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Items: 1 to 20 of 79

1.

Double-stranded RNA-dependent protein kinase links pathogen sensing with stress and metabolic homeostasis.

Nakamura T, Furuhashi M, Li P, Cao H, Tuncman G, Sonenberg N, Gorgun CZ, Hotamisligil GS.

Cell. 2010 Feb 5;140(3):338-48. doi: 10.1016/j.cell.2010.01.001.

2.

Double-stranded RNA-activated protein kinase is a key modulator of insulin sensitivity in physiological conditions and in obesity in mice.

Carvalho-Filho MA, Carvalho BM, Oliveira AG, Guadagnini D, Ueno M, Dias MM, Tsukumo DM, Hirabara SM, Reis LF, Curi R, Carvalheira JB, Saad MJ.

Endocrinology. 2012 Nov;153(11):5261-74. doi: 10.1210/en.2012-1400. Epub 2012 Sep 4.

PMID:
22948222
3.

Modulation of double-stranded RNA-activated protein kinase in insulin sensitive tissues of obese humans.

Carvalho BM, Oliveira AG, Ueno M, Araújo TG, Guadagnini D, Carvalho-Filho MA, Geloneze B, Lima MM, Pareja JC, Carvalheira JB, Saad MJ.

Obesity (Silver Spring). 2013 Dec;21(12):2452-7. doi: 10.1002/oby.20410. Epub 2013 Jun 11.

4.

Sustained Action of Ceramide on the Insulin Signaling Pathway in Muscle Cells: IMPLICATION OF THE DOUBLE-STRANDED RNA-ACTIVATED PROTEIN KINASE.

Hage Hassan R, Pacheco de Sousa AC, Mahfouz R, Hainault I, Blachnio-Zabielska A, Bourron O, Koskas F, Górski J, Ferré P, Foufelle F, Hajduch E.

J Biol Chem. 2016 Feb 5;291(6):3019-29. doi: 10.1074/jbc.M115.686949. Epub 2015 Dec 23.

5.

A critical role for PKR complexes with TRBP in Immunometabolic regulation and eIF2α phosphorylation in obesity.

Nakamura T, Kunz RC, Zhang C, Kimura T, Yuan CL, Baccaro B, Namiki Y, Gygi SP, Hotamisligil GS.

Cell Rep. 2015 Apr 14;11(2):295-307. doi: 10.1016/j.celrep.2015.03.021. Epub 2015 Apr 2.

6.

Metaflammasome components in the human brain: a role in dementia with Alzheimer's pathology?

Taga M, Minett T, Classey J, Matthews FE, Brayne C, Ince PG, Nicoll JA, Hugon J, Boche D; MRC CFAS..

Brain Pathol. 2017 May;27(3):266-275. doi: 10.1111/bpa.12388. Epub 2016 Jun 8.

7.

Small-molecule inhibitors of PKR improve glucose homeostasis in obese diabetic mice.

Nakamura T, Arduini A, Baccaro B, Furuhashi M, Hotamisligil GS.

Diabetes. 2014 Feb;63(2):526-34. doi: 10.2337/db13-1019. Epub 2013 Oct 22.

8.
9.

The double-stranded RNA-dependent protein kinase differentially regulates insulin receptor substrates 1 and 2 in HepG2 cells.

Yang X, Nath A, Opperman MJ, Chan C.

Mol Biol Cell. 2010 Oct 1;21(19):3449-58. doi: 10.1091/mbc.E10-06-0481. Epub 2010 Aug 4.

10.

Stress granules regulate double-stranded RNA-dependent protein kinase activation through a complex containing G3BP1 and Caprin1.

Reineke LC, Kedersha N, Langereis MA, van Kuppeveld FJ, Lloyd RE.

MBio. 2015 Mar 17;6(2):e02486. doi: 10.1128/mBio.02486-14.

11.
12.

PKR regulates TLR2/TLR4-dependent signaling in murine alveolar macrophages.

Cabanski M, Steinmüller M, Marsh LM, Surdziel E, Seeger W, Lohmeyer J.

Am J Respir Cell Mol Biol. 2008 Jan;38(1):26-31. Epub 2007 Aug 9.

PMID:
17690330
13.
14.

Genetic deletion of PKR abrogates TNF-induced activation of IkappaBalpha kinase, JNK, Akt and cell proliferation but potentiates p44/p42 MAPK and p38 MAPK activation.

Takada Y, Ichikawa H, Pataer A, Swisher S, Aggarwal BB.

Oncogene. 2007 Feb 22;26(8):1201-12. Epub 2006 Aug 21.

PMID:
16924232
15.

Protein kinase R-dependent regulation of interleukin-10 in response to double-stranded RNA.

Chakrabarti A, Sadler AJ, Kar N, Young HA, Silverman RH, Williams BR.

J Biol Chem. 2008 Sep 12;283(37):25132-9. doi: 10.1074/jbc.M804770200. Epub 2008 Jul 14.

16.

Involvement of double-stranded RNA-dependent protein kinase in ER stress-induced retinal neuron damage.

Shimazawa M, Ito Y, Inokuchi Y, Hara H.

Invest Ophthalmol Vis Sci. 2007 Aug;48(8):3729-36.

PMID:
17652745
17.

Protein kinase PKR-dependent activation of mitogen-activated protein kinases occurs through mitochondrial adapter IPS-1 and is antagonized by vaccinia virus E3L.

Zhang P, Langland JO, Jacobs BL, Samuel CE.

J Virol. 2009 Jun;83(11):5718-25. doi: 10.1128/JVI.00224-09. Epub 2009 Mar 25.

19.

Inhibition of PKR protects against tunicamycin-induced apoptosis in neuroblastoma cells.

Vaughn LS, Snee B, Patel RC.

Gene. 2014 Feb 15;536(1):90-6. doi: 10.1016/j.gene.2013.11.074. Epub 2013 Dec 14.

PMID:
24334130
20.

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