-7. Epub 2011 Jul 13.

PMID:
21750907
20.

Pien Tze Huang inhibits the proliferation, and induces the apoptosis and differentiation of colorectal cancer stem cells via suppression of the Notch1 pathway.

Qi F, Wei L, Shen A, Chen Y, Lin J, Chu J, Cai Q, Pan J, Peng J.

Oncol Rep. 2016 Jan;35(1):511-7. doi: 10.3892/or.2015.4378. Epub 2015 Nov 2.

PMID:
26530025

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