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Items: 1 to 20 of 120

1.

ALK1-Fc inhibits multiple mediators of angiogenesis and suppresses tumor growth.

Mitchell D, Pobre EG, Mulivor AW, Grinberg AV, Castonguay R, Monnell TE, Solban N, Ucran JA, Pearsall RS, Underwood KW, Seehra J, Kumar R.

Mol Cancer Ther. 2010 Feb;9(2):379-88. doi: 10.1158/1535-7163.MCT-09-0650. Epub 2010 Feb 2.

2.

Genetic and pharmacological targeting of activin receptor-like kinase 1 impairs tumor growth and angiogenesis.

Cunha SI, Pardali E, Thorikay M, Anderberg C, Hawinkels L, Goumans MJ, Seehra J, Heldin CH, ten Dijke P, Pietras K.

J Exp Med. 2010 Jan 18;207(1):85-100. doi: 10.1084/jem.20091309. Epub 2010 Jan 11.

3.

Activin Receptor-like Kinase 1 Ligand Trap Reduces Microvascular Density and Improves Chemotherapy Efficiency to Various Solid Tumors.

Hawinkels LJ, de Vinuesa AG, Paauwe M, Kruithof-de Julio M, Wiercinska E, Pardali E, Mezzanotte L, Keereweer S, Braumuller TM, Heijkants RC, Jonkers J, Löwik CW, Goumans MJ, ten Hagen TL, ten Dijke P.

Clin Cancer Res. 2016 Jan 1;22(1):96-106. doi: 10.1158/1078-0432.CCR-15-0743. Epub 2015 Sep 15.

4.

Soluble endoglin specifically binds bone morphogenetic proteins 9 and 10 via its orphan domain, inhibits blood vessel formation, and suppresses tumor growth.

Castonguay R, Werner ED, Matthews RG, Presman E, Mulivor AW, Solban N, Sako D, Pearsall RS, Underwood KW, Seehra J, Kumar R, Grinberg AV.

J Biol Chem. 2011 Aug 26;286(34):30034-46. doi: 10.1074/jbc.M111.260133. Epub 2011 Jul 7.

5.

Regulation of the ALK1 ligands, BMP9 and BMP10.

Li W, Salmon RM, Jiang H, Morrell NW.

Biochem Soc Trans. 2016 Aug 15;44(4):1135-41. doi: 10.1042/BST20160083. Review.

PMID:
27528761
6.

Bone morphogenetic protein-9 is a circulating vascular quiescence factor.

David L, Mallet C, Keramidas M, Lamandé N, Gasc JM, Dupuis-Girod S, Plauchu H, Feige JJ, Bailly S.

Circ Res. 2008 Apr 25;102(8):914-22. doi: 10.1161/CIRCRESAHA.107.165530. Epub 2008 Feb 28.

7.

Identification of BMP9 and BMP10 as functional activators of the orphan activin receptor-like kinase 1 (ALK1) in endothelial cells.

David L, Mallet C, Mazerbourg S, Feige JJ, Bailly S.

Blood. 2007 Mar 1;109(5):1953-61. Epub 2006 Oct 26.

8.

Anti-human activin receptor-like kinase 1 (ALK1) antibody attenuates bone morphogenetic protein 9 (BMP9)-induced ALK1 signaling and interferes with endothelial cell sprouting.

van Meeteren LA, Thorikay M, Bergqvist S, Pardali E, Stampino CG, Hu-Lowe D, Goumans MJ, ten Dijke P.

J Biol Chem. 2012 May 25;287(22):18551-61. doi: 10.1074/jbc.M111.338103. Epub 2012 Apr 5.

9.

BMP9 induces EphrinB2 expression in endothelial cells through an Alk1-BMPRII/ActRII-ID1/ID3-dependent pathway: implications for hereditary hemorrhagic telangiectasia type II.

Kim JH, Peacock MR, George SC, Hughes CC.

Angiogenesis. 2012 Sep;15(3):497-509. doi: 10.1007/s10456-012-9277-x. Epub 2012 May 24.

10.

Bone morphogenetic protein (BMP) and activin type II receptors balance BMP9 signals mediated by activin receptor-like kinase-1 in human pulmonary artery endothelial cells.

Upton PD, Davies RJ, Trembath RC, Morrell NW.

J Biol Chem. 2009 Jun 5;284(23):15794-804. doi: 10.1074/jbc.M109.002881. Epub 2009 Apr 14.

11.

BMP-9 signals via ALK1 and inhibits bFGF-induced endothelial cell proliferation and VEGF-stimulated angiogenesis.

Scharpfenecker M, van Dinther M, Liu Z, van Bezooijen RL, Zhao Q, Pukac L, Löwik CW, ten Dijke P.

J Cell Sci. 2007 Mar 15;120(Pt 6):964-72. Epub 2007 Feb 20.

12.

Tmem100, an ALK1 receptor signaling-dependent gene essential for arterial endothelium differentiation and vascular morphogenesis.

Somekawa S, Imagawa K, Hayashi H, Sakabe M, Ioka T, Sato GE, Inada K, Iwamoto T, Mori T, Uemura S, Nakagawa O, Saito Y.

Proc Natl Acad Sci U S A. 2012 Jul 24;109(30):12064-9. doi: 10.1073/pnas.1207210109. Epub 2012 Jul 10.

13.

Specificity and structure of a high affinity activin receptor-like kinase 1 (ALK1) signaling complex.

Townson SA, Martinez-Hackert E, Greppi C, Lowden P, Sako D, Liu J, Ucran JA, Liharska K, Underwood KW, Seehra J, Kumar R, Grinberg AV.

J Biol Chem. 2012 Aug 10;287(33):27313-25. doi: 10.1074/jbc.M112.377960. Epub 2012 Jun 20.

14.

Regulation of bone morphogenetic protein-4 by matrix GLA protein in vascular endothelial cells involves activin-like kinase receptor 1.

Yao Y, Zebboudj AF, Shao E, Perez M, Boström K.

J Biol Chem. 2006 Nov 10;281(45):33921-30. Epub 2006 Sep 1.

15.

Targeting tumour vasculature by inhibiting activin receptor-like kinase (ALK)1 function.

de Vinuesa AG, Bocci M, Pietras K, Ten Dijke P.

Biochem Soc Trans. 2016 Aug 15;44(4):1142-9. doi: 10.1042/BST20160093. Review.

PMID:
27528762
16.

BMP9 Induces Cord Blood-Derived Endothelial Progenitor Cell Differentiation and Ischemic Neovascularization via ALK1.

Kim J, Kim M, Jeong Y, Lee WB, Park H, Kwon JY, Kim YM, Hwang D, Kwon YG.

Arterioscler Thromb Vasc Biol. 2015 Sep;35(9):2020-31. doi: 10.1161/ATVBAHA.115.306142. Epub 2015 Jul 30.

17.

Activin receptor-like kinase 1 as a target for anti-angiogenesis therapy.

Hawinkels LJ, Garcia de Vinuesa A, Ten Dijke P.

Expert Opin Investig Drugs. 2013 Nov;22(11):1371-83. doi: 10.1517/13543784.2013.837884. Epub 2013 Sep 21. Review. Erratum in: Expert Opin Investig Drugs. 2013 Dec;22(12):1695.

PMID:
24053899
18.

Activin receptor-like kinase 1 modulates transforming growth factor-beta 1 signaling in the regulation of angiogenesis.

Oh SP, Seki T, Goss KA, Imamura T, Yi Y, Donahoe PK, Li L, Miyazono K, ten Dijke P, Kim S, Li E.

Proc Natl Acad Sci U S A. 2000 Mar 14;97(6):2626-31.

19.

BMP9 and BMP10 are critical for postnatal retinal vascular remodeling.

Ricard N, Ciais D, Levet S, Subileau M, Mallet C, Zimmers TA, Lee SJ, Bidart M, Feige JJ, Bailly S.

Blood. 2012 Jun 21;119(25):6162-71. doi: 10.1182/blood-2012-01-407593. Epub 2012 May 7.

20.

Vascular injury triggers Krüppel-like factor 6 mobilization and cooperation with specificity protein 1 to promote endothelial activation through upregulation of the activin receptor-like kinase 1 gene.

Garrido-Martín EM, Blanco FJ, Roquè M, Novensà L, Tarocchi M, Lang UE, Suzuki T, Friedman SL, Botella LM, Bernabéu C.

Circ Res. 2013 Jan 4;112(1):113-27. doi: 10.1161/CIRCRESAHA.112.275586. Epub 2012 Oct 9.

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