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Tumor detection by imaging proteolytic activity.

Darragh MR, Schneider EL, Lou J, Phojanakong PJ, Farady CJ, Marks JD, Hann BC, Craik CS.

Cancer Res. 2010 Feb 15;70(4):1505-12. doi: 10.1158/0008-5472.CAN-09-1640. Epub 2010 Feb 9.


Imaging a functional tumorigenic biomarker in the transformed epithelium.

LeBeau AM, Lee M, Murphy ST, Hann BC, Warren RS, Delos Santos R, Kurhanewicz J, Hanash SM, VanBrocklin HF, Craik CS.

Proc Natl Acad Sci U S A. 2013 Jan 2;110(1):93-8. doi: 10.1073/pnas.1218694110. Epub 2012 Dec 17.


Membrane-type serine protease-1/matriptase induces interleukin-6 and -8 in endothelial cells by activation of protease-activated receptor-2: potential implications in atherosclerosis.

Seitz I, Hess S, Schulz H, Eckl R, Busch G, Montens HP, Brandl R, Seidl S, Schömig A, Ott I.

Arterioscler Thromb Vasc Biol. 2007 Apr;27(4):769-75. Epub 2007 Jan 25.


Coordinate expression and functional profiling identify an extracellular proteolytic signaling pathway.

Bhatt AS, Welm A, Farady CJ, Vásquez M, Wilson K, Craik CS.

Proc Natl Acad Sci U S A. 2007 Apr 3;104(14):5771-6. Epub 2007 Mar 27.


Potent and selective inhibition of membrane-type serine protease 1 by human single-chain antibodies.

Sun J, Pons J, Craik CS.

Biochemistry. 2003 Feb 4;42(4):892-900.


Time-domain in vivo near infrared fluorescence imaging for evaluation of matriptase as a potential target for the development of novel, inhibitor-based tumor therapies.

Napp J, Dullin C, Müller F, Uhland K, Petri JB, van de Locht A, Steinmetzer T, Alves F.

Int J Cancer. 2010 Oct 15;127(8):1958-74. doi: 10.1002/ijc.25405.


Regulation of the activity of matriptase on epithelial cell surfaces by a blood-derived factor.

Benaud C, Dickson RB, Lin CY.

Eur J Biochem. 2001 Mar;268(5):1439-47.


Inhibition of membrane-type serine protease 1/matriptase by natural and synthetic protease inhibitors.

Yamasaki Y, Satomi S, Murai N, Tsuzuki S, Fushiki T.

J Nutr Sci Vitaminol (Tokyo). 2003 Feb;49(1):27-32.


HAI-1 regulates activation and expression of matriptase, a membrane-bound serine protease.

Oberst MD, Chen LY, Kiyomiya K, Williams CA, Lee MS, Johnson MD, Dickson RB, Lin CY.

Am J Physiol Cell Physiol. 2005 Aug;289(2):C462-70. Epub 2005 Mar 30.


Quantitation of membrane type serine protease 1 (MT-SP1) in transformed and normal cells.

Bhatt AS, Takeuchi T, Ylstra B, Ginzinger D, Albertson D, Shuman MA, Craik CS.

Biol Chem. 2003 Feb;384(2):257-66.


The novel serine protease tumor-associated differentially expressed gene-15 (matriptase/MT-SP1) is highly overexpressed in cervical carcinoma.

Santin AD, Cane' S, Bellone S, Bignotti E, Palmieri M, De Las Casas LE, Anfossi S, Roman JJ, O'Brien T, Pecorelli S.

Cancer. 2003 Nov 1;98(9):1898-904.


Catalytic domain structures of MT-SP1/matriptase, a matrix-degrading transmembrane serine proteinase.

Friedrich R, Fuentes-Prior P, Ong E, Coombs G, Hunter M, Oehler R, Pierson D, Gonzalez R, Huber R, Bode W, Madison EL.

J Biol Chem. 2002 Jan 18;277(3):2160-8. Epub 2001 Nov 5.


Matriptase and HAI-1 are expressed by normal and malignant epithelial cells in vitro and in vivo.

Oberst M, Anders J, Xie B, Singh B, Ossandon M, Johnson M, Dickson RB, Lin CY.

Am J Pathol. 2001 Apr;158(4):1301-11.


Cleavage of hepatocyte growth factor activator inhibitor-1 by membrane-type MMP-1 activates matriptase.

Domoto T, Takino T, Guo L, Sato H.

Cancer Sci. 2012 Mar;103(3):448-54. doi: 10.1111/j.1349-7006.2011.02162.x. Epub 2011 Dec 28.


Matriptase/MT-SP1 is required for postnatal survival, epidermal barrier function, hair follicle development, and thymic homeostasis.

List K, Haudenschild CC, Szabo R, Chen W, Wahl SM, Swaim W, Engelholm LH, Behrendt N, Bugge TH.

Oncogene. 2002 May 23;21(23):3765-79.


MT-SP1 proteolysis and regulation of cell-microenvironment interactions.

Darragh MR, Bhatt AS, Craik CS.

Front Biosci. 2008 Jan 1;13:528-39.


Evidence for the occurrence of membrane-type serine protease 1/matriptase on the basolateral sides of enterocytes.

Tsuzuki S, Murai N, Miyake Y, Inouye K, Hirayasu H, Iwanaga T, Fushiki T.

Biochem J. 2005 Jun 1;388(Pt 2):679-87.


Matriptase: potent proteolysis on the cell surface.

List K, Bugge TH, Szabo R.

Mol Med. 2006 Jan-Mar;12(1-3):1-7. Review.

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