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Items: 1 to 20 of 122


Engineering novel complement activity into a pulmonary surfactant protein.

Venkatraman Girija U, Furze C, Toth J, Schwaeble WJ, Mitchell DA, Keeble AH, Wallis R.

J Biol Chem. 2010 Apr 2;285(14):10546-52. doi: 10.1074/jbc.M109.097493. Epub 2010 Jan 29.


Mannose-binding lectin (MBL)-associated serine protease (MASP)-1 contributes to activation of the lectin complement pathway.

Takahashi M, Iwaki D, Kanno K, Ishida Y, Xiong J, Matsushita M, Endo Y, Miura S, Ishii N, Sugamura K, Fujita T.

J Immunol. 2008 May 1;180(9):6132-8.


Decoupling of carbohydrate binding and MASP-2 autoactivation in variant mannose-binding lectins associated with immunodeficiency.

Wallis R, Lynch NJ, Roscher S, Reid KB, Schwaeble WJ.

J Immunol. 2005 Nov 15;175(10):6846-51.


Dissociation and re-association studies on the interaction domains of mannan-binding lectin (MBL)-associated serine proteases, MASP-1 and MASP-2, provide evidence for heterodimer formation.

Paréj K, Hermann A, Donáth N, Závodszky P, Gál P, Dobó J.

Mol Immunol. 2014 May;59(1):1-9. doi: 10.1016/j.molimm.2013.12.003. Epub 2014 Jan 11.


Two mechanisms for mannose-binding protein modulation of the activity of its associated serine proteases.

Chen CB, Wallis R.

J Biol Chem. 2004 Jun 18;279(25):26058-65. Epub 2004 Apr 1.


The structure of MBL-associated serine protease-2 reveals that identical substrate specificities of C1s and MASP-2 are realized through different sets of enzyme-substrate interactions.

Harmat V, Gál P, Kardos J, Szilágyi K, Ambrus G, Végh B, Náray-Szabó G, Závodszky P.

J Mol Biol. 2004 Oct 1;342(5):1533-46.


Interaction of C1q and mannan-binding lectin (MBL) with C1r, C1s, MBL-associated serine proteases 1 and 2, and the MBL-associated protein MAp19.

Thiel S, Petersen SV, Vorup-Jensen T, Matsushita M, Fujita T, Stover CM, Schwaeble WJ, Jensenius JC.

J Immunol. 2000 Jul 15;165(2):878-87.


Essential role of mannose-binding lectin-associated serine protease-1 in activation of the complement factor D.

Takahashi M, Ishida Y, Iwaki D, Kanno K, Suzuki T, Endo Y, Homma Y, Fujita T.

J Exp Med. 2010 Jan 18;207(1):29-37. doi: 10.1084/jem.20090633. Epub 2009 Dec 28.


Characterization of the interaction between L-ficolin/p35 and mannan-binding lectin-associated serine proteases-1 and -2.

Cseh S, Vera L, Matsushita M, Fujita T, Arlaud GJ, Thielens NM.

J Immunol. 2002 Nov 15;169(10):5735-43.


Assembly of C1 and the MBL- and ficolin-MASP complexes: structural insights.

Gaboriaud C, Teillet F, Gregory LA, Thielens NM, Arlaud GJ.

Immunobiology. 2007;212(4-5):279-88. Epub 2006 Dec 20. Review.


A novel mannose-binding lectin/ficolin-associated protein is highly expressed in heart and skeletal muscle tissues and inhibits complement activation.

Skjoedt MO, Hummelshoj T, Palarasah Y, Honore C, Koch C, Skjodt K, Garred P.

J Biol Chem. 2010 Mar 12;285(11):8234-43. doi: 10.1074/jbc.M109.065805. Epub 2010 Jan 6.


Co-complexes of MASP-1 and MASP-2 associated with the soluble pattern-recognition molecules drive lectin pathway activation in a manner inhibitable by MAp44.

Degn SE, Jensen L, Olszowski T, Jensenius JC, Thiel S.

J Immunol. 2013 Aug 1;191(3):1334-45. doi: 10.4049/jimmunol.1300780. Epub 2013 Jun 19.


Deciphering complement receptor type 1 interactions with recognition proteins of the lectin complement pathway.

Jacquet M, Lacroix M, Ancelet S, Gout E, Gaboriaud C, Thielens NM, Rossi V.

J Immunol. 2013 Apr 1;190(7):3721-31. doi: 10.4049/jimmunol.1202451. Epub 2013 Mar 4.


Structure and function of complement activating enzyme complexes: C1 and MBL-MASPs.

Gál P, Ambrus G.

Curr Protein Pept Sci. 2001 Mar;2(1):43-59. Review.


Scabies mite inactive serine proteases are potent inhibitors of the human complement lectin pathway.

Reynolds SL, Pike RN, Mika A, Blom AM, Hofmann A, Wijeyewickrema LC, Kemp D, Fischer K.

PLoS Negl Trop Dis. 2014 May 22;8(5):e2872. doi: 10.1371/journal.pntd.0002872. eCollection 2014 May.


Cloning and characterization of mannose-binding lectin from lamprey (Agnathans).

Takahashi M, Iwaki D, Matsushita A, Nakata M, Matsushita M, Endo Y, Fujita T.

J Immunol. 2006 Apr 15;176(8):4861-8.


MAp44, a human protein associated with pattern recognition molecules of the complement system and regulating the lectin pathway of complement activation.

Degn SE, Hansen AG, Steffensen R, Jacobsen C, Jensenius JC, Thiel S.

J Immunol. 2009 Dec 1;183(11):7371-8. doi: 10.4049/jimmunol.0902388. Epub 2009 Nov 16.


Recombinant expression of the autocatalytic complement protease MASP-1 is crucially dependent on co-expression with its inhibitor, C1 inhibitor.

Degn SE, Thiel S, Jensenius JC.

Protein Expr Purif. 2013 Apr;88(2):173-82. doi: 10.1016/j.pep.2013.01.002. Epub 2013 Jan 11.


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