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Items: 1 to 20 of 97

1.

ACAT1 gene ablation increases 24(S)-hydroxycholesterol content in the brain and ameliorates amyloid pathology in mice with AD.

Bryleva EY, Rogers MA, Chang CC, Buen F, Harris BT, Rousselet E, Seidah NG, Oddo S, LaFerla FM, Spencer TA, Hickey WF, Chang TY.

Proc Natl Acad Sci U S A. 2010 Feb 16;107(7):3081-6. doi: 10.1073/pnas.0913828107. Epub 2010 Jan 26.

2.

Acyl-coenzyme A:cholesterol acyltransferase 1 blockage enhances autophagy in the neurons of triple transgenic Alzheimer's disease mouse and reduces human P301L-tau content at the presymptomatic stage.

Shibuya Y, Niu Z, Bryleva EY, Harris BT, Murphy SR, Kheirollah A, Bowen ZD, Chang CC, Chang TY.

Neurobiol Aging. 2015 Jul;36(7):2248-59. doi: 10.1016/j.neurobiolaging.2015.04.002. Epub 2015 Apr 7.

3.

Acat1 knockdown gene therapy decreases amyloid-β in a mouse model of Alzheimer's disease.

Murphy SR, Chang CC, Dogbevia G, Bryleva EY, Bowen Z, Hasan MT, Chang TY.

Mol Ther. 2013 Aug;21(8):1497-506. doi: 10.1038/mt.2013.118. Epub 2013 Jun 18.

4.

Neuronal cholesterol esterification by ACAT1 in Alzheimer's disease.

Chang TY, Chang CC, Bryleva E, Rogers MA, Murphy SR.

IUBMB Life. 2010 Apr;62(4):261-7. doi: 10.1002/iub.305. Review.

5.

ACAT1/SOAT1 as a therapeutic target for Alzheimer's disease.

Shibuya Y, Chang CC, Chang TY.

Future Med Chem. 2015;7(18):2451-67. doi: 10.4155/fmc.15.161. Epub 2015 Dec 15. Review.

6.

ACAT inhibition and amyloid beta reduction.

Bhattacharyya R, Kovacs DM.

Biochim Biophys Acta. 2010 Aug;1801(8):960-5. doi: 10.1016/j.bbalip.2010.04.003. Epub 2010 Apr 14. Review.

7.

Role of acyl-coenzyme a: cholesterol acyltransferase activity in the processing of the amyloid precursor protein.

Puglielli L, Ellis BC, Ingano LA, Kovacs DM.

J Mol Neurosci. 2004;24(1):93-6. Review.

PMID:
15314256
8.

Cellular pregnenolone esterification by acyl-CoA:cholesterol acyltransferase.

Rogers MA, Liu J, Kushnir MM, Bryleva E, Rockwood AL, Meikle AW, Shapiro D, Vaisman BL, Remaley AT, Chang CC, Chang TY.

J Biol Chem. 2012 May 18;287(21):17483-92. doi: 10.1074/jbc.M111.331306. Epub 2012 Apr 2.

9.

Acat1 gene ablation in mice increases hematopoietic progenitor cell proliferation in bone marrow and causes leukocytosis.

Huang LH, Gui J, Artinger E, Craig R, Berwin BL, Ernst PA, Chang CC, Chang TY.

Arterioscler Thromb Vasc Biol. 2013 Sep;33(9):2081-7. doi: 10.1161/ATVBAHA.112.301080. Epub 2013 Jul 11.

10.

Cholesterol 24-hydroxylase defect is implicated in memory impairments associated with Alzheimer-like Tau pathology.

Burlot MA, Braudeau J, Michaelsen-Preusse K, Potier B, Ayciriex S, Varin J, Gautier B, Djelti F, Audrain M, Dauphinot L, Fernandez-Gomez FJ, Caillierez R, Laprévote O, Bièche I, Auzeil N, Potier MC, Dutar P, Korte M, Buée L, Blum D, Cartier N.

Hum Mol Genet. 2015 Nov 1;24(21):5965-76. doi: 10.1093/hmg/ddv268. Epub 2015 Sep 10.

PMID:
26358780
11.

Neurodegenerative Alzheimer-like pathology in PDAPP 717V-->F transgenic mice.

Chen KS, Masliah E, Grajeda H, Guido T, Huang J, Khan K, Motter R, Soriano F, Games D.

Prog Brain Res. 1998;117:327-34. Review.

PMID:
9932418
12.

Biochemical and behavioral characterization of the double transgenic mouse model (APPswe/PS1dE9) of Alzheimer's disease.

Xiong H, Callaghan D, Wodzinska J, Xu J, Premyslova M, Liu QY, Connelly J, Zhang W.

Neurosci Bull. 2011 Aug;27(4):221-32. doi: 10.1007/s12264-011-1015-7.

PMID:
21788993
13.

Lack of ABCA1 considerably decreases brain ApoE level and increases amyloid deposition in APP23 mice.

Koldamova R, Staufenbiel M, Lefterov I.

J Biol Chem. 2005 Dec 30;280(52):43224-35. Epub 2005 Oct 5.

14.

Partial reduction of BACE1 has dramatic effects on Alzheimer plaque and synaptic pathology in APP Transgenic Mice.

McConlogue L, Buttini M, Anderson JP, Brigham EF, Chen KS, Freedman SB, Games D, Johnson-Wood K, Lee M, Zeller M, Liu W, Motter R, Sinha S.

J Biol Chem. 2007 Sep 7;282(36):26326-34. Epub 2007 Jul 6.

15.

Levels and alternative splicing of amyloid beta protein precursor (APP) transcripts in brains of APP transgenic mice and humans with Alzheimer's disease.

Rockenstein EM, McConlogue L, Tan H, Power M, Masliah E, Mucke L.

J Biol Chem. 1995 Nov 24;270(47):28257-67.

16.
17.

Voluntary running and environmental enrichment restores impaired hippocampal neurogenesis in a triple transgenic mouse model of Alzheimer's disease.

Rodríguez JJ, Noristani HN, Olabarria M, Fletcher J, Somerville TD, Yeh CY, Verkhratsky A.

Curr Alzheimer Res. 2011 Nov;8(7):707-17.

PMID:
21453244
18.

Alterations in brain cholesterol metabolism in the APPSLxPS1mut mouse, a model for Alzheimer's disease.

Vanmierlo T, Bloks VW, van Vark-van der Zee LC, Rutten K, Kerksiek A, Friedrichs S, Sijbrands E, Steinbusch HW, Kuipers F, Lütjohann D, Mulder M.

J Alzheimers Dis. 2010;19(1):117-27. doi: 10.3233/JAD-2010-1209.

PMID:
20061631
19.

Neuropep-1 ameliorates learning and memory deficits in an Alzheimer's disease mouse model, increases brain-derived neurotrophic factor expression in the brain, and causes reduction of amyloid beta plaques.

Shin MK, Kim HG, Baek SH, Jung WR, Park DI, Park JS, Jo DG, Kim KL.

Neurobiol Aging. 2014 May;35(5):990-1001. doi: 10.1016/j.neurobiolaging.2013.10.091. Epub 2013 Oct 29.

PMID:
24268884
20.

Magnetic resonance imaging of Alzheimer's pathology in the brains of living transgenic mice: a new tool in Alzheimer's disease research.

Jack CR Jr, Marjanska M, Wengenack TM, Reyes DA, Curran GL, Lin J, Preboske GM, Poduslo JF, Garwood M.

Neuroscientist. 2007 Feb;13(1):38-48. Review.

PMID:
17229974

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