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Items: 1 to 20 of 141


Human tyrosine hydroxylase natural genetic variation: delineation of functional transcriptional control motifs disrupted in the proximal promoter.

Zhang K, Zhang L, Rao F, Brar B, Rodriguez-Flores JL, Taupenot L, O'Connor DT.

Circ Cardiovasc Genet. 2010 Apr;3(2):187-98. doi: 10.1161/CIRCGENETICS.109.904813. Epub 2010 Feb 2.


Tyrosine hydroxylase, the rate-limiting enzyme in catecholamine biosynthesis: discovery of common human genetic variants governing transcription, autonomic activity, and blood pressure in vivo.

Rao F, Zhang L, Wessel J, Zhang K, Wen G, Kennedy BP, Rana BK, Das M, Rodriguez-Flores JL, Smith DW, Cadman PE, Salem RM, Mahata SK, Schork NJ, Taupenot L, Ziegler MG, O'Connor DT.

Circulation. 2007 Aug 28;116(9):993-1006. Epub 2007 Aug 13.


Conserved regulatory motifs at phenylethanolamine N-methyltransferase (PNMT) are disrupted by common functional genetic variation: an integrated computational/experimental approach.

Rodríguez-Flores JL, Zhang K, Kang SW, Wen G, Ghosh S, Friese RS, Mahata SK, Subramaniam S, Hamilton BA, O'Connor DT.

Mamm Genome. 2010 Apr;21(3-4):195-204. doi: 10.1007/s00335-010-9253-y. Epub 2010 Mar 5.


Human tyrosine hydroxylase natural allelic variation: influence on autonomic function and hypertension.

Rao F, Zhang K, Zhang L, Rana BK, Wessel J, Fung MM, Rodriguez-Flores JL, Taupenot L, Ziegler MG, O'Connor DT.

Cell Mol Neurobiol. 2010 Nov;30(8):1391-4. doi: 10.1007/s10571-010-9535-7. Epub 2010 Jun 23.


Adrenergic polymorphism and the human stress response.

Rao F, Zhang L, Wessel J, Zhang K, Wen G, Kennedy BP, Rana BK, Das M, Rodriguez-Flores JL, Smith DW, Cadman PE, Salem RM, Mahata SK, Schork NJ, Taupenot L, Ziegler MG, O'Connor DT.

Ann N Y Acad Sci. 2008 Dec;1148:282-96. doi: 10.1196/annals.1410.085.


Heredity and cardiometabolic risk: naturally occurring polymorphisms in the human neuropeptide Y(2) receptor promoter disrupt multiple transcriptional response motifs.

Wei Z, Zhang K, Wen G, Balasubramanian K, Shih PA, Rao F, Friese RS, Miramontes-Gonzalez JP, Schmid-Schoenbein GW, Kim HS, Mahata SK, O'Connor DT.

J Hypertens. 2013 Jan;31(1):123-33. doi: 10.1097/HJH.0b013e32835b053d.


Interactions between Egr1 and AP1 factors in regulation of tyrosine hydroxylase transcription.

Nakashima A, Ota A, Sabban EL.

Brain Res Mol Brain Res. 2003 Apr 10;112(1-2):61-9.


Functional polymorphism (C-824T) of the tyrosine hydroxylase gene affects IQ in schizophrenia.

Horiguchi M, Ohi K, Hashimoto R, Hao Q, Yasuda Y, Yamamori H, Fujimoto M, Umeda-Yano S, Takeda M, Ichinose H.

Psychiatry Clin Neurosci. 2014 Jun;68(6):456-62. doi: 10.1111/pcn.12157. Epub 2014 Feb 26.


Functional allelic heterogeneity and pleiotropy of a repeat polymorphism in tyrosine hydroxylase: prediction of catecholamines and response to stress in twins.

Zhang L, Rao F, Wessel J, Kennedy BP, Rana BK, Taupenot L, Lillie EO, Cockburn M, Schork NJ, Ziegler MG, O'Connor DT.

Physiol Genomics. 2004 Nov 17;19(3):277-91. Epub 2004 Sep 14.


Transcriptional regulation mechanisms of hypoxia-induced neuroglobin gene expression.

Liu N, Yu Z, Xiang S, Zhao S, Tjärnlund-Wolf A, Xing C, Zhang J, Wang X.

Biochem J. 2012 Apr 1;443(1):153-64. doi: 10.1042/BJ20111856.


Common functional genetic variants in catecholamine storage vesicle protein promoter motifs interact to trigger systemic hypertension.

Zhang K, Rao F, Wang L, Rana BK, Ghosh S, Mahata M, Salem RM, Rodriguez-Flores JL, Fung MM, Waalen J, Tayo B, Taupenot L, Mahata SK, O'Connor DT.

J Am Coll Cardiol. 2010 Apr 6;55(14):1463-75. doi: 10.1016/j.jacc.2009.11.064.


Human dopamine β-hydroxylase promoter variant alters transcription in chromaffin cells, enzyme secretion, and blood pressure.

Chen Y, Zhang K, Wen G, Rao F, Sanchez AP, Wang L, Rodriguez-Flores JL, Mahata M, Mahata SK, Waalen J, Ziegler MG, Hamilton BA, O'Connor DT.

Am J Hypertens. 2011 Jan;24(1):24-32. doi: 10.1038/ajh.2010.186. Epub 2010 Sep 2.


G-Quadruplex-Enabling Sequence within the Human Tyrosine Hydroxylase Promoter Differentially Regulates Transcription.

Farhath MM, Thompson M, Ray S, Sewell A, Balci H, Basu S.

Biochemistry. 2015 Sep 15;54(36):5533-45. doi: 10.1021/acs.biochem.5b00209. Epub 2015 Aug 28.


Neuropeptide Y (NPY): genetic variation in the human promoter alters glucocorticoid signaling, yielding increased NPY secretion and stress responses.

Zhang K, Rao F, Miramontes-Gonzalez JP, Hightower CM, Vaught B, Chen Y, Greenwood TA, Schork AJ, Wang L, Mahata M, Stridsberg M, Khandrika S, Biswas N, Fung MM, Waalen J, Middelberg RP, Heath AC, Montgomery GW, Martin NG, Whitfield JB, Baker DG, Schork NJ, Nievergelt CM, O'Connor DT.

J Am Coll Cardiol. 2012 Oct 23;60(17):1678-89. doi: 10.1016/j.jacc.2012.06.042. Epub 2012 Sep 26. Erratum in: J Am Coll Cardiol. 2012 Nov 20;60(21):2261.


Regulation of tyrosine hydroxylase gene transcription by Sry.

Milsted A, Serova L, Sabban EL, Dunphy G, Turner ME, Ely DL.

Neurosci Lett. 2004 Oct 21;369(3):203-7.


Genes and environment: novel, functional polymorphism in the human cathepsin L (CTSL1) promoter disrupts a xenobiotic response element (XRE) to alter transcription and blood pressure.

Mbewe-Campbell N, Wei Z, Zhang K, Friese RS, Mahata M, Schork AJ, Rao F, Chiron S, Biswas N, Kim HS, Mahata SK, Waalen J, Nievergelt CM, Hook VY, O'Connor DT.

J Hypertens. 2012 Oct;30(10):1961-9.


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